Next-generation sequencing reveals novel mutations in a collision tumor of glioblastoma and meningioma
Primary intracranial collision tumors are rare in patients without predisposing factors. We report such a case in a 42-year-old female who presented with headaches and altered mental status. Imaging revealed a single heterogeneous, rim-enhancing lesion in the left parieto-occipital periventricular r...
| Published in: | CNS Oncology |
|---|---|
| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2021-06-01
|
| Subjects: | |
| Online Access: | https://www.futuremedicine.com/doi/10.2217/cns-2020-0029 |
| _version_ | 1849579981699547136 |
|---|---|
| author | Kelly Chamberlin Gregory Chamberlin Katherine Saunders Simon Khagi |
| author_facet | Kelly Chamberlin Gregory Chamberlin Katherine Saunders Simon Khagi |
| author_sort | Kelly Chamberlin |
| collection | DOAJ |
| container_title | CNS Oncology |
| description | Primary intracranial collision tumors are rare in patients without predisposing factors. We report such a case in a 42-year-old female who presented with headaches and altered mental status. Imaging revealed a single heterogeneous, rim-enhancing lesion in the left parieto-occipital periventricular region, involving the corpus callosum. Stereotactic biopsy demonstrated glioblastoma. Subsequent tumor resection showed histologic evidence of glioblastoma and meningioma. Next-generation sequencing was performed on both tumor components. The glioblastoma exhibited a CDKN2A homozygous deletion and novel missense mutations in TAF1L and CSMD3, while no definitive genetic alterations were identified in the meningioma. Next-generation sequencing may yield insight into molecular drivers of intracranial collision tumors and aid in identifying future therapeutic targets. |
| format | Article |
| id | doaj-art-18cc9984fb7b476c8d82a4f2db2437e3 |
| institution | Directory of Open Access Journals |
| issn | 2045-0907 2045-0915 |
| language | English |
| publishDate | 2021-06-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| spelling | doaj-art-18cc9984fb7b476c8d82a4f2db2437e32025-08-20T02:26:02ZengTaylor & Francis GroupCNS Oncology2045-09072045-09152021-06-0110210.2217/cns-2020-0029Next-generation sequencing reveals novel mutations in a collision tumor of glioblastoma and meningiomaKelly Chamberlin0Gregory Chamberlin1Katherine Saunders2Simon Khagi31Department of Neurosurgery, UNC Hospitals, Chapel Hill, NC 27514, USA2Department of Pathology & Laboratory Medicine, UNC Hospitals, Chapel Hill, NC 27514, USA2Department of Pathology & Laboratory Medicine, UNC Hospitals, Chapel Hill, NC 27514, USA1Department of Neurosurgery, UNC Hospitals, Chapel Hill, NC 27514, USAPrimary intracranial collision tumors are rare in patients without predisposing factors. We report such a case in a 42-year-old female who presented with headaches and altered mental status. Imaging revealed a single heterogeneous, rim-enhancing lesion in the left parieto-occipital periventricular region, involving the corpus callosum. Stereotactic biopsy demonstrated glioblastoma. Subsequent tumor resection showed histologic evidence of glioblastoma and meningioma. Next-generation sequencing was performed on both tumor components. The glioblastoma exhibited a CDKN2A homozygous deletion and novel missense mutations in TAF1L and CSMD3, while no definitive genetic alterations were identified in the meningioma. Next-generation sequencing may yield insight into molecular drivers of intracranial collision tumors and aid in identifying future therapeutic targets.https://www.futuremedicine.com/doi/10.2217/cns-2020-0029collision tumorCSMD3glioblastomameningiomanext-generation sequencingTAF1L |
| spellingShingle | Kelly Chamberlin Gregory Chamberlin Katherine Saunders Simon Khagi Next-generation sequencing reveals novel mutations in a collision tumor of glioblastoma and meningioma collision tumor CSMD3 glioblastoma meningioma next-generation sequencing TAF1L |
| title | Next-generation sequencing reveals novel mutations in a collision tumor of glioblastoma and meningioma |
| title_full | Next-generation sequencing reveals novel mutations in a collision tumor of glioblastoma and meningioma |
| title_fullStr | Next-generation sequencing reveals novel mutations in a collision tumor of glioblastoma and meningioma |
| title_full_unstemmed | Next-generation sequencing reveals novel mutations in a collision tumor of glioblastoma and meningioma |
| title_short | Next-generation sequencing reveals novel mutations in a collision tumor of glioblastoma and meningioma |
| title_sort | next generation sequencing reveals novel mutations in a collision tumor of glioblastoma and meningioma |
| topic | collision tumor CSMD3 glioblastoma meningioma next-generation sequencing TAF1L |
| url | https://www.futuremedicine.com/doi/10.2217/cns-2020-0029 |
| work_keys_str_mv | AT kellychamberlin nextgenerationsequencingrevealsnovelmutationsinacollisiontumorofglioblastomaandmeningioma AT gregorychamberlin nextgenerationsequencingrevealsnovelmutationsinacollisiontumorofglioblastomaandmeningioma AT katherinesaunders nextgenerationsequencingrevealsnovelmutationsinacollisiontumorofglioblastomaandmeningioma AT simonkhagi nextgenerationsequencingrevealsnovelmutationsinacollisiontumorofglioblastomaandmeningioma |