Malignant Subcutaneous Perivascular Epithelioid Cell Tumor of Anterior Abdominal Wall

• Published in: Oman Medical Journal
• Main Authors: David Eng Yeow Gan, Rebecca Xin Yi Choy, Harivinthan Sellappan, Firdaus Hayati, Nornazirah Azizan4
• Format: Article
• Language: English
• Published: Oman Medical Specialty Board 2021-03-01
• Subjects: epithelioid cells; perivascular epithelioid cell neoplasms
• Online Access: http://omjournal.org/articleDetails.aspx?coType=1&aId=2871
• ISSN: 1999-768X; 2070-5204

Perivascular epithelioid cell tumors (PEComas) are a family of rare mesenchymal tumors with discrete histological and immunohistochemical characteristics. Even rarer among them are cutaneous and subcutaneous PEComas. We describe a 34-year-old woman who presented with a large anterior abdominal subcutaneous lesion showing intact overlying skin and no obvious invasion of the abdominal musculature. A wide local excision was performed. Histopathology revealed a solitary tumor measuring 75 × 55 × 90 mm with epithelioid cells in nests with thin fibrovascular septa and spindle cells. Resection margins were clear with no invasion to the skin or rectus sheath. Tumor cells were positive for HMB-45 but negative for other markers. This is the largest subcutaneous PEComa reported to date.