Markers of Oxidative Stress in Patients with Acne: A Literature Review

• Published in: Life
• Main Authors: Gabriela Loredana Popa, Cristina Iulia Mitran, Madalina Irina Mitran, Mircea Tampa, Clara Matei, Mircea Ioan Popa, Simona Roxana Georgescu
• Format: Article
• Language: English
• Published: MDPI AG 2023-06-01
• Subjects: acne vulgaris; oxidative stress; markers; isotretinoin
• Online Access: https://www.mdpi.com/2075-1729/13/7/1433

Acne vulgaris is a chronic inflammatory skin disease of the pilosebaceous unit. Its pathogenesis is multifactorial and involves the overlap between four main processes: alteration of the keratinization, increased sebum production, colonization with <i>Cutibacterium acnes</i>, and inflammation. The role of oxidative stress (OS) has been intensively studied in inflammatory skin conditions such as psoriasis, vitiligo, or atopic dermatitis. However, the involvement of OS in the pathogenesis of acne is less known. The evidence accumulated over the last decade suggests that in the case of acne patients, there is an imbalance between oxidants and antioxidants. In this review, we analyzed studies that evaluated markers of OS in patients with acne, published in the last ten years, with the aim of providing new insights into the pathogenesis of acne.