Inflammatory myofibroblastic tumors in children: clinical characteristics and treatment outcomes with a focus on targeted therapies
Background. Inflammatory myofibroblastic tumors (IMTs) are rare neoplasms in children. Traditionally, surgical resection has been the primary treatment modality with limited efficacy reported for conventional chemotherapy and radiation therapy. Recently, targeted therapies have emerged as potential...
| Published in: | The Turkish Journal of Pediatrics |
|---|---|
| Main Authors: | Ülkü Miray Yıldırım, Rejin Kebudi, Bülent Zülfikar, Bilge Bilgiç |
| Format: | Article |
| Language: | English |
| Published: |
Hacettepe University Institute of Child Health
2025-02-01
|
| Subjects: | |
| Online Access: | https://turkjpediatr.org/article/view/5463 |
Similar Items
Case report: Musculoskeletal metastastic inflammatory myofibroblastic tumor (IMT) treated by sequential ALK-TKI with longterm response
by: Thomas Cochin, et al.
Published: (2025-01-01)
by: Thomas Cochin, et al.
Published: (2025-01-01)
Novel PLEC-EML4-ALK Double Fusion Underlying Crizotinib Resistance in a Metastatic Inflammatory Myofibroblastic Tumor: A Case Report
by: Alessandra Maleddu, MD, et al.
Published: (2025-05-01)
by: Alessandra Maleddu, MD, et al.
Published: (2025-05-01)
Alectinib versus crizotinib in ALK‐positive advanced non‐small cell lung cancer and comparison of next‐generation TKIs after crizotinib failure: Real‐world evidence
by: Yurong Wang, et al.
Published: (2022-12-01)
by: Yurong Wang, et al.
Published: (2022-12-01)
Role and targeting of anaplastic lymphoma kinase in cancer
by: Carminia Maria Della Corte, et al.
Published: (2018-02-01)
by: Carminia Maria Della Corte, et al.
Published: (2018-02-01)
Renal Inflammatory Myofibroblastic Tumor in an Infant: Case Report with Review of Literature
by: Vinayak Dave, et al.
by: Vinayak Dave, et al.
CLINICAL EFFICACY OF TARGETED THERAPY TOWARDS METASTATIC LUNG CANCER CARRYING DISTINCT TYPES OF ALK REARRANGEMENTS
by: N. V. Mitiushkina, et al.
Published: (2020-09-01)
by: N. V. Mitiushkina, et al.
Published: (2020-09-01)
A retrospective study of alectinib versus ceritinib in patients with advanced non–small-cell lung cancer of anaplastic lymphoma kinase fusion in whom crizotinib treatment failed
by: Chih-Hsi Scott Kuo, et al.
Published: (2021-03-01)
by: Chih-Hsi Scott Kuo, et al.
Published: (2021-03-01)
Case Report: Clinical response to anaplastic lymphoma kinase inhibitor-based targeted therapy in uterine inflammatory myofibroblastic tumor harboring ALK-IGFBP5 fusion
by: Ting Zhao, et al.
Published: (2023-03-01)
by: Ting Zhao, et al.
Published: (2023-03-01)
Inflammatory Myofibroblastic Tumor of the Upper Airways Harboring a New TRAF3-ALK Fusion Transcript
by: Valentina Di Ruscio, et al.
Published: (2021-06-01)
by: Valentina Di Ruscio, et al.
Published: (2021-06-01)
ALK-negative inflammatory myofibroblastic tumor of the lung: A case report
by: Enze Wang, et al.
Published: (2025-04-01)
by: Enze Wang, et al.
Published: (2025-04-01)
New Perspectives in the Treatment of Inflammatory Myofibroblastic Tumor with ALK Translocation: Case Report
by: Johana Benedetti Pedroza, et al.
Published: (2024-07-01)
by: Johana Benedetti Pedroza, et al.
Published: (2024-07-01)
Radiologic findings of an adolescent epithelioid inflammatory myofibroblastic sarcoma
by: David Zezoff, DO, et al.
