The Emerging Role of CKAP4 in GI Cancer: From Molecular Pathways to Clinical Applications
Cytoskeleton-associated protein 4 (CKAP4) has emerged as a critical player in gastrointestinal (GI) cancer progression, diagnosis, and therapy. This comprehensive review synthesizes current knowledge on CKAP4′s multifaceted roles across GI malignancies, providing novel insights into its mechanisms o...
| Published in: | Current Oncology |
|---|---|
| Main Authors: | Markos Despotidis, Orestis Lyros, Tatiana S. Driva, Panagiotis Sakarellos, René Thieme, Andreas Mamilos, Stratigoula Sakellariou, Dimitrios Schizas |
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-10-01
|
| Subjects: | |
| Online Access: | https://www.mdpi.com/1718-7729/32/10/561 |
Similar Items
CKAP2 and malignant tumors
Published: (2024-10-01)
Published: (2024-10-01)
DKK1 and Its Receptors in Esophageal Adenocarcinoma: A Promising Molecular Target
by: Markos Despotidis, et al.
Published: (2025-01-01)
by: Markos Despotidis, et al.
Published: (2025-01-01)
Prognostic significance of CKAP2L expression in patients with clear cell renal cell carcinoma
by: Zhi Liu, et al.
Published: (2023-01-01)
by: Zhi Liu, et al.
Published: (2023-01-01)
The Role of Serum Dickkopf1 and CKAP4 Levels in Diagnosing Colorectal Cancer and Measuring the Disease Severity: A Prospective Study
by: Esra Dişçi, et al.
Published: (2024-06-01)
by: Esra Dişçi, et al.
Published: (2024-06-01)
CKAP4 and PLOD2 as novel prognostic biomarkers in hepatocellular carcinoma: a proteomics-driven risk stratification model
by: Qiulong Lu, et al.
Published: (2025-07-01)
by: Qiulong Lu, et al.
Published: (2025-07-01)
LRRC59 promotes the progression of oral squamous cell carcinoma by interacting with SRP pathway components and enhancing the secretion of CKAP4-containing exosomes
by: Qijun Sun, et al.
Published: (2024-03-01)
by: Qijun Sun, et al.
Published: (2024-03-01)
Smoking promotes the progression of bladder cancer through FOXM1/CKAP2L axis
by: Feixiang Wu, et al.
Published: (2025-07-01)
by: Feixiang Wu, et al.
Published: (2025-07-01)
Identification and validation of CKAP2 as a novel biomarker in the development and progression of rheumatoid arthritis
by: Qiongbing Zheng, et al.
Published: (2025-06-01)
by: Qiongbing Zheng, et al.
Published: (2025-06-01)
DKK3 as a diagnostic marker and potential therapeutic target for sarcopenia in chronic obstructive pulmonary disease
by: Zilin Wang, et al.
Published: (2024-12-01)
by: Zilin Wang, et al.
Published: (2024-12-01)
CircZNF609 as a prototype to elucidate the biological function of circRNA-mRNA interactions
by: Manuel Beltran, et al.
Published: (2022-12-01)
by: Manuel Beltran, et al.
Published: (2022-12-01)
New Development of Biomarkers for Gastrointestinal Cancers: From Neoplastic Cells to Tumor Microenvironment
by: Jiajia Zhang, et al.
Published: (2018-08-01)
by: Jiajia Zhang, et al.
Published: (2018-08-01)
Circulating tumour cell enumeration, biomarker analyses, and kinetics in patients with colorectal cancer and other GI malignancies
by: Walla Malkawi, et al.
Published: (2023-11-01)
by: Walla Malkawi, et al.
Published: (2023-11-01)
Progastrin: An Overview of Its Crucial Role in the Tumorigenesis of Gastrointestinal Cancers
by: Rodanthi Fioretzaki, et al.
Published: (2024-04-01)
by: Rodanthi Fioretzaki, et al.
Published: (2024-04-01)
The Grand Challenges in GI Tract Cancers
by: Mauro eRisio
Published: (2011-11-01)
by: Mauro eRisio
Published: (2011-11-01)
Biological roles and potential clinical value of tRNA-derived small RNAs in gastrointestinal malignancies
by: Yongfu Shao, et al.
Published: (2025-12-01)
by: Yongfu Shao, et al.
Published: (2025-12-01)
Lipid Metabolism in Gastrointestinal Malignancies: Exploring Dysregulation, Biomarkers, and Treatment Strategies
by: Yan An, et al.
Published: (2025-05-01)
by: Yan An, et al.
Published: (2025-05-01)
Pigment Epithelial-Derived Factor in Pancreatic and Liver Cancers—From Inflammation to Cancer
by: Sara Pączek, et al.
Published: (2024-10-01)
by: Sara Pączek, et al.
Published: (2024-10-01)
Senescence Biomarkers CKAP4 and PTX3 Stratify Severe Kidney Disease Patients
by: Sean McCallion, et al.
Published: (2024-09-01)
by: Sean McCallion, et al.
Published: (2024-09-01)
The Role of Omentin in Gastrointestinal Cancer: Diagnostic, Prognostic, and Therapeutic Perspectives
by: Adam Mylonakis, et al.
Published: (2025-09-01)
by: Adam Mylonakis, et al.
Published: (2025-09-01)
GI Biopsy Crash Course
by: Jeremy Parfitt, et al.
Published: (2014-10-01)
by: Jeremy Parfitt, et al.
Published: (2014-10-01)
Recent advances in the systemic treatment of gastrointestinal malignancy
by: Ravi Kumar Paluri, et al.
