Expression of key cytokines in dog macrophages infected by Leishmania tarentolae opening new avenues for the protection against Leishmania infantum

Abstract The detection of Leishmania tarentolae in sympatric areas where Leishmania infantum is endemic raised questions regarding the protective effect exerted in dogs by L. tarentolae when in coinfection. This study aimed monitoring the in vitro gene expression of pro- (IFN- γ; TNF-α; IL-12) and a...

Full description

Bibliographic Details
Published in:	Scientific Reports
Main Authors:	Viviane Noll Louzada-Flores, Maria Stefania Latrofa, Jairo Alfonso Mendoza-Roldan, Maria Stella Lucente, Sara Epis, Ilaria Varotto-Boccazzi, Claudio Bandi, Domenico Otranto
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-11-01
Online Access:	https://doi.org/10.1038/s41598-024-78451-x

Similar Items

Development of a novel ddPCR assay for the simultaneous detection of the protozoan parasites Leishmania infantum and Leishmania tarentolae
by: Alessandro Alvaro, et al.
Published: (2025-07-01)

Leishmania (Leishmania) infantum and Leishmania (Sauroleishmania) tarentolae in outdoor cats and report of infection in feline-derived peripheral blood mononuclear cells
by: Jairo Alfonso Mendoza-Roldan, et al.
Published: (2025-08-01)

A novel chemically defined medium for the biotechnological and biomedical exploitation of the cell factory Leishmania tarentolae
by: Giulia Maria Cattaneo, et al.
Published: (2024-04-01)

Leishmania tarentolae: a vaccine platform to target dendritic cells and a surrogate pathogen for next generation vaccine research in leishmaniases and viral infections
by: Claudio Bandi, et al.
Published: (2023-01-01)

The non-pathogenic protozoon Leishmania tarentolae interferes with the activation of NLRP3 inflammasome in human cells: new perspectives in the control of inflammation
by: Francesca La Rosa, et al.
Published: (2024-04-01)

Assessment of the diagnostic performance of serological tests in areas where Leishmania infantum and Leishmania tarentolae occur in sympatry
by: Roberta Iatta, et al.
Published: (2023-10-01)

<i>Leishmania tarentolae</i> as an Antigen Delivery Platform: Dendritic Cell Maturation after Infection with a Clone Engineered to Express the SARS-CoV-2 Spike Protein
by: Ilaria Varotto-Boccazzi, et al.
Published: (2022-05-01)

Seasonal variation of anti-Leishmania infantum antibodies and laboratory abnormalities in dogs with leishmaniosis
by: Maria Alfonsa Cavalera, et al.
Published: (2025-08-01)

Conjunctival Swab Real Time-PCR in <i>Leishmania infantum</i> Seropositive Dogs: Diagnostic and Prognostic Values
by: Maria Alfonsa Cavalera, et al.
Published: (2022-01-01)

Genes and Chromosomes of Leishmania infantum
by: Jose María Requena, et al.
Published: (1997-11-01)

Rapid isothermal molecular tests to discriminate between Leishmania braziliensis and Leishmania infantum infections in dogs
by: Rafaela Lira Nogueira de Luna, et al.
Published: (2025-01-01)

Final comments on an interesting taxonomic dilemma: Leishmania infantum versus Leishmania infantum chagasi
by: Filipe Dantas-Torres
Published: (2006-12-01)

Evaluating the Leishmania tarentolae response to inorganic strontium-based oxyfluorides
by: Katelyn Terry, et al.
Published: (2024-05-01)

Efficacy of afoxolaner (NexGard®) in preventing the transmission of Leishmania infantum and Dirofilaria immitis to sheltered dogs in a highly endemic area
by: Rossella Panarese, et al.
Published: (2021-07-01)

Leishmania infantum and other zoonotic pathogens associated with captive lemurs (Lemur catta) in southern Italy
by: Renata Fagundes-Moreira, et al.
Published: (2025-08-01)

Rectal Administration of <i>Leishmania</i> Cells Elicits a Specific, Th1-Associated IgG2a Response in Mice: New Perspectives for Mucosal Vaccination against Leishmaniasis, after the Repurposing of a Study on an Anti-Viral Vaccine Candidate
by: Ilaria Varotto-Boccazzi, et al.
Published: (2023-08-01)

