Improving Islet Engraftment by Gene Therapy
Islet cell transplantation is currently the only feasible long-term treatment option for patients with type 1 diabetes. However, the majority of transplanted islets experience damage and apoptosis during the isolation process, a blood-mediated inflammatory microenvironment in the portal vein upon is...
| Published in: | Journal of Transplantation |
|---|---|
| Main Authors: | Xiaojie Wang, Mark Meloche, C. Bruce Verchere, Dawei Ou, Alice Mui, Garth L. Warnock |
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
|
| Online Access: | http://dx.doi.org/10.1155/2011/594851 |
Similar Items
B7-H4 Pathway in Islet Transplantation and β-Cell Replacement Therapies
by: Xiaojie Wang, et al.
Published: (2011-01-01)
by: Xiaojie Wang, et al.
Published: (2011-01-01)
B7-H4 Treatment of T Cells Inhibits ERK, JNK, p38, and AKT Activation.
by: Xiaojie Wang, et al.
Published: (2012-01-01)
by: Xiaojie Wang, et al.
Published: (2012-01-01)
Advances and Challenges in Islet Transplantation: Islet Procurement Rates and Lessons Learned from Suboptimal Islet Transplantation
by: Annette Plesner, et al.
Published: (2011-01-01)
by: Annette Plesner, et al.
Published: (2011-01-01)
Islet Engraftment and Revascularization in Clinical and Experimental Transplantation
by: Christian Molnár, et al.
Published: (2013-02-01)
by: Christian Molnár, et al.
Published: (2013-02-01)
Generation of Transplantable Beta Cells for Patient-Specific Cell Therapy
by: Xiaojie Wang, et al.
Published: (2012-01-01)
by: Xiaojie Wang, et al.
Published: (2012-01-01)
Bioengineering with Endothelial Progenitor Cells Improves the Vascular Engraftment of Transplanted Human Islets
by: Liza Grapensparr, et al.
Published: (2018-06-01)
by: Liza Grapensparr, et al.
Published: (2018-06-01)
Effect of Cryopreservation on the Survival and Function of Murine Islet Isografts and Allografts
by: Mark S. Cattral, et al.
Published: (1998-07-01)
by: Mark S. Cattral, et al.
Published: (1998-07-01)
Hair Follicle Dermal Sheath Derived Cells Improve Islet Allograft Survival without Systemic Immunosuppression
by: Xiaojie Wang, et al.
Published: (2015-01-01)
by: Xiaojie Wang, et al.
Published: (2015-01-01)
Reversal of Hyperglycemia by Subcutaneous Islet Engraftment Using an Atelocollagen Sponge as a Scaffold
by: Yumeng Wu, et al.
Published: (2024-09-01)
by: Yumeng Wu, et al.
Published: (2024-09-01)
A Gelatin Hydrogel Nonwoven Fabric Enhances Subcutaneous Islet Engraftment in Rats
by: Ryusuke Saito, et al.
Published: (2023-12-01)
by: Ryusuke Saito, et al.
Published: (2023-12-01)
Endothelial Progenitor Cells Enhance Islet Engraftment, Influence β-Cell Function, and Modulate Islet Connexin 36 Expression
by: Daniella Penko, et al.
Published: (2015-01-01)
by: Daniella Penko, et al.
Published: (2015-01-01)
Surface Coating of Pancreatic Islets with Neural Crest Stem Cells Improves Engraftment and Function after Intraportal Transplantation
by: Joey Lau, et al.
Published: (2015-11-01)
by: Joey Lau, et al.
Published: (2015-11-01)
Human Pancreatic Islet Preparations Release HMGB1: (Ir)Relevance for Graft Engraftment
by: Rita Nano, et al.
Published: (2013-11-01)
by: Rita Nano, et al.
Published: (2013-11-01)
Amniotic epithelial cells enhance islet engraftment by suppressing early inflammation in intraportal transplantation
by: Kaoru Okada, et al.
