Similar neuronal imprint and no cross-seeded fibrils in α-synuclein aggregates from MSA and Parkinson’s disease

Abstract Aggregated alpha-synuclein (α-syn) is a principal constituent of Lewy bodies (LBs) and glial cytoplasmic inclusions (GCIs) observed respectively inside neurons in Parkinson’s disease (PD) and oligodendrocytes in multiple system atrophy (MSA). Yet, the cellular origin, the pathophysiological...

Full description

Bibliographic Details
Published in:	npj Parkinson's Disease
Main Authors:	Florent Laferrière, Stéphane Claverol, Erwan Bezard, Francesca De Giorgi, François Ichas
Format:	Article
Language:	English
Published:	Nature Portfolio 2022-01-01
Online Access:	https://doi.org/10.1038/s41531-021-00264-w

Similar Items

Biases in α-synuclein immuno-quantitation: a core problem for basic and ancillary studies of Parkinson’s disease and multiple system atrophy
by: Florent Laferrière, et al.
Published: (2024-03-01)

Overexpression of α-Synuclein by Oligodendrocytes in Transgenic Mice Does Not Recapitulate the Fibrillar Aggregation Seen in Multiple System Atrophy
by: Florent Laferrière, et al.
Published: (2020-10-01)

Neurons with Cat’s Eyes: A Synthetic Strain of α-Synuclein Fibrils Seeding Neuronal Intranuclear Inclusions
by: Francesca De Giorgi, et al.
Published: (2022-03-01)

α-Synuclein Fibrils as Penrose Machines: A Chameleon in the Gear
by: Francesca De Giorgi, et al.
Published: (2022-03-01)

Oligodendrocytes Prune Axons Containing α-Synuclein Aggregates In Vivo: Lewy Neurites as Precursors of Glial Cytoplasmic Inclusions in Multiple System Atrophy?
by: Francesco De Nuccio, et al.
Published: (2023-02-01)

Lewy-MSA hybrid fold drives distinct neuronal α-synuclein pathology
by: Masahiro Enomoto, et al.
Published: (2025-06-01)

A Novel C-Type Lectin Receptor-Targeted α-Synuclein-Based Parkinson Vaccine Induces Potent Immune Responses and Therapeutic Efficacy in Mice
by: Sabine Schmidhuber, et al.
Published: (2022-08-01)

Modelling α-Synuclein Aggregation and Neurodegeneration with Fibril Seeds in Primary Cultures of Mouse Dopaminergic Neurons
by: Aurore Tourville, et al.
Published: (2022-05-01)

Mechanisms of enhanced aggregation and fibril formation of Parkinson’s disease-related variants of α-synuclein
by: Takashi Ohgita, et al.
Published: (2022-04-01)

Alpha-Synuclein Aggregation in Parkinson's Disease
by: E. Srinivasan, et al.
Published: (2021-10-01)

α-synuclein fibrils per se but not α-synuclein seeded aggregation causes mitochondrial dysfunction and cell death in human neurons
by: Plamena R. Angelova, et al.
Published: (2025-10-01)

Optogenetic induction of alpha-synuclein aggregation in human dopaminergic neurons to model Parkinson’s disease pathology
by: Eun A. Ra, et al.
Published: (2023-12-01)

Limited effects of dysfunctional macroautophagy on the accumulation of extracellularly derived α-synuclein in oligodendroglia: implications for MSA pathogenesis
by: Lisa Fellner, et al.
Published: (2018-05-01)

Motor cortical neuronal hyperexcitability associated with α-synuclein aggregation
by: Liqiang Chen, et al.
Published: (2025-01-01)

Neuronal Oxidative Stress Promotes α-Synuclein Aggregation In Vivo
by: Seok Joon Won, et al.
Published: (2022-12-01)

A Surface Imprinted Polymer EIS Sensor for Detecting Alpha-Synuclein, a Parkinson’s Disease Biomarker
by: Roslyn Simone Massey, et al.
Published: (2024-02-01)

Aggregation and Propagation of α‐Synuclein in Parkinson's Disease: A Bibliometric Perspective
by: Xinyue Zhang, et al.
Published: (2025-11-01)

