REACTIVITY OF BLOOD LYMPHOCYTES IN PULMONARY TUBERCULOSIS

• Published in: Медицинская иммунология
• Main Authors: R. R. Khasanova, O. V. Voronkova, O. I. Urazova, V. V. Novitsky, A. K. Strelis, Yu. V. Stambula, A. E. Kolosova, V. A. Serebryakova, I. O. Naslednikova, O. V. Kolokolova, T. E. Budkina, N. P. Pirogova
• Format: Article
• Language: Russian
• Published: St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists 2014-07-01
• Subjects: pumonary tuberculosis; antigens; lymphocytes; cytokines; reactivity
• Online Access: https://www.mimmun.ru/mimmun/article/view/73
• ISSN: 1563-0625; 2313-741X

Evaluation of proliferative and IL-2-producing activity of peripheral blood lymphocytes wasperformed, using cultural methods, in patients with drug-sensitive and drug-resistant infiltrative pulmonary tuberculosis. The cell testing was performed at basal level and following in vitro stimulation with recombinant IL-2 and M. tuberculosis antigens. It was established that clinical course of infiltrative pulmonary tuberculosis, independently on drug sensitivity/resistance of the infectious pathogen, is accompanied by suppression of spontaneous lymphoproliferation. The levels of induced IL-2 production in drug-sensitive tuberculosis proved to be increased, whereas a reserve of IL-2-secreting reactivity of blood lymphocytes was lower than in drugresistant infection. Also, it was revealed that the level of lymphoproliferative response induced by IL-2, does not depend on clinical variant of tuberculosis, whereas stimulation of IL-2 production in blood lymphocytes is attained only in cases of drug-resistant tuberculosis variant.