Myelofibrosis at diagnosis is associated with the failure of treatment-free remission in CML patients

The management of patients with chronic myeloid leukemia (CML) has been revolutionized by the introduction of tyrosine kinase inhibitors (TKIs), which induce deep molecular responses so that treatment can eventually be discontinued, leading to treatment-free remission (TFR) in a subset of patients....

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Bibliographic Details
Published in:Frontiers in Pharmacology
Main Authors: Henrike Jacobi, Margherita Vieri, Marlena Bütow, Carolina Y. Namasu, Laura Flüter, Ivan G. Costa, Tiago Maié, Katharina Lindemann-Docter, Nicolas Chatain, Fabian Beier, Michael Huber, Wolfgang Wagner, Martina Crysandt, Tim H. Brümmendorf, Mirle Schemionek
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Subjects:
CML
TFR
fibrosis
leukemic stem cells
LSC
MSc
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1212392/full

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