Mitochondrial–Endoplasmic Reticulum Interplay: A Lifelong On–Off Relationship?
This article comments recent publications that highlight an intriguing importance of specific settings in the interaction between the mitochondria and the endoplasmic reticulum to ensure cell-specific functions like the responsiveness to elevated glucose in pancreatic β-cells. Hence, alterations of...
| Published in: | Contact |
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| Main Authors: | , , |
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2019-07-01
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| Online Access: | https://doi.org/10.1177/2515256419861227 |
| Summary: | This article comments recent publications that highlight an intriguing importance of specific settings in the interaction between the mitochondria and the endoplasmic reticulum to ensure cell-specific functions like the responsiveness to elevated glucose in pancreatic β-cells. Hence, alterations of the mitochondria–endoplasmic reticulum communications under various pathological conditions like aging or cancer often come with enhanced Ca 2+ transfer that, in turn, yields stimulation of basal mitochondrial activity to meet the increasing adenosine triphosphate demand of the very cell. Such observations identify mitochondria-associated membranes as potential target for new therapeutic strategies against aging or cancer. |
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| ISSN: | 2515-2564 |