CD226 maintains regulatory T cell phenotype stability and metabolism by the mTOR/Myc pathway under inflammatory conditions

Summary: Regulatory T (Treg) cells exhibit immunosuppressive phenotypes and particular metabolic patterns with certain degrees of plasticity. Previous studies of the effects of the co-stimulatory molecule CD226 on Treg cells are controversial. Here, we show that CD226 primarily maintains the Treg ce...

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Bibliographic Details

Published in:	Cell Reports
Main Authors:	Jingchang Ma, Wei Hu, Yitian Liu, Chujun Duan, Dongliang Zhang, Yuling Wang, Kun Cheng, Lu Yang, Shuwen Wu, Boquan Jin, Yuan Zhang, Ran Zhuang
Format:	Article
Language:	English
Published:	Elsevier 2023-10-01
Subjects:	CP: Immunology
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124723013189