Published: (2019-01-01)
by: Ravi Kumar Paluri, et al.
Published: (2019-01-01)
Editorial: New immunotherapy strategies and related therapeutic targets for gastrointestinal malignancies
by: Ganesan Ramamoorthi
Published: (2024-03-01)
by: Ganesan Ramamoorthi
Published: (2024-03-01)
Differential diagnosis of gastrointestinal stromal tumors versus leiomyomas by special stains
by: Shiwei Zhang, et al.
Published: (2024-11-01)
by: Shiwei Zhang, et al.
Published: (2024-11-01)
Gastric glomus tumor with uncertain malignant potential: case report of a rare cause of upper gastrointestinal bleeding
by: Roland Fejes, et al.
Published: (2024-11-01)
by: Roland Fejes, et al.
Published: (2024-11-01)
A Novel Multidisciplinary Team Activation for Patients with Severe Gastrointestinal Bleeding: Creation of the Code GI Bleed Protocol
by: Baugh CW, et al.
Published: (2023-04-01)
by: Baugh CW, et al.
Published: (2023-04-01)
ASSOCIATION BETWEEN PHENOTYPE OF PERIPHERAL MONONUCLEAR CELLS AND HISTOPATHOLOGIC FEATURES OF GASTROINTESTINAL MALIGNANСIES
by: A. I. Autenshlus, et al.
Published: (2014-07-01)
by: A. I. Autenshlus, et al.
Published: (2014-07-01)
Complete Mesocolic Excision for Colon Cancer: The New Standard of Care?
by: Saumitra Rawat, et al.
Published: (2024-10-01)
by: Saumitra Rawat, et al.
Published: (2024-10-01)
Clinical experience in diagnosis and treatment of malignant gastrointestinal stromal tumors
by: Fan Lin, et al.
Published: (2012-04-01)
by: Fan Lin, et al.
Published: (2012-04-01)
The Future of Minimally Invasive GI and Capsule Diagnostics (REFLECT), October 2024
by: Lea Østergaard Hansen, et al.
Published: (2025-03-01)
by: Lea Østergaard Hansen, et al.
Published: (2025-03-01)
Biomarkers in Early Detection, Prognostication and Management of Gastrointestinal Tract Malignancies: A Review
by: K. Atoe, et al.
Published: (2024-09-01)
by: K. Atoe, et al.
Published: (2024-09-01)
Gastric cystica profunda with upper GI bleeding
by: Rongbao Jia, et al.
Published: (2023-09-01)
by: Rongbao Jia, et al.
Published: (2023-09-01)
Editorial: Gastrointestinal (GI) disorders and antioxidant therapeutics
by: Dipak Kumar Sahoo, et al.
Published: (2025-03-01)
by: Dipak Kumar Sahoo, et al.
Published: (2025-03-01)
Case series: Clinico-pathological studies of gastrointestinal neuroendocrine tumors (GI-NETs)
by: Akilandeswari Alagan Ramasamy, et al.
Published: (2023-12-01)
by: Akilandeswari Alagan Ramasamy, et al.
Published: (2023-12-01)
Intrahepatic aneurysm in a branch of the right hepatic artery in a patient with vasculitis due to systemic lupus erythematosus
by: Zoi Nitsa, et al.
Published: (2024-03-01)
by: Zoi Nitsa, et al.
Published: (2024-03-01)
Small intestinal metastasis combined with intussusception after surgery for breast tumor
by: Chuying Wu, et al.
Published: (2022-08-01)
by: Chuying Wu, et al.
Published: (2022-08-01)
ANALYSIS OF INCIDENCE AND MORTALITY OF GASTROINTESTINAL MALIGNANT TUMORS IN UKRAINE AND WORLDWIDE
by: Valeriy Zub
Published: (2022-12-01)
by: Valeriy Zub
Published: (2022-12-01)
A study on histomorphological spectrum of esophageo-gastrointestinal malignancies
by: Karthik LR, et al.
Published: (2024-01-01)
by: Karthik LR, et al.
Published: (2024-01-01)
Role of Intestinal Microbiota in the Pathogenesis of Colorectal Cancer: A Narrative Review
by: Sharanya Menon, et al.
Published: (2024-01-01)
by: Sharanya Menon, et al.
Published: (2024-01-01)
Analysis Of Gastrointestinal Malignancy: A Five Years Study
by: Mandakini M Patel, et al.
Published: (2012-09-01)
by: Mandakini M Patel, et al.
Published: (2012-09-01)
Updates and Expert Opinions on Liver Transplantation for Gastrointestinal Malignancies
by: Alexander H. Shannon, et al.
Published: (2023-07-01)
by: Alexander H. Shannon, et al.
Published: (2023-07-01)
Similar Items
-
CKAP2 and malignant tumors
Published: (2024-10-01) -
DKK1 and Its Receptors in Esophageal Adenocarcinoma: A Promising Molecular Target
by: Markos Despotidis, et al.
Published: (2025-01-01) -
Prognostic significance of CKAP2L expression in patients with clear cell renal cell carcinoma
by: Zhi Liu, et al.
Published: (2023-01-01) -
The Role of Serum Dickkopf1 and CKAP4 Levels in Diagnosing Colorectal Cancer and Measuring the Disease Severity: A Prospective Study
by: Esra Dişçi, et al.
Published: (2024-06-01) -
CKAP4 and PLOD2 as novel prognostic biomarkers in hepatocellular carcinoma: a proteomics-driven risk stratification model
by: Qiulong Lu, et al.
Published: (2025-07-01)
