Farnesol Ameliorates Demyelinating Phenotype in a Cellular and Animal Model of Charcot-Marie-Tooth Disease Type 1A

Charcot-Marie-Tooth disease (CMT) is a genetically heterogeneous disease affecting the peripheral nervous system that is caused by either the demyelination of Schwann cells or degeneration of the peripheral axon. Currently, there are no treatment options to improve the degeneration of peripheral ner...

Full description

Bibliographic Details
Published in:	Current Issues in Molecular Biology
Main Authors:	Na-Young Park, Geon Kwak, Hyun-Myung Doo, Hye-Jin Kim, So-Young Jang, Yun-Il Lee, Byung-Ok Choi, Young-Bin Hong
Format:	Article
Language:	English
Published:	MDPI AG 2021-11-01
Subjects:	Charcot-Marie-Tooth disease (CMT) farnesol myelination
Online Access:	https://www.mdpi.com/1467-3045/43/3/138

Similar Items

Proposal of physical exercises for charcot marie tooth disease patients: a tailored approach
by: Alice Meloni, et al.
Published: (2023-10-01)

Modeling of Charcot-Marie-Tooth disease in zebrafish
by: Małgorzata Korzeniowska née Wiweger, et al.
Published: (2025-08-01)

Intraoperative diagnosis of autonomic neuropathy in a case of Charcot–Marie–Tooth disease undergoing laparoscopic cholecystectomy: A case report
by: Kazi Mahzabin Arin, et al.
Published: (2024-05-01)

Neurofilaments in health and Charcot-Marie-Tooth disease
by: Farah Kotaich, et al.
Published: (2023-12-01)

Genetic Workup for Charcot–Marie–Tooth Neuropathy: A Retrospective Single-Site Experience Covering 15 Years
by: Chiara Gemelli, et al.
Published: (2022-03-01)

Pé cavo adquirido na doença de Charcot-Marie-Tooth Acquired pes cavus in Charcot-Marie-Tooth disease
by: Daniel Augusto Carvalho Maranho, et al.
Published: (2009-01-01)

Pain in Charcot-Marie-Tooth disease: an update
by: Helen Azevedo, et al.

Clinical and genetic aspects of Charcot-Marie-Tooth disease subtypes
by: Soo Hyun Nam, et al.
Published: (2019-06-01)

Clinical and neurophysiological investigation of a large family with dominant Charcot-Marie-Tooth type 2 disease with pyramidal signs
by: Eduardo Luis de Aquino Neves, et al.
Published: (2011-06-01)

Doença de Charcot-Marie-Tooth: estudos eletromiográficos em 45 pacientes Charcot-Marie-Tooth disease: electromyographic studies in 45 cases
by: Marcos R.G. Freitas, et al.
Published: (1995-09-01)

Doença de Charcot-Marie-Tooth: estudo clínico em 45 pacientes Charcot-Marie-Tooth disease: clinical features in 45 cases
by: Marcos R. G. de freitas, et al.
Published: (1995-09-01)

Case report: A novel variant (H49N) in Myelin Protein Zero gene is responsible for a patient with Charcot–Marie–Tooth disease
by: Gao-Hui Cao, et al.
Published: (2024-02-01)

Molecular Diagnosis of Charcot-Marie Tooth Disease
by: J. Gordon Millichap
Published: (2002-02-01)

Frecuencia del alelo causante de la enfermedad de Charcot-Marie-Tooth (tipo axonal con herencia autosómica recesiva) en Palmares, Costa Rica
by: Melissa Rojas-Araya, et al.
Published: (2009-11-01)

Prevalence and characterization of pain in patients with Charcot-Marie-Tooth disease type 1A
by: Helen AZEVEDO, et al.
Published: (2021-05-01)

Increased BNIP3-mediated mitophagy attenuates GDAP1 loss of function - implications for Charcot-Marie-Tooth disease 4A
by: Li Zhang, et al.
Published: (2025-09-01)

Ferroptosis and Charcot–Marie–Tooth Disease 1A: Emerging Evidence for a Pathogenic Association
by: Jacob B. White, et al.
Published: (2025-03-01)

