Neuropathological stages of neuronal, astrocytic and oligodendrocytic alpha-synuclein pathology in Parkinson’s disease

Abstract Alpha-synucleinopathies are neurodegenerative diseases characterized by the spread of alpha-synuclein (α-syn) aggregates throughout the central nervous system in a stereotypical manner. These diseases include Lewy body disease (LBD), which encompass Dementia with Lewy bodies (DLB), Parkinso...

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Bibliographic Details
Published in:	Acta Neuropathologica Communications
Main Authors:	Maria Otero-Jimenez, Marcelina J. Wojewska, Lawrence P. Binding, Simona Jogaudaite, Sandra Gray-Rodriguez, Alexandra L. Young, Steve Gentleman, Javier Alegre-Abarrategui
Format:	Article
Language:	English
Published:	BMC 2025-02-01
Subjects:	Alpha-synuclein Alpha-synucleinopathies Parkinson’s disease Astrocytes Neuroanatomical distribution Staging
Online Access:	https://doi.org/10.1186/s40478-025-01944-x

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