Design, synthesis and antitumor activity of 3,4,5-Trisubstituted Isoxazoles

In this study, 56 isoxazole derivatives were synthesized and their antitumor activity against 9 cancer cells, such as BXPC-3, MiaPaCa-2, PANC-1, MCF-7, HCT-116, HepG2, NCI-H460, A549 and B16 was detected. The results of pharmacological experiments indicated that most compounds exhibit good cytotoxic...

Full description

Bibliographic Details
Published in:	European Journal of Medicinal Chemistry Reports
Main Authors:	Kanghui Duan, Fuxing Tan, Hongming Xie, Haiwang Liu, Yingjun Zhang, Huanfeng Jiang, Wanqing Wu
Format:	Article
Language:	English
Published:	Elsevier 2024-12-01
Subjects:	Isoxazole HCT-116 5-Fluorouracil Anti-tumor
Online Access:	http://www.sciencedirect.com/science/article/pii/S277241742400075X

Similar Items

Synthesis of Fused Isoxazoles: A Comprehensive Review
by: Niveditha N. Mallik, et al.
Published: (2024-01-01)

Relationship between anticancer sensitivities and cellular respiration properties in 5‐fluorouracil‐resistant HCT116 human colorectal cancer cells
by: Chinatsu Kurasaka, et al.
Published: (2023-06-01)

Andrographolide enhanced 5-fluorouracil-induced antitumor effect in colorectal cancer via inhibition of c-MET pathway
by: Su M, et al.
Published: (2017-11-01)

Design and Synthesis of C-19 Isosteviol Derivatives as Potent and Highly Selective Antiproliferative Agents
by: Tian Luan, et al.
Published: (2018-12-01)

Synthesis and Structure of Unsymmetrical Anthracenyl-Isoxazole Antitumor Agents Via the Diastereoselective Bromination of 3-(9′-Anthryl)-Isoxazole Esters
by: Michael J. Campbell, et al.
Published: (2024-03-01)

The design, synthesis and antiplasmodial evaluation of novel sulfoximine-isoxazole hybrids as potential antimalarial agents
by: Jackie L. Mabasa, et al.
Published: (2024-04-01)

Cytotoxic Effects of Lactobacilli Isolated from Azerbaijan Traditional Cheeses on Colorectal Tumor Cells HCT 116 and Identification of Paramount Strains
by: Mitra Rabiei, et al.
Published: (2018-07-01)

Direct ring fluorination of 3-substituted 5-(1,3-dioxane) acetal isoxazoles: application to the formal synthesis of a bioactive fluorinated isoxazole
by: Bacheley, Lucas, et al.
Published: (2024-02-01)

New derivatives of sulfonylhydrazone as potential antitumor agents: Design, synthesis and cheminformatics evaluation
by: Sabbah Dima A., et al.
Published: (2021-12-01)

Cabazitaxel suppresses colorectal cancer cell growth via enhancing the p53 antitumor pathway
by: Wen Zhang, et al.
Published: (2021-11-01)

Decreasing the ability of HCT116 cells to escape from therapy induced senescence by increasing the duration of doxorubicin treatment
by: N. A. Persiyantseva, et al.
Published: (2024-04-01)

Micropropagation of Rare <i>Scutellaria havanensis</i> Jacq. and Preliminary Studies on Antioxidant Capacity and Anti-Cancer Potential
by: Lani Irvin, et al.
Published: (2021-09-01)

Cytotoxic Metabolites from the Okinawan Ascidian Diplosoma virens
by: Katsuhiro Ueda, et al.
Published: (2008-03-01)

Syntheses and crystal structures of a nitro–anthracene–isoxazole and its oxidation product
by: Chun Li, et al.
Published: (2022-07-01)

Synthesis and biological evaluation of N-Alkylamide derivatives as anti-tumor agents
by: Kunxiu Jiang, et al.
Published: (2020-12-01)

Synthesis and pharmacological characterization of glucopyranosyl-conjugated benzyl derivatives as novel selective cytotoxic agents against colon cancer
by: Boqiao Fu, et al.
Published: (2021-02-01)

Green synthesis of silver nanoparticles using Magnolia alba leaf extracts and evaluating their antimicrobial, anticancer, antioxidant, and photocatalytic properties
by: Shaveen De Mel, et al.
Published: (2025-07-01)

Electrochemical Synthesis of Isoxazoles and Isoxazolines via Anodic Oxidation of Oximes
by: Silja Hofmann, et al.
Published: (2023-11-01)

