| Summary: | The aim of this research is to determine protective effects of higenamine on kidney tissue injury caused by ischemia reperfusion. In this
study, 24 Sprague Dawley female rats were divided into 3 groups. The groups were designed as follows; control, ischemia reperfusion, and
ischemia reperfusion + higenamine. Some oxidant, antioxidant and inflammatory parameters were evaluated in kidney tissues at the end
of the experimental procedure. It was confirmed that the oxidant and inflammatory parameters of kidney tissue increased and antioxidant
parameters decreased in ischemia reperfusion group compared to control group. Antioxidant parameters increased while oxidant and
inflammatory parameters decreased in the ischemia reperfusion + higenamine group compared to ischemia reperfusion group. These results
have demonstrated that higenamine administration as single dose is effective against oxidative kidney damage originating from ischemia
reperfusion.
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