A Modular Cloning Toolkit for the production of recombinant proteins in Leishmania tarentolae
by: Katrin Hieronimus, et al.
Published: (2022-04-01)

Leishmania tarentolae as a platform for the production of vaccines against viral pathogens
by: Marta Zimna, et al.
Published: (2024-11-01)

Comparative Gene Expression Profiles of Leishmania major and Leishmania infantum Promastigotes
by: Özlem Ulusan Bağcı, et al.
Published: (2021-06-01)

Leishmania infantum versus Leishmania chagasi: do not forget the law of priority
by: Filipe Dantas-Torres
Published: (2006-02-01)

Canine antibody response to Phlebotomus perniciosus bites negatively correlates with the risk of Leishmania infantum transmission.
by: Michaela Vlkova, et al.
Published: (2011-10-01)

Isolation, characterization, and functional study of extracellular vesicles derived from Leishmania tarentolae
by: Mehrdad Shokouhy, et al.
Published: (2022-08-01)

Transcriptional signatures in human macrophage-like cells infected by Leishmania infantum, Leishmania major and Leishmania tropica.
by: Aurora Diotallevi, et al.
Published: (2024-04-01)

<it>Leishmania infantum </it>leishmaniasis in corticosteroid – treated patients
by: De Marco Michele, et al.
Published: (2006-12-01)

Investigation of the Anti-Leishmania (Leishmania) infantum Activity of Some Natural Sesquiterpene Lactones
by: Imke F. Wulsten, et al.
Published: (2017-04-01)

Leishmanicidal and Cytotoxic Activity of Algerian Medicinal Plants on Leishmania major and Leishmania infantum
by: Naouel Eddaikra, et al.
Published: (2019-07-01)

Licochalcone a Exhibits Leishmanicidal Activity in vitro and in Experimental Model of Leishmania (Leishmania) Infantum
by: Julia M. Souza, et al.
Published: (2020-12-01)

Cytokine and Phenotypic Cell Profiles of Leishmania infantum Infection in the Dog
by: Carla Maia, et al.
Published: (2012-01-01)

A case of leishmania infantum mimicking lymphoma
by: Gulnaz Culha, et al.
Published: (2023-01-01)

Mucocutaneous Leishmaniasis due to Leishmania infantum Infection
by: Kai-Philipp Linse, et al.
Published: (2022-07-01)

Leishmania (infantum) chagasi in canine urinary sediment
by: Ivete Lopes de Mendonça, et al.

New diarylsulfonamide inhibitors of Leishmania infantum amastigotes
by: Myriam González, et al.
Published: (2021-08-01)

Multilocus microsatellite typing of Leishmania infantum isolates in monitored Leishmania/HIV coinfected patients
by: Míriam Tomás-Pérez, et al.
Published: (2015-07-01)

The Antileishmanial Potential of C-3 Functionalized Isobenzofuranones against Leishmania (Leishmania) Infantum Chagasi
by: Wagner Luiz Pereira, et al.
Published: (2015-12-01)

Reproduction of Leishmania (Leishmania ) infantum chagasi in conditioned cell culture growth medium Isolamento e crescimento de Leishmania (Leishmania) infantum chagasi em meio de crescimento condicionado de cultura celular
by: Yeda L. Nogueira, et al.
Published: (2006-06-01)

Development and Validation of a PCR-ELISA for the Diagnosis of Symptomatic and Asymptomatic Infection by Leishmania (Leishmania) infantum
by: Fernanda Alvarenga Cardoso Medeiros, et al.
Published: (2017-01-01)

Production of a kinesin-related recombinant protein (Lbk39) from Leishmania braziliensis by Leishmania tarentolae promastigotes and its application in the serodiagnosis of leishmaniasis
by: Lígia Moraes Barizon de Souza, et al.
Published: (2019-12-01)

The efficacy of new 2,5-dihydroxybenzyl derivatives against Trypanosoma cruzi, Leishmania infantum and Leishmania braziliensis
by: Miriam Rolón, et al.
Published: (2019-06-01)

Oral and Intragastric: New Routes of Infection by <i>Leishmania braziliensis</i> and <i>Leishmania infantum</i>?
by: Mayra M. Reimann, et al.
Published: (2022-06-01)

A comparison of molecular markers to detect Lutzomyia longipalpis naturally infected with Leishmania (Leishmania) infantum
by: Kárita Cláudia Freitas-Lidani, et al.
Published: (2014-07-01)