Erythema multiforme secondary to filgrastim in a case of pemphigus vulgaris

Erythema multiforme (EM) is an acute inflammatory mucocutaneous disorder which can be triggered by host of factors including drugs. Filgrastim is a Granulocyte Colony-Stimulating Factor (G-CSF) analogue used to stimulate the production of white blood cells in patients on immunosuppressants developin...

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Bibliographic Details
Published in:Muller Journal of Medical Sciences and Research
Main Authors: Prachi Bhandare, Akshay Vishwanath Kadkol, M. Yashaswini, Pankaj Shukla
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2025-01-01
Subjects:
erythema multiforme
filgrastim
neutropenia
pemphigus vulgaris
rituximab
Online Access:https://journals.lww.com/10.4103/mjmsr.mjmsr_31_24
Description
Summary:Erythema multiforme (EM) is an acute inflammatory mucocutaneous disorder which can be triggered by host of factors including drugs. Filgrastim is a Granulocyte Colony-Stimulating Factor (G-CSF) analogue used to stimulate the production of white blood cells in patients on immunosuppressants developing neutropenia. EM following filgrastim usage is uncommonly reported in literature. The exact mechanism behind this reaction is not fully understood, but it is thought to be an immune-mediated response. Herein, we report this case of a 62-year-old male patient of active Pemphigus Vulgaris who developed EM following 2 doses of Filgrastim, which resolved after its discontinuation.
ISSN:0975-9727
2321-3701

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