Integration of DOTA as a bridging unit during solid-phase peptide synthesis

A method for the introduction of bifunctionalized 1,4,7,10-tetraazacyclododecane-N,N’,N’’,N’’’-tetraacetic acid (DOTA) into the bridging unit of peptide-based radiopharmaceuticals has been developed. The method is executed in the context of Fmoc-based solid-phase peptide synthesis (SPPS) using stand...

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Bibliographic Details
Published in:	Results in Chemistry
Main Authors:	Lennard Wendlinger, Mara Parzinger, Margret Schottelius, Hans-Jürgen Wester
Format:	Article
Language:	English
Published:	Elsevier 2023-12-01
Subjects:	Chelator Bridging Unit Radiopharmaceuticals Solid-Phase Peptide Synthesis Radiohybrid Tracers
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211715623003156

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