Transcriptomic data of bevacizumab-adapted colorectal adenocarcinoma cells HCT-116
by: Sala Cesare, et al.
Published: (2023-06-01)

Trichothecin Inhibits Cancer-Related Features in Colorectal Cancer Development by Targeting STAT3
by: Xin Qi, et al.
Published: (2020-05-01)

Synthesis and Characterization of New Series of 1,3-5-Triazine Hydrazone Derivatives with Promising Antiproliferative Activity
by: Hessa H. Al H. Al Rasheed, et al.
Published: (2020-06-01)

SYNTHESIS OF UNSYMMETRICALLY SUBSTITUTED ISOXAZOLES AS INTERMEDIATES FOR BENT-CORE MESOGENS
by: Gheorghe ROMAN
Published: (2016-06-01)

Design, synthesis and antitumor activity of coumarin, isoxazole, pyrazole, pyridine and pyrimidine compounds: 3β-hydroxypregn-5-ene-20-one derivatives
by: Karam A. El-Sharkawy, et al.
Published: (2023-05-01)

A Convenient Synthesis of Novel Isoxazolidine and Isoxazole Isoquinolinones Fused Hybrids
by: Konstantinos A. Ouzounthanasis, et al.
Published: (2023-12-01)

GB7 acetate, a galbulimima alkaloid from Galbulimima belgraveana, possesses anticancer effects in colorectal cancer cells
by: Ziyin Li, et al.
Published: (2022-04-01)

2′-Fucosyllactose Suppresses Angiogenesis and Alleviates Toxic Effects of 5-Fu in a HCT116 Colon Tumor-Bearing Model
by: Huiying Li, et al.
Published: (2022-10-01)

Study of caspase-6 activity in aggressive HCT116 cells using methotrexate-encapsulated lactoferrin-conjugated solid lipid nanoparticles via in silico and in vitro approaches
by: Sankha Bhattacharya, et al.
Published: (2025-07-01)

Investigation of probiotic properties of Lactiplantibacillus plantarum isolated from hawthorn vinegar
by: Irmak Icen Taskin
Published: (2024-12-01)

The synergistic potential of orange peel extract: A comprehensive investigation into its phenolic composition, antioxidant, antimicrobial, and functional fortification properties in yogurt
by: Asmaa Hussein Zaki, et al.
Published: (2024-06-01)

Detection of Methicillin-Resistant <i>Staphylococcus aureus</i> among Foodborne Pathogenic Strains and Assessment of Their Adhesion Ability and Cytotoxic Effects in HCT-116 Cells
by: Abderrahmen Merghni, et al.
Published: (2023-02-01)

Synthesis, molecular modelling and biological evaluation of new 4-aminothiophene and thienopyrimidine compounds
by: Aisha Hossan, et al.
Published: (2023-12-01)

Synthesis, characterization, molecular docking and pharmacological evaluation of isoxazole derivatives as potent anti-inflammatory agents
by: Sonu, et al.
Published: (2024-11-01)

The Green and Effective Synthesis of Isoxazole-Based Molecules Under Ultrasonic Irradiation Approaches
by: Mei-Tong Chen, et al.
Published: (2025-08-01)

Design, Synthesis, and Antiproliferative Activity of Benzopyran-4-One-Isoxazole Hybrid Compounds
by: Shilpi Gupta, et al.
Published: (2023-05-01)

Synthesis, Anti-proliferative Activity, and Molecular Docking Study of New Series of 1,3-5-Triazine Schiff Base Derivatives
by: Hessa H. Al Rasheed, et al.
Published: (2020-09-01)

Synthesis of a Novel Tetracyclic Isoxazole by Intramolecular Nitrile Oxide Cycloaddition
by: Gavin R. Hoffman, et al.
Published: (2024-02-01)

Lewis acid-promoted direct synthesis of isoxazole derivatives
by: Dengxu Qiu, et al.
Published: (2023-10-01)

Synthesis of the omega-brominated alpha-trifluoroacetylcycloalkanones and their isoxazole derivatives
by: Flores Alex F. C., et al.
Published: (2006-01-01)

Synthesis of new 3,5-substiuted isoxazole derivatives possessing potential anti-aggregative activity
by: O. V. Demina, et al.
Published: (2010-12-01)

Knockout of the sulfide: quinone oxidoreductase SQR reduces growth of HCT116 tumor xenograft
by: Ting Lu, et al.
Published: (2025-06-01)