Effectiveness of Laboratory Parameters as Morbidity and Mortality Indicators in Patients with Coronavirus Disease-2019 Admitted to the Intensive Care Unit

• Published in: Türk Yoğun Bakim Derneği Dergisi
• Main Authors: Leyla Kazancıoğlu, Başar Erdivanlı, Hızır Kazdal, Abdullah Özdemir, Tolga Koyuncu, Ayşe Hızal, Asiye Özdemir, İlkay Bahçeci, Şule Batcık, Tahir Ersöz
• Format: Article
• Language: English
• Published: Turkish Society of Intensive Care 2021-12-01
• Subjects: covid-19; pneumonia; intensive care unit; morbidity; mortality; geriatrics
• Online Access: http://www.turkishjic.org/archives/archive-detail/article-preview/effectiveness-of-laboratory-parameters-as-morbidit/47543
• ISSN: 2146-6416; 2147-267X

Objective:Laboratory parameters may predict the severity and mortality of coronavirus disease-2019 (COVID-19). We investigated the relationship of laboratory findings obtained at admission and 72nd hour and mortality and morbidity of patients with pneumonia who were treated in two intensive care units.Materials and Methods:Chart data of 75 patients (March-May 2020) were retrospectively analysed. Patient characteristics and laboratory parameters were compared according to the presence of COVID-19 and mortality. Patients with COVID-19 were compared according to mortality and gender.Results:The mean patient age was 74.7±11.3 years. COVID-19 positivity was not associated with marked differences in laboratory values. Lung disease, bedridden status, worse renal function scores, and high C-reactive protein level was more often observed in non-survivors (p<0.05). A decline in D-dimer level was more apparent in survivors; the increase in ferritin and neutrophillymphocyte ratio was more apparent in non-survivors (not significant). Among patients with COVID- 19, women had higher mean platelet volume than men (p=0.033). The rise in ferritin level was more pronounced in men, whereas the rise in neutrophil-lymphocyte ratio and platelet-lymphocyte ratio was higher in women.Conclusion:In this geriatric cohort, chronic lung disease and bedridden status were the main determinants of mortality. Moreover, different patterns of inflammatory markers may help predict the severity of COVID-19.