KLRG1 expression identifies short-lived Foxp3+ Treg effector cells with functional plasticity in islets of NOD mice

A progressive waning in Foxp3+ regulatory T (Treg) cell function provokes autoimmunity in the non-obese diabetic (NOD) mouse model of type 1 diabetes (T1D), a cellular defect rescued by prophylactic IL-2 therapy. We showed that most islet-infiltrating Treg cells express inducible T-cell co-stimulato...

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Bibliographic Details
Published in:	Autoimmunity
Main Authors:	Mara Kornete, Edward Mason, Roman Istomine, Ciriaco A. Piccirillo
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2017-08-01
Subjects:	foxp3+ treg cells icos fatigued t cells type 1 diabetes
Online Access:	http://dx.doi.org/10.1080/08916934.2017.1364368

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