Huntingtin-associated protein 1 plays an essential role in the pathogenesis of type 2 diabetes by regulating the translocation of GLUT4 in mouse adipocytes

Objective Glucose disposal by insulin-responsive tissues maintains the body glucose homeostasis and insulin resistance leads to a risk of developing type 2 diabetes (T2DM). Insulin stimulates the translocation of glucose transporter isoform 4 (GLUT4) vesicles from intracellular compartments to the p...

Full description

Bibliographic Details
Published in:	BMJ Open Diabetes Research & Care
Main Authors:	Yan-Ju Gong, Ying Feng, Yuan-Yuan Cao, Jia Zhao, Ya-Yun Zheng, Jia-Rui Wu, Gui-Zhi Yang
Format:	Article
Language:	English
Published:	BMJ Publishing Group 2020-04-01
Online Access:	https://drc.bmj.com/content/8/1/e001199.full

Similar Items

Huntingtin plays an essential role in the adult hippocampus
by: Jessica C. Barron, et al.
Published: (2025-03-01)

LRRK2 negatively regulates glucose tolerance via regulation of membrane translocation of GLUT4 in adipocytes
by: Fumitaka Kawakami, et al.
Published: (2023-12-01)

Effect of Cholecalciferol on GLUT4 Expression in Adipocyte of Diabetic Rats
by: Dewi Ratna Sari, et al.
Published: (2015-11-01)

GLUT4 in Mouse Endometrial Epithelium: Roles in Embryonic Development and Implantation
by: Yun Long, et al.
Published: (2021-06-01)

GLUT4 traffic through an ESCRT-III-dependent sorting compartment in adipocytes.
by: Françoise Koumanov, et al.
Published: (2012-01-01)

The role of macrophage and adipocyte mitochondrial dysfunction in the pathogenesis of obesity
by: Min Wang, et al.
Published: (2024-11-01)

Observing GLUT4 Translocation in Live L6 Cells Using Quantum Dots
by: Feng Qu, et al.
Published: (2011-02-01)

A huntingtin peptide inhibits polyQ-huntingtin associated defects.
by: Yoan Arribat, et al.
Published: (2013-01-01)

Pleiotropic effects of mutant huntingtin on retinopathy in two mouse models of Huntington's disease
by: Hui Xu, et al.
Published: (2025-02-01)

Nuciferine relieves type 2 diabetes mellitus via enhancing GLUT4 expression and translocation
by: Tongxi Zhou, et al.
Published: (2023-11-01)

MicroRNAs-Mediated Regulation of Skeletal Muscle GLUT4 Expression and Translocation in Insulin Resistance
by: João Victor Esteves, et al.
Published: (2017-01-01)

The flavonoid luteolin reduces mutant huntingtin aggregation and cytotoxicity in huntingtin-mutated neuroblastoma cells
by: Azza Ramadan, et al.
Published: (2023-12-01)

Pharmacodynamic biomarkers responsive to mutant huntingtin lowering in a Huntington's disease mouse model
by: Deanna M. Marchionini, et al.
Published: (2025-06-01)

Reducing huntingtin by immunotherapy delays disease progression in a mouse model of Huntington disease
by: Stefan Bartl, et al.
Published: (2024-01-01)

Phosphorylation of the N-terminus of Syntaxin-16 controls interaction with mVps45 and GLUT4 trafficking in adipocytes
by: Shaun K. Bremner, et al.
Published: (2023-07-01)

Enhancement of Glucose Uptake by Meso-Dihydroguaiaretic Acid through GLUT4 Up-Regulation in 3T3-L1 Adipocytes
by: Anna Lee, et al.
Published: (2017-08-01)

HAP40 is a conserved central regulator of Huntingtin and a potential modulator of Huntington's disease pathogenesis.
by: Shiyu Xu, et al.
Published: (2022-07-01)

HAP40 is a conserved central regulator of Huntingtin and a potential modulator of Huntington’s disease pathogenesis
by: Shiyu Xu, et al.
Published: (2022-07-01)