Published: (2024-12-01)
by: David Zezoff, DO, et al.
Published: (2024-12-01)
Inflammatory myofibroblastic tumor of the submandibular gland Harboring MSN-ALK gene fusion: A case report and literature review
by: Limei Diao, et al.
Published: (2023-12-01)
by: Limei Diao, et al.
Published: (2023-12-01)
Placenta-associated uterine inflammatory myofibroblastic tumor with a novel FBLN1-ALK1 fusion
by: Jaclyn C. Watkins, et al.
Published: (2022-06-01)
by: Jaclyn C. Watkins, et al.
Published: (2022-06-01)
Surgical treatment of uterine inflammatory myofibroblastic tumor with local invasion: A case report
by: Dan Mu, et al.
Published: (2025-02-01)
by: Dan Mu, et al.
Published: (2025-02-01)
A rare association of tuberous sclerosis complex with inflammatory myofibroblastic tumours of the sinonasal cavities: a case report
by: Mohammed Rami, et al.
Published: (2025-08-01)
by: Mohammed Rami, et al.
Published: (2025-08-01)
Recurrent uterine inflammatory myofibroblastic tumor previously managed as leiomyosarcoma has sustained response to alectinib
by: Erica V. Carballo, et al.
Published: (2022-10-01)
by: Erica V. Carballo, et al.
Published: (2022-10-01)
Inflammatory myofibroblastic tumor of the thyroid gland
by: Yiyang Zhang, et al.
Published: (2023-05-01)
by: Yiyang Zhang, et al.
Published: (2023-05-01)
Rare giant epithelioid inflammatory myofibroblastic sarcoma of the abdominal cavity in a child: a case report and review of the literature
by: Jinzhou Li, et al.
Published: (2024-12-01)
by: Jinzhou Li, et al.
Published: (2024-12-01)
Inflammatory myofibroblastic tumor of female genital tract with unusual features and potential diagnostic pitfalls
by: Huibin Zhang, et al.
Published: (2025-10-01)
by: Huibin Zhang, et al.
Published: (2025-10-01)
Case Report: Intestinal metastasis from ALK-rearranged pulmonary pleomorphic carcinomas mimicking inflammatory myofibroblastic tumors
by: Changle Shi, et al.
Published: (2025-03-01)
by: Changle Shi, et al.
Published: (2025-03-01)
Successful Conversion Surgery after Ceritinib Monotherapy in a Patient with Advanced Inflammatory Myofibroblastic Tumor Harboring SQSTM1-ALK fusion
by: Qi-An Wang, et al.
Published: (2024-06-01)
by: Qi-An Wang, et al.
Published: (2024-06-01)
Aggressive inflammatory myofibroblastic tumor of the tongue (clinical case)
by: A. P. Polyakov, et al.
Published: (2020-02-01)
by: A. P. Polyakov, et al.
Published: (2020-02-01)
Thoracic epithelioid inflammatory myofibroblastic sarcoma: a rare and aggressive disease with case report and literature review
by: Linke Yang, et al.
Published: (2024-09-01)
by: Linke Yang, et al.
Published: (2024-09-01)
Traumatic tumor hemorrhage of inflammatory myofibroblastic tumor of the lung
by: Takashi Yamashita, et al.
Published: (2024-01-01)
by: Takashi Yamashita, et al.
Published: (2024-01-01)
The Emerging Therapeutic Landscape of ALK Inhibitors in Non-Small Cell Lung Cancer
by: Valerio Gristina, et al.
Published: (2020-12-01)
by: Valerio Gristina, et al.
Published: (2020-12-01)
Inflammatory myofibroblastic tumors of the bladder in a 20-year-old female
by: Yijie Liu, et al.
Published: (2023-12-01)
by: Yijie Liu, et al.
Published: (2023-12-01)
Novel ALK gene mutation in inflammatory myofibroblastic tumor of the thyroid: a case report
by: Yang Guangxu, et al.