Radiological markers of CSF α-synuclein aggregation in Parkinson’s disease patients
by: Amgad Droby, et al.
Published: (2025-01-01)

Aggregation-resistant alpha-synuclein tetramers are reduced in the blood of Parkinson’s patients
by: Laura de Boni, et al.
Published: (2024-06-01)

GALECTIN-3 SHAPES TOXIC ALPHA-SYNUCLEIN AGGREGATES IN PARKINSON´S DISEASE
by: Juan Garcia-Revilla, et al.
Published: (2023-10-01)

Targeted degradation of ⍺-synuclein aggregates in Parkinson’s disease using the AUTOTAC technology
by: Jihoon Lee, et al.
Published: (2023-06-01)

Small soluble α-synuclein aggregates are the toxic species in Parkinson’s disease
by: Derya Emin, et al.
Published: (2022-09-01)

Physicochemical mechanisms of aggregation and fibril formation of α-synuclein and apolipoprotein A-I
by: Takashi Ohgita, et al.
Published: (2024-01-01)

Lysophosphatidylcholine promoting α-Synuclein aggregation in Parkinson’s disease: disrupting GCase glycosylation and lysosomal α-Synuclein degradation
by: Chunyan Mu, et al.
Published: (2025-03-01)

Genetic Diversity of <i>Babesia bovis</i> MSA-1, MSA-2b and MSA-2c in China
by: Jinming Wang, et al.
Published: (2020-06-01)

Alpha-Synuclein Preformed Fibrils Induce Cellular Senescence in Parkinson’s Disease Models
by: Dinesh Kumar Verma, et al.
Published: (2021-07-01)

Viral mediated α-synuclein overexpression results in greater transgene levels and α-synuclein overload in mice bearing kinase dead mutation of LRRK2
by: Federica Albanese, et al.
Published: (2025-03-01)

A novel approach to detecting plasma synuclein aggregates for Parkinson’s disease diagnosis
by: Hyo Rim Ko, et al.
Published: (2025-07-01)

EGFR phosphorylates DNAJB1 to suppress α-synuclein aggregation in Parkinson’s disease
by: Yun-Yu Huang, et al.
Published: (2025-06-01)

Blood Plasma of Patients with Parkinson’s Disease Increases Alpha-Synuclein Aggregation and Neurotoxicity
by: Peng Wang, et al.
Published: (2016-01-01)

Age-dependent alpha-synuclein aggregation and Lewy body formation in Parkinson’s disease
by: Chun Chau Sung, et al.
Published: (2025-12-01)

Dynamics of a model for the degradation mechanism of aggregated α-synuclein in Parkinson's disease
by: Bojie Yang, et al.
Published: (2023-04-01)

Correction: Targeted degradation of ⍺-synuclein aggregates in Parkinson’s disease using the AUTOTAC technology
by: Jihoon Lee, et al.
Published: (2023-09-01)

The role of alpha-synuclein oligomerization and aggregation in cellular and animal models of Parkinson's disease.
by: Oi Wan Wan, et al.
Published: (2012-01-01)

Plant Extracts and Phytochemicals Targeting α-Synuclein Aggregation in Parkinson's Disease Models
by: Hayate Javed, et al.
Published: (2019-03-01)

A qualitative analysis of a model on alpha-synuclein transport and aggregation in neurons
by: Salma Al-Tuwairqi, et al.
Published: (2023-06-01)

Impact of α-synuclein fibril structure on seeding activity in experimental models of Parkinson’s disease
by: Junichiro Ohira, et al.
Published: (2025-07-01)

Neuropathological stages of neuronal, astrocytic and oligodendrocytic alpha-synuclein pathology in Parkinson’s disease
by: Maria Otero-Jimenez, et al.
Published: (2025-02-01)

TFE3-mediated neuroprotection: Clearance of aggregated α-synuclein and accumulated mitochondria in the AAV-α-synuclein model of Parkinson's disease
by: Xin He, et al.
Published: (2025-03-01)

A novel approach to Parkinson’s disease treatment with a potentially dual-acting therapeutic agent that targets α-synuclein aggregation and neuron death
by: Allison R Balaj, et al.
Published: (2024-01-01)