Delivering synaptic protein mRNAs via extracellular vesicles ameliorates cognitive impairment in a mouse model of Alzheimer’s disease

Abstract Background Synaptic dysfunction with reduced synaptic protein levels is a core feature of Alzheimer’s disease (AD). Synaptic proteins play a central role in memory processing, learning, and AD pathogenesis. Evidence suggests that synaptic proteins in plasma neuronal-derived extracellular ve...

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Bibliographic Details

Published in:	BMC Medicine
Main Authors:	Huimin Cai, Yana Pang, Ziye Ren, Xiaofeng Fu, Longfei Jia
Format:	Article
Language:	English
Published:	BMC 2024-03-01
Subjects:	Alzheimer’s disease Synaptic dysfunction Growth-associated protein 43 Synaptosome-associated protein 25 Extracellular vesicles Messenger RNAs
Online Access:	https://doi.org/10.1186/s12916-024-03359-2