KIBRA repairs synaptic plasticity and promotes resilience to tauopathy-related memory loss

Synaptic plasticity is obstructed by pathogenic tau in the brain, representing a key mechanism that underlies memory loss in Alzheimer’s disease (AD) and related tauopathies. Here, we found that reduced levels of the memory-associated protein KIdney/BRAin (KIBRA) in the brain and increased KIBRA pro...

Full description

Bibliographic Details
Published in:	The Journal of Clinical Investigation
Main Authors:	Grant Kauwe, Kristeen A. Pareja-Navarro, Lei Yao, Jackson H. Chen, Ivy Wong, Rowan Saloner, Helen Cifuentes, Alissa L. Nana, Samah Shah, Yaqiao Li, David Le, Salvatore Spina, Lea T. Grinberg, William W. Seeley, Joel H. Kramer, Todd C. Sacktor, Birgit Schilling, Li Gan, Kaitlin B. Casaletto, Tara E. Tracy
Format:	Article
Language:	English
Published:	American Society for Clinical Investigation 2024-02-01
Subjects:	Neuroscience
Online Access:	https://doi.org/10.1172/JCI169064

Similar Items

KIBRA regulates activity-induced AMPA receptor expression and synaptic plasticity in an age-dependent manner
by: Matthew L. Mendoza, et al.
Published: (2022-12-01)

Kibra Modulates Learning and Memory via Binding to Dendrin
by: Zeyang Ji, et al.
Published: (2019-02-01)

The role of the KIBRA and APOE genes in developing spatial abilities in humans
by: A. V. Kazantseva, et al.
Published: (2022-01-01)

KIBRA upregulation increases susceptibility to podocyte injury and glomerular disease progression
by: Kristin Meliambro, et al.
Published: (2023-04-01)

Tauopathy strains differentially replicate in vitro in the presence of mutant tau monomer
by: Christine K. Brown, et al.
Published: (2025-10-01)

Interrogating the plasma proteome of repetitive head impact exposure and chronic traumatic encephalopathy
by: Rowan Saloner, et al.
Published: (2025-06-01)

KIBRA Gene Polymorphism Has No Association With Verbal or Visual Episodic Memory Performance
by: James C Vickers, et al.
Published: (2014-10-01)

Spatiotemporal characteristics of neurophysiological changes in patients with four‐repeat tauopathies
by: Niyatee Samudra, et al.
Published: (2024-02-01)

Low KIBRA Expression Is Associated with Poor Prognosis in Patients with Triple-Negative Breast Cancer
by: So-Woon Kim, et al.
Published: (2021-08-01)

Experience alters hippocampal and cortical network communication via a KIBRA-dependent mechanism
by: Lilyana D. Quigley, et al.
Published: (2023-06-01)

Multimodal lifestyle engagement patterns support cognitive stability beyond neuropathological burden
by: Emily W. Paolillo, et al.
Published: (2023-12-01)

Hydromethylthionine rescues synaptic SNARE proteins in a mouse model of tauopathies: Interference by cholinesterase inhibitors
by: Karima Schwab, et al.
Published: (2024-06-01)

Negative feedback couples Hippo pathway activation with Kibra degradation independent of Yorkie-mediated transcription
by: Sherzod A Tokamov, et al.
Published: (2021-02-01)

Association of peripheral blood leukocyte KIBRA methylation with gastric cancer risk: a case–control study
by: Yan Zhang, et al.
Published: (2018-06-01)

Neuronal and glial vulnerability of the suprachiasmatic nucleus in tauopathies: evidence from human studies and animal models
by: Gowoon Son, et al.
Published: (2024-01-01)

Anti-acetylated-tau immunotherapy is neuroprotective in tauopathy and brain injury
by: Celeste Parra Bravo, et al.
Published: (2024-06-01)

CRISPR-based epigenetic editing of Gad1 improves synaptic inhibition and cognitive behavior in a Tauopathy mouse model
by: Lei Wan, et al.
Published: (2025-03-01)

