In Vitro Response of Dental Stem Cells on Decellularized Extracellular Matrix-Derived Hydrogels
Periodontitis is an infectious inflammatory disease that damages the tissues supporting the tooth. Hydrogels are suitable candidates for periodontal regeneration due to their capacity to interact with soft and hard tissues and to conform to the 3D defect through minimal invasion procedures. Cell-der...
| Published in: | Engineering Proceedings |
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| Main Authors: | , , |
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-12-01
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| Subjects: | |
| Online Access: | https://www.mdpi.com/2673-4591/31/1/38 |
| Summary: | Periodontitis is an infectious inflammatory disease that damages the tissues supporting the tooth. Hydrogels are suitable candidates for periodontal regeneration due to their capacity to interact with soft and hard tissues and to conform to the 3D defect through minimal invasion procedures. Cell-derived decellularized extracellular matrix (dECM) can recreate cellular niches and model cellular function. In this work, collagen hydrogels were developed by incorporating lyophilized cell-derived dECM and their effects on the proliferation and osteogenic differentiation of dental stem cells were evaluated. Overall, our results confirmed the beneficial effect of dECM-derived hydrogels in proliferation and osteogenic differentiation of dental stem cells. |
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| ISSN: | 2673-4591 |