DNA and RNA Methylation in Rheumatoid Arthritis—A Narrative Review
Rheumatoid arthritis (RA) is a progressive autoimmune disease leading to structural and functional joint damage and, eventually, to physical disability. The pathogenesis of the disease is highly complex and involves interactions between fibroblast-like synoviocytes (FLSs) and immune cells, which sti...
| Published in: | Epigenomes |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-01-01
|
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4655/9/1/2 |
| _version_ | 1849422353596940288 |
|---|---|
| author | Kajetan Kiełbowski Estera Bakinowska Anna Gorący-Rosik Karolina Figiel Roksana Judek Jakub Rosik Paweł Dec Andrzej Modrzejewski Andrzej Pawlik |
| author_facet | Kajetan Kiełbowski Estera Bakinowska Anna Gorący-Rosik Karolina Figiel Roksana Judek Jakub Rosik Paweł Dec Andrzej Modrzejewski Andrzej Pawlik |
| author_sort | Kajetan Kiełbowski |
| collection | DOAJ |
| container_title | Epigenomes |
| description | Rheumatoid arthritis (RA) is a progressive autoimmune disease leading to structural and functional joint damage and, eventually, to physical disability. The pathogenesis of the disease is highly complex and involves interactions between fibroblast-like synoviocytes (FLSs) and immune cells, which stimulate the secretion of pro-inflammatory factors, leading to chronic inflammation. In recent years, studies have demonstrated the importance of epigenetics in RA. Specifically, epigenetic alterations have been suggested to serve as diagnostic and treatment biomarkers, while epigenetic mechanisms are thought to be involved in the pathogenesis of RA. Epigenetic regulators coordinate gene expression, and in the case of inflammatory diseases, they regulate the expression of a broad range of inflammatory molecules. In this review, we discuss current evidence on the involvement of DNA and RNA methylation in RA. |
| format | Article |
| id | doaj-art-0dce697cab5b4f71ac36ecb0ee53e5b1 |
| institution | Directory of Open Access Journals |
| issn | 2075-4655 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| spelling | doaj-art-0dce697cab5b4f71ac36ecb0ee53e5b12025-08-20T03:43:30ZengMDPI AGEpigenomes2075-46552025-01-0191210.3390/epigenomes9010002DNA and RNA Methylation in Rheumatoid Arthritis—A Narrative ReviewKajetan Kiełbowski0Estera Bakinowska1Anna Gorący-Rosik2Karolina Figiel3Roksana Judek4Jakub Rosik5Paweł Dec6Andrzej Modrzejewski7Andrzej Pawlik8Department of Physiology, Pomeranian Medical University, 70-111 Szczecin, PolandDepartment of Physiology, Pomeranian Medical University, 70-111 Szczecin, PolandDepartment of Clinical and Molecular Biochemistry, Pomeranian Medical University, 70-111 Szczecin, PolandDepartment of Physiology, Pomeranian Medical University, 70-111 Szczecin, PolandDepartment of Physiology, Pomeranian Medical University, 70-111 Szczecin, PolandDepartment of Physiology, Pomeranian Medical University, 70-111 Szczecin, PolandDepartment of Plastic and Reconstructive Surgery, 109 Military Hospital, 71-422 Szczecin, PolandClinical Department of General Surgery, Pomeranian Medical University in Szczecin, Piotra Skargi 9-11, 70-965 Szczecin, PolandDepartment of Physiology, Pomeranian Medical University, 70-111 Szczecin, PolandRheumatoid arthritis (RA) is a progressive autoimmune disease leading to structural and functional joint damage and, eventually, to physical disability. The pathogenesis of the disease is highly complex and involves interactions between fibroblast-like synoviocytes (FLSs) and immune cells, which stimulate the secretion of pro-inflammatory factors, leading to chronic inflammation. In recent years, studies have demonstrated the importance of epigenetics in RA. Specifically, epigenetic alterations have been suggested to serve as diagnostic and treatment biomarkers, while epigenetic mechanisms are thought to be involved in the pathogenesis of RA. Epigenetic regulators coordinate gene expression, and in the case of inflammatory diseases, they regulate the expression of a broad range of inflammatory molecules. In this review, we discuss current evidence on the involvement of DNA and RNA methylation in RA.https://www.mdpi.com/2075-4655/9/1/2rheumatoid arthritisepigeneticsDNA methylationRNA methylation |
| spellingShingle | Kajetan Kiełbowski Estera Bakinowska Anna Gorący-Rosik Karolina Figiel Roksana Judek Jakub Rosik Paweł Dec Andrzej Modrzejewski Andrzej Pawlik DNA and RNA Methylation in Rheumatoid Arthritis—A Narrative Review rheumatoid arthritis epigenetics DNA methylation RNA methylation |
| title | DNA and RNA Methylation in Rheumatoid Arthritis—A Narrative Review |
| title_full | DNA and RNA Methylation in Rheumatoid Arthritis—A Narrative Review |
| title_fullStr | DNA and RNA Methylation in Rheumatoid Arthritis—A Narrative Review |
| title_full_unstemmed | DNA and RNA Methylation in Rheumatoid Arthritis—A Narrative Review |
| title_short | DNA and RNA Methylation in Rheumatoid Arthritis—A Narrative Review |
| title_sort | dna and rna methylation in rheumatoid arthritis a narrative review |
| topic | rheumatoid arthritis epigenetics DNA methylation RNA methylation |
| url | https://www.mdpi.com/2075-4655/9/1/2 |
| work_keys_str_mv | AT kajetankiełbowski dnaandrnamethylationinrheumatoidarthritisanarrativereview AT esterabakinowska dnaandrnamethylationinrheumatoidarthritisanarrativereview AT annagoracyrosik dnaandrnamethylationinrheumatoidarthritisanarrativereview AT karolinafigiel dnaandrnamethylationinrheumatoidarthritisanarrativereview AT roksanajudek dnaandrnamethylationinrheumatoidarthritisanarrativereview AT jakubrosik dnaandrnamethylationinrheumatoidarthritisanarrativereview AT pawełdec dnaandrnamethylationinrheumatoidarthritisanarrativereview AT andrzejmodrzejewski dnaandrnamethylationinrheumatoidarthritisanarrativereview AT andrzejpawlik dnaandrnamethylationinrheumatoidarthritisanarrativereview |