Charcot-Marie-Tooth Disease Subtypes and Genetics
by: J Gordon Millichap
Published: (2011-03-01)

Early Onset Charcot-Marie-Tooth Disease
by: J Gordon Millichap
Published: (2005-06-01)

CASE REPORT OF ADULT-ONSET CHARCOT MARIE TOOTH TYPE X
by: Richard Suherlim, et al.
Published: (2022-01-01)

Ascorbic Acid in Charcot-Marie-Tooth Disease
by: J Gordon Millichap
Published: (2009-12-01)

Frecuencia del alelo causante de la enfermedad de Charcot-Marie-Tooth (tipo axonal con herencia autosómica recesiva) en Palmares, Costa Rica
by: Melissa Rojas-Araya, et al.
Published: (2009-11-01)

Quality of life in patients with Charcot-Marie-Tooth disease type 1A Análise da qualidade de vida de pacientes com a doença de Charcot-Marie-Tooth tipo 1A
by: Juliana B. Taniguchi, et al.
Published: (2013-06-01)

Physiotherapy of Charcot–Marie–Tooth disease
by: N. A. Shnayder, et al.
Published: (2015-02-01)

Genetics of Charcot-Marie-Tooth Disease
by: J Gordon Millichap
Published: (1998-05-01)

POLG1 Mutations and Charcot-Marie-Tooth Disease
by: J Gordon Millichap
Published: (2008-02-01)

Doença de Charcot-Marie-Tooth: estudo da biópsia do nervo sural em 41 pacientes Charcot-Marie-Tooth disease: sural nerve biopsy findings in 41 patients
by: Marcos R.G. Freitas, et al.
Published: (1995-09-01)

Plantar Pressure Distribution in Charcot–Marie–Tooth Disease: A Systematic Review
by: Alberto Arceri, et al.
Published: (2025-07-01)

Hip Dysplasia in Patients with Charcot-Marie-Tooth Disease: Unraveling an Underrecognized Condition
by: Nathan Chaclas, BS, et al.
Published: (2024-08-01)

Acute adrenal insufficiency-induced hypotension following spinal surgery in a pediatric patient with Charcot-Marie-Tooth disease and severe scoliosis: a case report
by: Jiang Cao, et al.
Published: (2025-07-01)

Current Treatment Methods for Charcot–Marie–Tooth Diseases
by: Hongxian Dong, et al.
Published: (2024-09-01)

Evaluation of life quality in patients with hereditary neuropathy Charcot—Marie—Tooth in the Krasnoyarsk Region
by: N. A. Shnayder, et al.
Published: (2011-04-01)

A double-blind, placebo-controlled, randomized trial of PXT3003 for the treatment of Charcot–Marie–Tooth type 1A
by: Shahram Attarian, et al.
Published: (2021-10-01)

Charcot-Marie-Tooth disease and dilated cardiomyopathy. A rare combination.
by: Rafael Pila Pérez, et al.
Published: (2011-07-01)

Biomechanical effects of sensorimotor orthoses in adults with Charcot‐Marie‐Tooth disease
by: Caleb Wegener, et al.
Published: (2015-01-01)

A Novel Family with Demyelinating Charcot–Marie–Tooth Disease Caused by a Mutation in the PMP2 Gene: A Case Series of Nine Patients and a Brief Review of the Literature
by: Margherita Baga, et al.
Published: (2023-05-01)

Organization experience of diagnostic and medicosocial services for patients with Charcot—Marie—Tooth disease in Krasnoyarsk region
by: E. V. Glushchenko, et al.
Published: (2015-02-01)

One Multilocus Genomic Variation Is Responsible for a Severe Charcot–Marie–Tooth Axonal Form
by: Federica Miressi, et al.
Published: (2020-12-01)

Osteocondrite dissecante de patela em paciente com doença de Charcot-Marie-Tooth
by: Ítalo Tadeu Sousa Cruz de Amorim, et al.
Published: (2023-02-01)

Quality of life in patients with Charcot-Marie-Tooth disease type 1A
by: Juliana B. Taniguchi, et al.
Published: (2013-06-01)