Published: (2026-06-01)
by: Kaoru Okada, et al.
Published: (2026-06-01)
Improving Cell Engraftment in Cardiac Stem Cell Therapy
by: Xiaofei Li, et al.
Published: (2016-01-01)
by: Xiaofei Li, et al.
Published: (2016-01-01)
Strategies for optimizing CITE-seq for human islets and other tissues
by: Sarah J. Colpitts, et al.
Published: (2023-03-01)
by: Sarah J. Colpitts, et al.
Published: (2023-03-01)
Adult muscle-derived stem cells engraft and differentiate into insulin-expressing cells in pancreatic islets of diabetic mice
by: Violeta Mitutsova, et al.
Published: (2017-04-01)
by: Violeta Mitutsova, et al.
Published: (2017-04-01)
Differentiation of mouse embryonic stem cells into endoderm without embryoid body formation.
by: Peter T W Kim, et al.
Published: (2010-01-01)
by: Peter T W Kim, et al.
Published: (2010-01-01)
Amyloid formation reduces protein kinase B phosphorylation in primary islet β-cells which is improved by blocking IL-1β signaling.
by: Yun Zhang, et al.
Published: (2018-01-01)
by: Yun Zhang, et al.
Published: (2018-01-01)
Assessment of protein synthesis rate enables metabolic profiling of resident-immune cells of the islets of Langerhans
by: Lauar de Brito Monteiro, et al.
Published: (2025-09-01)
by: Lauar de Brito Monteiro, et al.
Published: (2025-09-01)
A Recombinant Peptide Device Combined with Adipose Tissue-Derived Stem Cells Enhances Subcutaneous Islet Engraftment
by: Takahiro Mizui, et al.
Published: (2024-03-01)
by: Takahiro Mizui, et al.
Published: (2024-03-01)
Pleckstrin homology-like domain family A, member 3 (PHLDA3) deficiency improves islets engraftment through the suppression of hypoxic damage.
by: Naoaki Sakata, et al.
Published: (2017-01-01)
by: Naoaki Sakata, et al.
Published: (2017-01-01)
Automated Digital Image Analysis of Islet Cell Mass Using Nikon's Inverted Eclipse Ti Microscope and Software to Improve Engraftment may Help to Advance the Therapeutic Efficacy and Accessibility of Islet Transplantation across Centers
by: Valery Gmyr, et al.
Published: (2015-01-01)
by: Valery Gmyr, et al.
Published: (2015-01-01)
A Gelatin Hydrogel Nonwoven Fabric Combined With Adipose Tissue–Derived Stem Cells Enhances Subcutaneous Islet Engraftment
by: Ryusuke Saito, et al.
Published: (2024-05-01)
by: Ryusuke Saito, et al.
Published: (2024-05-01)
Islet Macrophages Shift to a Reparative State following Pancreatic Beta-Cell Death and Are a Major Source of Islet Insulin-like Growth Factor-1
by: Dominika Nackiewicz, et al.
Published: (2020-01-01)
by: Dominika Nackiewicz, et al.
Published: (2020-01-01)
Amyloid formation disrupts the balance between interleukin-1β and interleukin-1 receptor antagonist in human islets
by: Queenie Hui, et al.
Published: (2017-08-01)
by: Queenie Hui, et al.
Published: (2017-08-01)
Xenogenic Engraftment of Human-Induced Pluripotent Stem Cell–Derived Pancreatic Islet Cells in an Immunosuppressive Diabetic Göttingen Mini-Pig Model
by: Midori Yamasaki, et al.
Published: (2024-10-01)
by: Midori Yamasaki, et al.
Published: (2024-10-01)
Lixisenatide accelerates restoration of normoglycemia and improves human beta-cell function and survival in diabetic immunodeficient NOD–scid IL-2rgnull RIP-DTR mice engrafted with human islets
by: Yang C, et al.
Published: (2015-08-01)
by: Yang C, et al.