Published: (2025-06-01)
by: Yang Guangxu, et al.
Published: (2025-06-01)
Inflammatory Myofibroblastic Tumor
by: R. Hodan, et al.
Published: (2006-12-01)
by: R. Hodan, et al.
Published: (2006-12-01)
Cost-Effectiveness Analysis Of Ceritinib And Alectinib Versus Crizotinib In The Treatment Of Anaplastic Lymphoma Kinase-Positive Advanced Non-Small Cell Lung Cancer
by: Liu M, et al.
Published: (2019-10-01)
by: Liu M, et al.
Published: (2019-10-01)
Anaplastic lymphoma kinase-positive inflammatory myofibroblastic tumor of the breast: a case report and review of the literature
by: Yasutaka Kawakita, et al.
Published: (2023-09-01)
by: Yasutaka Kawakita, et al.
Published: (2023-09-01)
Inflammatory myofibroblastic tumors in children: a single-center retrospective study of clinical features, management, and outcomes
by: FeiYue Guo, et al.
Published: (2025-09-01)
by: FeiYue Guo, et al.
Published: (2025-09-01)
Gastric and cardiac inflammatory myofibroblastic tumor: an extremely rare case
by: Yueqi Huang, et al.
Published: (2024-01-01)
by: Yueqi Huang, et al.
Published: (2024-01-01)
Podcast on Emerging Treatment Options for Pediatric Patients with ALK-Positive Anaplastic Large Cell Lymphoma and Inflammatory Myofibroblastic Tumors
by: Eric Lowe, et al.
Published: (2024-04-01)
by: Eric Lowe, et al.
Published: (2024-04-01)
Abdominopelvic inflammatory myofibroblastic tumor that metastasized to the vertebrae and liver: A case report and review of the literature
by: Sharon Kim, et al.
Published: (2015-04-01)
by: Sharon Kim, et al.
Published: (2015-04-01)
Inflammatory Myofibroblastic Tumor of the Gallblader
by: İsmail Özsan, et al.
Published: (2013-09-01)
by: İsmail Özsan, et al.
Published: (2013-09-01)
Inflammatory myofibroblastic tumor in the liver after bone marrow transplantation: case report and literature review
by: Shuhui Yang, et al.
Published: (2025-03-01)
by: Shuhui Yang, et al.
Published: (2025-03-01)
Inflammatory myofibroblastic tumor of the prostate
by: Ken Fukiage, et al.
Published: (2024-03-01)
by: Ken Fukiage, et al.
Published: (2024-03-01)
Modern treatment of ALK-positive non-small cell lung cancer
by: D. A. Kharagezov, et al.
Published: (2022-06-01)
by: D. A. Kharagezov, et al.
Published: (2022-06-01)
Case Report: Clinical response of ensartinib for inflammatory myofibroblastic tumor of the urinary bladder with multiple metastases and TPM4-ALK fusion
by: Hongtao Ren, et al.
Published: (2025-05-01)
by: Hongtao Ren, et al.
Published: (2025-05-01)
Similar Items
-
Case report: Musculoskeletal metastastic inflammatory myofibroblastic tumor (IMT) treated by sequential ALK-TKI with longterm response
by: Thomas Cochin, et al.
Published: (2025-01-01) -
Novel PLEC-EML4-ALK Double Fusion Underlying Crizotinib Resistance in a Metastatic Inflammatory Myofibroblastic Tumor: A Case Report
by: Alessandra Maleddu, MD, et al.
Published: (2025-05-01) -
Alectinib versus crizotinib in ALK‐positive advanced non‐small cell lung cancer and comparison of next‐generation TKIs after crizotinib failure: Real‐world evidence
by: Yurong Wang, et al.
Published: (2022-12-01) -
Role and targeting of anaplastic lymphoma kinase in cancer
by: Carminia Maria Della Corte, et al.
Published: (2018-02-01) -
Renal Inflammatory Myofibroblastic Tumor in an Infant: Case Report with Review of Literature
by: Vinayak Dave, et al.