KIBRA promoter methylation and association with clinical manifestation of renal cancer: A study in a tertiary institute in eastern India
by: Avisek Dutta, et al.
Published: (2023-09-01)

Exploring the significance of caspase-cleaved tau in tauopathies and as a complementary pathology to phospho-tau in Alzheimer’s disease: implications for biomarker development and therapeutic targeting
by: Liara Rizzi, et al.
Published: (2024-02-01)

Hemimegalencephaly: A Foetal Tauopathy
by: J Gordon Millichap
Published: (2013-02-01)

Heparan Sulfate Proteoglycans in Tauopathy
by: Yanan Zhu, et al.
Published: (2022-11-01)

Publisher Correction: Exploring the significance of caspase-cleaved tau in tauopathies and as a complementary pathology to phospho-tau in Alzheimer’s disease: implications for biomarker development and therapeutic targeting
by: Liara Rizzi, et al.
Published: (2024-04-01)

Kibra knockdown inhibits the aberrant Hippo pathway, suppresses renal cyst formation and ameliorates renal fibrosis in nphp1KO mice
by: Yichen Yang, et al.
Published: (2025-03-01)

DNA Methylation in Genetic and Sporadic Forms of Neurodegeneration: Lessons from Alzheimer’s, Related Tauopathies and Genetic Tauopathies
by: Geraldine Zimmer-Bensch, et al.
Published: (2021-11-01)

Electrophysiology-based screening identifies neuronal HtrA serine peptidase 2 (HTRA2) as a synaptic plasticity regulator participating in tauopathy
by: Naizhen Zheng, et al.
Published: (2025-01-01)

Tauopathy and neurodegeneration: A role for stress
by: Jorge A. Sierra-Fonseca, et al.
Published: (2018-11-01)

Barcodes distinguishing morphology of neuronal tauopathy
by: David Beers, et al.
Published: (2023-10-01)

The therapeutic landscape of tauopathies: challenges and prospects
by: Jeffrey L. Cummings, et al.
Published: (2023-10-01)

A potential therapeutic approach for tauopathies
by: Pradeep Reddy Cingaram
Published: (2022-12-01)

Cellular and pathological heterogeneity of primary tauopathies
by: Dah-eun Chloe Chung, et al.
Published: (2021-08-01)

Astroglial toxicity promotes synaptic degeneration in the thalamocortical circuit in frontotemporal dementia with GRN mutations
by: Elise Marsan, et al.
Published: (2023-03-01)

A Comprehensive Resource for Induced Pluripotent Stem Cells from Patients with Primary Tauopathies
by: Celeste M. Karch, et al.
Published: (2019-11-01)

Emerging roles for innate and adaptive immunity in tauopathies
by: Alexis M. Johnson, et al.
Published: (2025-09-01)

Tauopathy and cognitive impairment in experimental diabetes mellitus
by: Mariia V. Matveeva, et al.
Published: (2017-08-01)

The Functional Role of microRNAs in the Pathogenesis of Tauopathy
by: Domenico Praticò
Published: (2020-10-01)

Oxidative Stress in Tauopathies: From Cause to Therapy
by: Fernando Bartolome, et al.
Published: (2022-07-01)

Mathematical topology and geometry-based classification of tauopathies
by: Masumi Sugiyama, et al.
Published: (2024-03-01)

Involvement of Oligodendrocytes in Tau Seeding and Spreading in Tauopathies
by: Isidro Ferrer, et al.
Published: (2019-05-01)

Alzheimer's Disease and tauopathy studies in flies and worms
by: Jill Wentzell, et al.
Published: (2010-10-01)

Antisense Oligodeoxynucleotide Perfusion Blocks Gene Expression of Synaptic Plasticity-related Proteins without Inducing Compensation in Hippocampal Slices
by: Panayiotis Tsokas, et al.
Published: (2019-10-01)