A mouse model of brittle cornea syndrome caused by mutation in Zfp469

Brittle cornea syndrome (BCS) is a rare recessive condition characterised by extreme thinning of the cornea and sclera. BCS results from loss-of-function mutations in the poorly understood genes ZNF469 or PRDM5. In order to determine the function of ZNF469 and to elucidate pathogenic mechanisms, we...

وصف كامل

التفاصيل البيبلوغرافية
الحاوية / القاعدة:	Disease Models & Mechanisms
المؤلفون الرئيسيون:	Chloe M. Stanton, Amy S. Findlay, Camilla Drake, Mohammad Z. Mustafa, Philippe Gautier, Lisa McKie, Ian J. Jackson, Veronique Vitart
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	The Company of Biologists 2021-09-01
الموضوعات:	brittle cornea keratocyte zfp469 znf469 collagen
الوصول للمادة أونلاين:	http://dmm.biologists.org/content/14/9/dmm049175

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