Role of peripheral cytokines and orbitofrontal cortex subregion structure in schizophrenia agitation
Abstract This study aimed to examine the potential involvement of inflammatory imbalance and OFC subregion structure in the pathogenesis of agitation. In this study 119 schizophrenia patients were categorized into different subgroups of agitation using two-step cluster analysis. Peripheral cytokine...
| Published in: | Scientific Reports |
|---|---|
| Main Authors: | Yingbo Dong, Yilin Tang, Yuting Li, Peiyu Cao, Guoxin Xu, Ruiqiu Zhu, Runda Li, Yuxiu Sui |
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-04-01
|
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-99033-5 |
Similar Items
Orbitofrontal Cortex in Chronic Analgesic-Overuse Headache
by: J Gordon Millichap
Published: (2006-02-01)
by: J Gordon Millichap
Published: (2006-02-01)
The Role of the Orbitofrontal Cortex in the Regulation of Fear Coping Strategies
by: Hsun-Yi Kuan, et al.
Published: (2024-09-01)
by: Hsun-Yi Kuan, et al.
Published: (2024-09-01)
Covert shift of attention modulates the value encoding in the orbitofrontal cortex
by: Yang Xie, et al.
Published: (2018-03-01)
by: Yang Xie, et al.
Published: (2018-03-01)
Structural variations in the sulco-gyral pattern of the orbitofrontal cortex
by: Krisna Els, et al.
Published: (2021-06-01)
by: Krisna Els, et al.
Published: (2021-06-01)
Shared and unique transcriptional changes in the orbitofrontal cortex in psychiatric disorders and suicide
by: Sinead O'Donovan, et al.
Published: (2024-01-01)
by: Sinead O'Donovan, et al.
Published: (2024-01-01)
Shared and unique transcriptional changes in the orbitofrontal cortex in psychiatric disorders and suicide
by: Sinead O'Donovan, et al.
Published: (2024-01-01)
by: Sinead O'Donovan, et al.
Published: (2024-01-01)
The Orbitofrontal Cortex Gray Matter Is Associated With the Interaction Between Insomnia and Depression
by: Siyi Yu, et al.
Published: (2018-12-01)
by: Siyi Yu, et al.
Published: (2018-12-01)
Selective disruption of gray matter volume covariance in orbitofrontal cortex subregions among patients with functional constipation
by: Qian Su, et al.
Published: (2025-05-01)
by: Qian Su, et al.
Published: (2025-05-01)
Cortical Thickness of the Orbitofrontal Cortex in Patients with Alcohol Use Disorder
by: Murad Atmaca, et al.
Published: (2023-03-01)
by: Murad Atmaca, et al.
Published: (2023-03-01)
Sensation-seeking is related to functional connectivities of the medial orbitofrontal cortex with the anterior cingulate cortex
by: Zhuo Wan, MSc, et al.
Published: (2020-07-01)
by: Zhuo Wan, MSc, et al.
Published: (2020-07-01)
Olfactory consciousness and gamma oscillation couplings across the olfactory bulb, olfactory cortex and orbitofrontal cortex
by: Kensaku eMori, et al.
Published: (2013-10-01)
by: Kensaku eMori, et al.
Published: (2013-10-01)
1Hz right orbitofrontal TMS benefits depressed patients unresponsive to dorsolateral prefrontal cortex TMS
by: Amourie Prentice, et al.
Published: (2023-11-01)
by: Amourie Prentice, et al.
Published: (2023-11-01)
Reduced Age-Related Gray Matter Loss in the Orbitofrontal Cortex in Long-Term Meditators
by: Florian Kurth, et al.
Published: (2023-12-01)
by: Florian Kurth, et al.
Published: (2023-12-01)
Lateral orbitofrontal cortex promotes trial-by-trial learning of risky, but not spatial, biases
by: Christine M Constantinople, et al.
Published: (2019-11-01)
by: Christine M Constantinople, et al.
Published: (2019-11-01)
Metacognition and Its Relationship With Orbitofrontal Cortex and Thalamus Volumes in Patients With Obsessive‐Compulsive Disorder
by: Murad Atmaca, et al.
Published: (2025-08-01)
by: Murad Atmaca, et al.
Published: (2025-08-01)
Chronology of auditory processing and related co-activation in the orbitofrontal cortex depends on musical expertise
by: Steffen Bücher, et al.
Published: (2023-01-01)
by: Steffen Bücher, et al.
Published: (2023-01-01)
The road not taken: neural correlates of decision making in orbitofrontal cortex
by: Adam P. Steiner, et al.
Published: (2012-09-01)
by: Adam P. Steiner, et al.
Published: (2012-09-01)
Different activation in left dorsolateral prefrontal cortex and left orbitofrontal cortex during autobiographical memory tasks is associated with depressive disorder with different levels of resilience: a functional near-infrared spectroscopy study
by: Huifen Wu, et al.
Published: (2025-09-01)
by: Huifen Wu, et al.
Published: (2025-09-01)
Anatomical mapping of whole-brain monosynaptic inputs to the orbitofrontal cortex
by: Mei Yang, et al.
Published: (2025-04-01)
by: Mei Yang, et al.
Published: (2025-04-01)
Transcranial direct current stimulation (tDCS) over the orbitofrontal cortex reduces delay discounting
by: Andrea Stefano Moro, et al.
Published: (2023-08-01)
by: Andrea Stefano Moro, et al.
Published: (2023-08-01)
Characterizing the experience of agitation in patients with bipolar disorder and schizophrenia
by: Jenna Roberts, et al.
Published: (2018-04-01)
by: Jenna Roberts, et al.