N-terminal Huntingtin Knock-In Mice: Implications of Removing the N-terminal Region of Huntingtin for Therapy.
by: Xudong Liu, et al.
Published: (2016-05-01)

Quantifying mutant huntingtin protein in human cerebrospinal fluid to support the development of huntingtin-lowering therapies
by: Stephanie Vauleon, et al.
Published: (2023-04-01)

A pathogenic proteolysis–resistant huntingtin isoform induced by an antisense oligonucleotide maintains huntingtin function
by: Hyeongju Kim, et al.
Published: (2022-09-01)

An epigenome atlas of mouse adipocytes
by: Laura C. Hinte, et al.
Published: (2025-09-01)

Dysregulated GLUT1 results in the pathogenesis of preeclampsia by impairing the function of trophoblast cells
by: Jingyuan Pei, et al.
Published: (2024-10-01)

Levels of mutant huntingtin influence the phenotypic severity of Huntington disease in YAC128 mouse models
by: Rona K. Graham, et al.
Published: (2006-02-01)

Sortilin-mediated translocation of mitochondrial ACSL1 impairs adipocyte thermogenesis and energy expenditure in male mice
by: Min Yang, et al.
Published: (2024-09-01)

Physical exercise induces increased translocation of type 4 glucose transporters (GLUT4): a systematic review
by: Novadri Ayubi, et al.
Published: (2024-10-01)

<i>Gundelia tournefortii</i>: Fractionation, Chemical Composition and GLUT4 Translocation Enhancement in Muscle Cell Line
by: Sleman Kadan, et al.
Published: (2021-06-01)

Enterococcus faecalis Metabolizes Matairesinol to Enterolactone, Which Promotes E. faecalis Growth and Glut4-Dependent Glucose Uptake in Adipocytes
by: Emily Bayliss, et al.
Published: (2025-05-01)

Interleukin-6 Treatment Results in GLUT4 Translocation and AMPK Phosphorylation in Neuronal SH-SY5Y Cells
by: Daniel M. Marko, et al.
Published: (2020-04-01)

Insulin Sensitization by PPARγ and GLUT-4 Overexpression/Translocation Mediates the Antidiabetic Effect of <i>Plantago australis</i>
by: Samuel Estrada-Soto, et al.
Published: (2023-04-01)

Cacao liquor procyanidin extract improves glucose tolerance by enhancing GLUT4 translocation and glucose uptake in skeletal muscle
by: Yoko Yamashita, et al.
Published: (2012-04-01)

Jiangtang Sanhao formula ameliorates skeletal muscle insulin resistance via regulating GLUT4 translocation in diabetic mice
by: Zimengwei Ye, et al.
Published: (2022-09-01)

Benefits of global mutant huntingtin lowering diminish over time in a Huntington’s disease mouse model
by: Deanna M. Marchionini, et al.
Published: (2022-10-01)

Rhes depletion promotes striatal accumulation and aggregation of mutant huntingtin in a presymptomatic HD mouse model
by: Yongcheng Pan, et al.
Published: (2023-08-01)

Translocation of the Alphanucleorhabdovirus X proteins from the cytoplasm into the nucleus through interaction with nucleocapsid protein is essential for viral pathogenesis
by: Shuo Wang, et al.
Published: (2024-11-01)

Aberrant splicing of mutant huntingtin in Huntington's disease knock-in pigs
by: Huichun Tong, et al.
Published: (2023-10-01)

Glucose transporters GLUT1, GLUT3, and GLUT4 have different effects on osteoblast proliferation and metabolism
by: Milja Arponen, et al.
Published: (2022-11-01)

Characterisation of GLUT4 trafficking in HeLa cells: comparable kinetics and orthologous trafficking mechanisms to 3T3-L1 adipocytes
by: Silke Morris, et al.
Published: (2020-03-01)

CDK4 is an essential insulin effector in adipocytes
by: Sylviane Lagarrigue, et al.
Published: (2023-03-01)

Understanding The Mechanism of GLUT4 Translocation Involving Non-Conserved Complexes from A Modeling and Simulation T2DM Perspective
by: Ari Kusumastuti, et al.
Published: (2025-03-01)