Cytotoxicity of Two Triterpenoids from Nigella glandulifera

During an investigation of antitumor substances from Nigella glandulifera Freyn et Sint. (Ranunculaceae) the cytotoxicity of two oleanane triterpene saponins isolated from the seeds of this species, kalopanaxsaponins A and I, was evaluated against HepG2, drug resistant HepG2 (R-HepG2) (two hepatocyt...

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Bibliographic Details
Published in:Molecules
Main Authors: Erxi Wu, Liao Wang, Pei-Gen Xiao, Jun-Shan Yang, Si-Bao Chen, Yu-Ming Liu, Ze Tian
Format: Article
Language:English
Published: MDPI AG 2006-09-01
Subjects:
Nigella glandulifera
oleanane type saponins
cytotoxicity
HepG2
apoptosis
Online Access:http://www.mdpi.com/1420-3049/11/9/693/
Description
Summary:During an investigation of antitumor substances from Nigella glandulifera Freyn et Sint. (Ranunculaceae) the cytotoxicity of two oleanane triterpene saponins isolated from the seeds of this species, kalopanaxsaponins A and I, was evaluated against HepG2, drug resistant HepG2 (R-HepG2) (two hepatocyte cell lines) and primary cultured normal mouse hepatocytes. Evident cytotoxic activities were observed. Morphological observations and cell cycle analysis suggest that these compounds inhibit the proliferation of hepatoma by inducing apoptosis and consequently kalopanaxsaponins A and I may be potential therapeutic agents for the treatment of parental and drug resistant hepatoma.
ISSN:1420-3049

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