Published: (2018-04-01)
Orbitofrontal reality filtering
by: Armin eSchnider
Published: (2013-06-01)
by: Armin eSchnider
Published: (2013-06-01)
Gray Matter Abnormalities of Orbitofrontal Cortex and Striatum in Drug-Naïve Adult Patients With Obsessive-Compulsive Disorder
by: Zhang Bowen, et al.
Published: (2021-06-01)
by: Zhang Bowen, et al.
Published: (2021-06-01)
State-specific modulation of mood using intracranial electrical stimulation of the orbitofrontal cortex
by: Dan Cao, et al.
Published: (2023-07-01)
by: Dan Cao, et al.
Published: (2023-07-01)
Terahertz photoneuromodulation of lateral orbitofrontal cortex neurons ameliorates stress-induced depression and cognitive impairment
by: Yuanyuan He, et al.
Published: (2025-03-01)
by: Yuanyuan He, et al.
Published: (2025-03-01)
Evaluation of structural changes in orbitofrontal cortex in relation to medication overuse in migraine patients: a diffusion tensor imaging study
by: Aygul Tantik Pak, et al.
Published: (2021-07-01)
by: Aygul Tantik Pak, et al.
Published: (2021-07-01)
Psychological Resilience Enhances the Orbitofrontal Network in the Elderly With Mild Cognitive Impairment
by: Sang Joon Son, et al.
Published: (2019-08-01)
by: Sang Joon Son, et al.
Published: (2019-08-01)
Opposite changes in morphometric similarity of medial reward and lateral non-reward orbitofrontal cortex circuits in obesity
by: Debo Dong, et al.
Published: (2024-04-01)
by: Debo Dong, et al.
Published: (2024-04-01)
Functional heterogeneity within the rodent lateral orbitofrontal cortex dissociates outcome devaluation and reversal learning deficits
by: Marios C Panayi, et al.
Published: (2018-07-01)
by: Marios C Panayi, et al.
Published: (2018-07-01)
Aerobic Exercise Decreases Negative Affect by Modulating Orbitofrontal-Amygdala Connectivity in Adolescents
by: Li-Kun Ge, et al.
Published: (2021-06-01)
by: Li-Kun Ge, et al.
Published: (2021-06-01)
Differential Effects of the Lateral Hypothalamus Lesion as an Origin of Orexin and Blockade of Orexin-1 Receptor in the Orbitofrontal Cortex and Anterior Cingulate Cortex on Their Neuronal Activity
by: Sara Karimi, et al.
Published: (2022-05-01)
by: Sara Karimi, et al.
Published: (2022-05-01)
Relationship between plasma TNF-α levels and agitation symptoms in first episode patients with schizophrenia
by: Xiaoying Wang, et al.
Published: (2024-07-01)
by: Xiaoying Wang, et al.
Published: (2024-07-01)
Aberrant orbitofrontal cortical activation interferes with encoding of Pavlovian fear conditioning
by: Chung-Fu Sun, et al.
Published: (2022-08-01)
by: Chung-Fu Sun, et al.
Published: (2022-08-01)
White matter disconnection and decreased functional connectivity between orbitofrontal cortex and the contralateral temporo-occipital cortex in adults with obsessive compulsive disorder
by: J. Queiroz, et al.
Published: (2021-04-01)
by: J. Queiroz, et al.
Published: (2021-04-01)
Dynamic changes in orbitofrontal-hippocampal connectivity linked to cognitive map formation in humans
by: Yidan Qiu, et al.
Published: (2025-09-01)
by: Yidan Qiu, et al.
Published: (2025-09-01)
Reconceptualizing anhedonia: novel perspectives on balancing the pleasure networks in the human brain
by: Kristine eRømer Thomsen, et al.
Published: (2015-03-01)
by: Kristine eRømer Thomsen, et al.
Published: (2015-03-01)
Responding to preconditioned cues is devaluation sensitive and requires orbitofrontal cortex during cue-cue learning
by: Evan E Hart, et al.
Published: (2020-08-01)
by: Evan E Hart, et al.
Published: (2020-08-01)
Cortico-Striatal-Thalamic Loop Circuits of the Orbitofrontal Cortex: Promising Therapeutic Targets in Psychiatric Illness
by: Jonathan Downar, et al.
Published: (2017-04-01)
by: Jonathan Downar, et al.
Published: (2017-04-01)
Optogenetic inhibition of ventrolateral orbitofrontal cortex astrocytes facilitates ventrolateral periaqueductal gray glutamatergic activity to reduce hypersensitivity in infraorbital nerve injury rat model
by: Jaisan Islam, et al.
Published: (2025-02-01)
by: Jaisan Islam, et al.
Published: (2025-02-01)
Medial Orbitofrontal De-Activation During Tonic Cold Pain Stimulation: A fMRI Study Examining the Opponent-Process Theory
by: Bitar N, et al.
Published: (2020-06-01)
by: Bitar N, et al.
Published: (2020-06-01)
Similar Items
-
Orbitofrontal Cortex in Chronic Analgesic-Overuse Headache
by: J Gordon Millichap
Published: (2006-02-01) -
The Role of the Orbitofrontal Cortex in the Regulation of Fear Coping Strategies
by: Hsun-Yi Kuan, et al.
Published: (2024-09-01) -
Covert shift of attention modulates the value encoding in the orbitofrontal cortex
by: Yang Xie, et al.
Published: (2018-03-01) -
Structural variations in the sulco-gyral pattern of the orbitofrontal cortex
by: Krisna Els, et al.
Published: (2021-06-01) -
Shared and unique transcriptional changes in the orbitofrontal cortex in psychiatric disorders and suicide
by: Sinead O'Donovan, et al.
Published: (2024-01-01)
