Current Evidence on the Involvement of RAGE–Diaph1 Signaling in the Pathology and Treatment of Neurodegenerative Diseases—An Overview
Neurodegenerative diseases are a group of disorders characterized by the progressive deterioration of the structure and function of central nervous system neurons and include, among others, amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), Parkinson’s (PD), Alzheimer’s (AD), and Huntingt...
| الحاوية / القاعدة: | Pathophysiology |
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| المؤلفون الرئيسيون: | , , , , |
| التنسيق: | مقال |
| اللغة: | الإنجليزية |
| منشور في: |
MDPI AG
2025-08-01
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| الموضوعات: | |
| الوصول للمادة أونلاين: | https://www.mdpi.com/1873-149X/32/3/43 |
| _version_ | 1848775655012958208 |
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| author | Judyta K. Juranek Bernard Kordas Piotr Podlasz Agnieszka Bossowska Marta Banach |
| author_facet | Judyta K. Juranek Bernard Kordas Piotr Podlasz Agnieszka Bossowska Marta Banach |
| author_sort | Judyta K. Juranek |
| collection | DOAJ |
| container_title | Pathophysiology |
| description | Neurodegenerative diseases are a group of disorders characterized by the progressive deterioration of the structure and function of central nervous system neurons and include, among others, amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), Parkinson’s (PD), Alzheimer’s (AD), and Huntington’s (HD) diseases. And while all these diseases seem to have different genetic and environmental components, growing evidence shows that they share common underlying pathological features such as increased neuroinflammation and excessive oxidative stress. RAGE, the receptor for advanced glycation end-products, is a signal transduction receptor, and its activation triggers an increase in proinflammatory molecules, oxidative stressors, and cytokines. Diaph1, protein diaphanous homolog 1, is an actin modulator and an intracellular ligand of RAGE. Studies demonstrated that RAGE and Diaph1 act together, and their downstream signaling pathways play a role in neurodegeneration. Here, based on current evidence and our own research, we provide an overview of the RAGE–Diaph1 signaling and discuss the therapeutic potential of targeted therapy aimed at RAGE–Diaph1 signaling inhibition in the prevention and treatment of neurodegenerative diseases. |
| format | Article |
| id | doaj-art-1c1935851b5440ddae6cc01490fc7f3f |
| institution | Directory of Open Access Journals |
| issn | 1873-149X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| spelling | doaj-art-1c1935851b5440ddae6cc01490fc7f3f2025-09-26T15:06:41ZengMDPI AGPathophysiology1873-149X2025-08-013234310.3390/pathophysiology32030043Current Evidence on the Involvement of RAGE–Diaph1 Signaling in the Pathology and Treatment of Neurodegenerative Diseases—An OverviewJudyta K. Juranek0Bernard Kordas1Piotr Podlasz2Agnieszka Bossowska3Marta Banach4Department of Human Physiology and Pathophysiology, School of Medicine, University of Warmia and Mazury in Olsztyn, 11-041 Olsztyn, PolandDepartment of Human Physiology and Pathophysiology, School of Medicine, University of Warmia and Mazury in Olsztyn, 11-041 Olsztyn, PolandDepartment of Pathophysiology, Forensic Veterinary Medicine and Administration, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, 10-719 Olsztyn, PolandDepartment of Human Physiology and Pathophysiology, School of Medicine, University of Warmia and Mazury in Olsztyn, 11-041 Olsztyn, PolandDepartment of Neurology, Collegium Medicum, Jagiellonian University, 31-530 Kraków, PolandNeurodegenerative diseases are a group of disorders characterized by the progressive deterioration of the structure and function of central nervous system neurons and include, among others, amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), Parkinson’s (PD), Alzheimer’s (AD), and Huntington’s (HD) diseases. And while all these diseases seem to have different genetic and environmental components, growing evidence shows that they share common underlying pathological features such as increased neuroinflammation and excessive oxidative stress. RAGE, the receptor for advanced glycation end-products, is a signal transduction receptor, and its activation triggers an increase in proinflammatory molecules, oxidative stressors, and cytokines. Diaph1, protein diaphanous homolog 1, is an actin modulator and an intracellular ligand of RAGE. Studies demonstrated that RAGE and Diaph1 act together, and their downstream signaling pathways play a role in neurodegeneration. Here, based on current evidence and our own research, we provide an overview of the RAGE–Diaph1 signaling and discuss the therapeutic potential of targeted therapy aimed at RAGE–Diaph1 signaling inhibition in the prevention and treatment of neurodegenerative diseases.https://www.mdpi.com/1873-149X/32/3/43neurodegenerative diseasesreceptor for advanced glycation end-productsDiaph1pathogenesistreatmentsignaling |
| spellingShingle | Judyta K. Juranek Bernard Kordas Piotr Podlasz Agnieszka Bossowska Marta Banach Current Evidence on the Involvement of RAGE–Diaph1 Signaling in the Pathology and Treatment of Neurodegenerative Diseases—An Overview neurodegenerative diseases receptor for advanced glycation end-products Diaph1 pathogenesis treatment signaling |
| title | Current Evidence on the Involvement of RAGE–Diaph1 Signaling in the Pathology and Treatment of Neurodegenerative Diseases—An Overview |
| title_full | Current Evidence on the Involvement of RAGE–Diaph1 Signaling in the Pathology and Treatment of Neurodegenerative Diseases—An Overview |
| title_fullStr | Current Evidence on the Involvement of RAGE–Diaph1 Signaling in the Pathology and Treatment of Neurodegenerative Diseases—An Overview |
| title_full_unstemmed | Current Evidence on the Involvement of RAGE–Diaph1 Signaling in the Pathology and Treatment of Neurodegenerative Diseases—An Overview |
| title_short | Current Evidence on the Involvement of RAGE–Diaph1 Signaling in the Pathology and Treatment of Neurodegenerative Diseases—An Overview |
| title_sort | current evidence on the involvement of rage diaph1 signaling in the pathology and treatment of neurodegenerative diseases an overview |
| topic | neurodegenerative diseases receptor for advanced glycation end-products Diaph1 pathogenesis treatment signaling |
| url | https://www.mdpi.com/1873-149X/32/3/43 |
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