The influence of subventricular zone involvement in extent of resection and tumor growth pattern of glioblastoma

Isocitrate dehydrogenase (IDH1/2) mutations and O6-alkylguanine DNA methyltransferase (MGMT) promoter methylations are acknowledged survival predictors in patients with glioblastoma (GB). Moreover, tumor growth patterns like multifocality and subventricular zone (SVZ) involvement seem to be associat...

وصف كامل

التفاصيل البيبلوغرافية
الحاوية / القاعدة:Innovative Surgical Sciences
المؤلفون الرئيسيون: Ahmadipour Yahya, Krings Julie-Inga, Rauschenbach Laurèl, Gembruch Oliver, Chihi Mehdi, Darkwah Oppong Marvin, Pierscianek Daniela, Jabbarli Ramazan, Sure Ulrich, El Hindy Nicolai
التنسيق: مقال
اللغة:الإنجليزية
منشور في: De Gruyter 2020-08-01
الموضوعات:
extent of resection
glioblastoma
multifocality
subventricular zone
الوصول للمادة أونلاين:https://doi.org/10.1515/iss-2020-0011
الوصف
الملخص:Isocitrate dehydrogenase (IDH1/2) mutations and O6-alkylguanine DNA methyltransferase (MGMT) promoter methylations are acknowledged survival predictors in patients with glioblastoma (GB). Moreover, tumor growth patterns like multifocality and subventricular zone (SVZ) involvement seem to be associated with poorer outcomes. Here, we wanted to evaluate the influence of the SVZ involvement and the multifocal tumor growth on the extent of surgical resection and its correlation with overall survival (OS) and molecular characteristics of patients with GB.
تدمد:2364-7485

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