“Better Late Than Never”—Late‐Onset Genotype‐Negative Congenital Long QT Syndrome: Case Report and Review
ABSTRACT Congenital long QT syndrome (LQTS) is a genetic disorder causing prolonged QT intervals and an increased risk of arrhythmias and sudden cardiac death. With 25% of cases lacking known genetic mutations, diagnosis and treatment can be challenging. We present a successfully managed case of lat...
| Published in: | Clinical Case Reports |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-02-01
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| Subjects: | |
| Online Access: | https://doi.org/10.1002/ccr3.70201 |
| _version_ | 1849675283725025280 |
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| author | Clement Tan Vaikunthan Thanabalasingam Chaminda Sella Kapu Zhihua Zhang |
| author_facet | Clement Tan Vaikunthan Thanabalasingam Chaminda Sella Kapu Zhihua Zhang |
| author_sort | Clement Tan |
| collection | DOAJ |
| container_title | Clinical Case Reports |
| description | ABSTRACT Congenital long QT syndrome (LQTS) is a genetic disorder causing prolonged QT intervals and an increased risk of arrhythmias and sudden cardiac death. With 25% of cases lacking known genetic mutations, diagnosis and treatment can be challenging. We present a successfully managed case of late‐onset genotype‐negative phenotype‐positive LQTS presenting as palpitations, complicated by a single event of polymorphic ventricular tachycardia, followed by a review of the literature. This case underscores the gaps in understanding congenital long QT syndrome, especially in genotype‐negative cases, and highlights the need for ongoing research for risk assessment and effective management to prevent fatal cardiac events. |
| format | Article |
| id | doaj-art-103f0b0dd21d4e0e9d75b4e23ddc2dca |
| institution | Directory of Open Access Journals |
| issn | 2050-0904 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Wiley |
| record_format | Article |
| spelling | doaj-art-103f0b0dd21d4e0e9d75b4e23ddc2dca2025-08-20T02:15:51ZengWileyClinical Case Reports2050-09042025-02-01132n/an/a10.1002/ccr3.70201“Better Late Than Never”—Late‐Onset Genotype‐Negative Congenital Long QT Syndrome: Case Report and ReviewClement Tan0Vaikunthan Thanabalasingam1Chaminda Sella Kapu2Zhihua Zhang3Department of Cardiology, Coronary Care Unit & Cardiac Catheterisation Laboratory Mackay Base Hospital Mackay Queensland AustraliaDepartment of Cardiology, Coronary Care Unit & Cardiac Catheterisation Laboratory Mackay Base Hospital Mackay Queensland AustraliaDepartment of Cardiology, Coronary Care Unit & Cardiac Catheterisation Laboratory Mackay Base Hospital Mackay Queensland AustraliaDepartment of Cardiology, Coronary Care Unit & Cardiac Catheterisation Laboratory Mackay Base Hospital Mackay Queensland AustraliaABSTRACT Congenital long QT syndrome (LQTS) is a genetic disorder causing prolonged QT intervals and an increased risk of arrhythmias and sudden cardiac death. With 25% of cases lacking known genetic mutations, diagnosis and treatment can be challenging. We present a successfully managed case of late‐onset genotype‐negative phenotype‐positive LQTS presenting as palpitations, complicated by a single event of polymorphic ventricular tachycardia, followed by a review of the literature. This case underscores the gaps in understanding congenital long QT syndrome, especially in genotype‐negative cases, and highlights the need for ongoing research for risk assessment and effective management to prevent fatal cardiac events.https://doi.org/10.1002/ccr3.70201congenitalgenotypegenotype negativeimplanted cardiac defibrillatorlate onsetlong QT syndrome |
| spellingShingle | Clement Tan Vaikunthan Thanabalasingam Chaminda Sella Kapu Zhihua Zhang “Better Late Than Never”—Late‐Onset Genotype‐Negative Congenital Long QT Syndrome: Case Report and Review congenital genotype genotype negative implanted cardiac defibrillator late onset long QT syndrome |
| title | “Better Late Than Never”—Late‐Onset Genotype‐Negative Congenital Long QT Syndrome: Case Report and Review |
| title_full | “Better Late Than Never”—Late‐Onset Genotype‐Negative Congenital Long QT Syndrome: Case Report and Review |
| title_fullStr | “Better Late Than Never”—Late‐Onset Genotype‐Negative Congenital Long QT Syndrome: Case Report and Review |
| title_full_unstemmed | “Better Late Than Never”—Late‐Onset Genotype‐Negative Congenital Long QT Syndrome: Case Report and Review |
| title_short | “Better Late Than Never”—Late‐Onset Genotype‐Negative Congenital Long QT Syndrome: Case Report and Review |
| title_sort | better late than never late onset genotype negative congenital long qt syndrome case report and review |
| topic | congenital genotype genotype negative implanted cardiac defibrillator late onset long QT syndrome |
| url | https://doi.org/10.1002/ccr3.70201 |
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