Inhibition of platin-induced BCL2 increase overcomes chemoresistance in squamous cell carcinoma of the head and neck through resensitization to cell death

The clinical outcome of head and neck squamous cell carcinoma (HNSCC) remains poor with high recurrence rates, in part due to resistance to concurrent platinum-based chemotherapy. The anti-apoptotic BCL2 protein is involved in apoptosis resistance and tumor cell invasion/migration. Here, we test whe...

وصف كامل

التفاصيل البيبلوغرافية
الحاوية / القاعدة:Translational Oncology
المؤلفون الرئيسيون: Anne-Sophie Becker, Friederike Klauk, Thomas Freitag, Daniel Fabian Strüder, Björn Schneider, Annette Zimpfer, Claudia Maletzki
التنسيق: مقال
اللغة:الإنجليزية
منشور في: Elsevier 2025-03-01
الموضوعات:
Head and neck squamous cell carcinoma
BCL2
ABT-199
Cisplatin
Chemoresistance
Apoptosis
الوصول للمادة أونلاين:http://www.sciencedirect.com/science/article/pii/S1936523325000397

الانترنت

http://www.sciencedirect.com/science/article/pii/S1936523325000397

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