| Summary: | To discover novel, potent anti-inflammatory diterpenoids, a series of hybrids of 7-oxodehydroabietic acid bearing a 1,2,3-triazole moiety was designed and synthesized. The target compounds were characterized by means of <sup>1</sup>H NMR, <sup>13</sup>C NMR, and ESI-HRMS. All the compounds were evaluated for their anti-inflammatory activity towards BV2 cell lines using L-NMMA (IC<sub>50</sub> = 42.36 ± 2.47 µM) as a positive control. Most showed good anti-inflammatory activities, especially compounds <b>10</b> (IC<sub>50</sub> = 8.40 ± 0.98 µM), <b>15</b> (IC<sub>50</sub> = 10.74 ± 2.67 µM), <b>16</b> (IC<sub>50</sub> = 10.96 ± 1.85 µM), and <b>17</b> (IC<sub>50</sub> = 9.76 ± 1.27 µM), which exhibited potent anti-inflammatory effects on BV2 cell lines.
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