Published: (2015-08-01)
Successful Secondary Engraftment of Pancreatic Ductal Adenocarcinoma and Cholangiocarcinoma Patient-Derived Xenografts After Previous Failed Primary Engraftment
by: Matthew C. Hernandez, et al.
Published: (2019-01-01)
by: Matthew C. Hernandez, et al.
Published: (2019-01-01)
Islet Gene View—a tool to facilitate islet research
by: Olof Asplund, et al.
Published: (2022-12-01)
by: Olof Asplund, et al.
Published: (2022-12-01)
Engraftment of Insulin-Producing Cells from Porcine Islets in Non-Immune-Suppressed Rats or Nonhuman Primates Transplanted Previously with Embryonic Pig Pancreas
by: Marc R. Hammerman
Published: (2011-01-01)
by: Marc R. Hammerman
Published: (2011-01-01)
Ubiquitination-targeted therapies improve BMD iPSC myogenic cell engraftment and dystrophin expression in vivo
by: Muchen Liu, et al.
Published: (2025-09-01)
by: Muchen Liu, et al.
Published: (2025-09-01)
Effect of radiation dose-rate on hematopoietic cell engraftment in adult zebrafish.
by: Tiffany J Glass, et al.
Published: (2013-01-01)
by: Tiffany J Glass, et al.
Published: (2013-01-01)
Effective engraftment via granulocyte transfusion in pre-engraftment febrile neutropenia following allogeneic hematopoietic stem cell transplantation: granulocyte transfusion as bridge therapy
by: Neslihan Mandaci Şanli, et al.
Published: (2025-03-01)
by: Neslihan Mandaci Şanli, et al.
Published: (2025-03-01)
An improved medium formulation for efficient ex vivo gene editing, expansion and engraftment of hematopoietic stem and progenitor cells
by: Rajeev Rai, et al.
Published: (2023-06-01)
by: Rajeev Rai, et al.
Published: (2023-06-01)
Risk Factors and Options to Improve Engraftment in Unrelated Cord Blood Transplantation
by: Anna D. Petropoulou, et al.
Published: (2011-01-01)
by: Anna D. Petropoulou, et al.
Published: (2011-01-01)
Improvement of islet transplantation by the fusion of islet cells with functional blood vessels
by: Lisa Nalbach, et al.
Published: (2020-11-01)
by: Lisa Nalbach, et al.
Published: (2020-11-01)
Tagged IDS causes efficient and engraftment-independent prevention of brain pathology during lentiviral gene therapy for Mucopolysaccharidosis type II
by: Fabio Catalano, et al.
Published: (2023-12-01)
by: Fabio Catalano, et al.
Published: (2023-12-01)
Plerixafor - Does it affect engraftment kinetics?
by: Satyendra Batra, et al.
Published: (2024-01-01)
by: Satyendra Batra, et al.
Published: (2024-01-01)
Improved Baculovirus Vectors for Transduction and Gene Expression in Human Pancreatic Islet Cells
by: Leo P. Graves, et al.
Published: (2018-10-01)
by: Leo P. Graves, et al.
Published: (2018-10-01)
Similar Items
-
B7-H4 Pathway in Islet Transplantation and β-Cell Replacement Therapies
by: Xiaojie Wang, et al.
Published: (2011-01-01) -
B7-H4 Treatment of T Cells Inhibits ERK, JNK, p38, and AKT Activation.
by: Xiaojie Wang, et al.
Published: (2012-01-01) -
Advances and Challenges in Islet Transplantation: Islet Procurement Rates and Lessons Learned from Suboptimal Islet Transplantation
by: Annette Plesner, et al.
Published: (2011-01-01) -
Islet Engraftment and Revascularization in Clinical and Experimental Transplantation
by: Christian Molnár, et al.
Published: (2013-02-01) -
Generation of Transplantable Beta Cells for Patient-Specific Cell Therapy
by: Xiaojie Wang, et al.
Published: (2012-01-01)
