A conserved MCM single-stranded DNA binding element is essential for replication initiation

The ring-shaped MCM helicase is essential to all phases of DNA replication. The complex loads at replication origins as an inactive double-hexamer encircling duplex DNA. Helicase activation converts this species to two active single hexamers that encircle single-stranded DNA (ssDNA). The molecular d...

وصف كامل

التفاصيل البيبلوغرافية
الحاوية / القاعدة:	eLife
المؤلفون الرئيسيون:	Clifford A Froelich, Sukhyun Kang, Leslie B Epling, Stephen P Bell, Eric J Enemark
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	eLife Sciences Publications Ltd 2014-04-01
الموضوعات:	DNA replication helicase crystallography genetic archaea
الوصول للمادة أونلاين:	https://elifesciences.org/articles/01993

مواد مشابهة

Preparing to unwind
حسب: Jin Chuan Zhou, وآخرون
منشور في: (2014-04-01)

The haloarchaeal MCM proteins: bioinformatic analysis and targeted mutagenesis of the β7-β8 and β9-β10 hairpin loops and conserved zinc binding domain cysteines
حسب: Tatjana P Kristensen, وآخرون
منشور في: (2014-03-01)

Action of CMG with strand-specific DNA blocks supports an internal unwinding mode for the eukaryotic replicative helicase
حسب: Lance Langston, وآخرون
منشور في: (2017-03-01)

Inteins at Eleven Distinct Insertion Sites in Archaeal Helicase Subunit MCM Exhibit Varied Architectures and Activity Levels Across Archaeal Groups
حسب: Danielle Arsenault, وآخرون
منشور في: (2025-08-01)

A conserved Mcm4 motif is required for Mcm2-7 double-hexamer formation and origin DNA unwinding
حسب: Kanokwan Champasa, وآخرون
منشور في: (2019-08-01)

Viral hijacking of a replicative helicase loader and its implications for helicase loading control and phage replication
حسب: Iris V Hood, وآخرون
منشور في: (2016-05-01)

The replicative CMG helicase: the ideal target for cancer therapy
حسب: W. Henderson, وآخرون
منشور في: (2020-12-01)

Identification of 1600 replication origins in S. cerevisiae
حسب: Eric J Foss, وآخرون
منشور في: (2024-02-01)

Mechanisms of opening and closing of the bacterial replicative helicase
حسب: Jillian Chase, وآخرون
منشور في: (2018-12-01)

Nucleosomes influence multiple steps during replication initiation
حسب: Ishara F Azmi, وآخرون
منشور في: (2017-03-01)

A back-up mechanism for replication
حسب: Godefroid Charbon, وآخرون
منشور في: (2025-05-01)

Managing Single-Stranded DNA during Replication Stress in Fission Yeast
حسب: Sarah A. Sabatinos, وآخرون
منشور في: (2015-09-01)

Timeless–Tipin interactions with MCM and RPA mediate DNA replication stress response
حسب: Paulina Prorok, وآخرون
منشور في: (2024-02-01)

CMG helicase disassembly is controlled by replication fork DNA, replisome components and a ubiquitin threshold
حسب: Tom D Deegan, وآخرون
منشور في: (2020-08-01)

Primosomal protein PriC rescues replication initiation stress by bypassing the DnaA-DnaB interaction step for DnaB helicase loading at oriC
حسب: Ryusei Yoshida, وآخرون
منشور في: (2025-05-01)

Two opposite abilities of the infectious bronchitis virus helicase Nsp13: separating the duplex and promoting the annealing of single-stranded nucleic acid
حسب: Chengcheng Wu, وآخرون
منشور في: (2025-03-01)

An explanation for origin unwinding in eukaryotes
حسب: Lance D Langston, وآخرون
منشور في: (2019-07-01)

DNA Replication in Time and Space: The Archaeal Dimension
حسب: Anastasia Serdyuk, وآخرون
منشور في: (2025-05-01)

Oxysterol binding protein (OSBP) contributes to hepatitis E virus replication
حسب: Shaoli Lin, وآخرون
منشور في: (2024-07-01)

DNA Replication Origins in Microbial Genomes
حسب: Feng eGao
منشور في: (2016-01-01)

RNA Helicase A Regulates the Replication of RNA Viruses
حسب: Rui-Zhu Shi, وآخرون
منشور في: (2021-02-01)

Joint Efforts of Replicative Helicase and SSB Ensure Inherent Replicative Tolerance of G‐Quadruplex
حسب: Lijuan Guo, وآخرون
منشور في: (2024-03-01)

Methotrexate, an anti-inflammatory drug, inhibits Hepatitis E viral replication
حسب: Akash Kumar, وآخرون
منشور في: (2023-12-01)

Cdc6 ATPase activity disengages Cdc6 from the pre-replicative complex to promote DNA replication
حسب: FuJung Chang, وآخرون
منشور في: (2015-08-01)

S-CDK-regulated bipartite interaction of Mcm10 with MCM is essential for DNA replication
حسب: Xueting Wang, وآخرون
منشور في: (2024-09-01)

Archaeal DNA replication initiation: bridging LUCA's legacy and modern mechanisms
حسب: Rémi Dulermo
منشور في: (2025-02-01)

Phylogenetic Diversity of Lhr Proteins and Biochemical Activities of the Thermococcales aLhr2 DNA/RNA Helicase
حسب: Mirna Hajj, وآخرون
منشور في: (2021-06-01)

DDX21 Promotes PCV3 Replication by Binding to Cap Protein and Inhibiting Interferon Responses
حسب: Haoyu Sun, وآخرون
منشور في: (2025-01-01)

A Decade of Discovery—Eukaryotic Replisome Disassembly at Replication Termination
حسب: Rebecca M. Jones, وآخرون
منشور في: (2024-03-01)

Interaction and assembly of the DNA replication core proteins of Kaposi’s sarcoma-associated herpesvirus
حسب: Lee-Wen Chen, وآخرون
منشور في: (2023-12-01)

DNA Helicase–Polymerase Coupling in Bacteriophage DNA Replication
حسب: Chen-Yu Lo, وآخرون
منشور في: (2021-08-01)

RecQ helicases and genome stability: lessons from model organisms and human disease
حسب: L Bjergbaek, وآخرون
منشور في: (2002-08-01)

Interplay between chromosomal architecture and termination of DNA replication in bacteria
حسب: Daniel J. Goodall, وآخرون
منشور في: (2023-06-01)

Integrative analysis of DNA replication origins and ORC-/MCM-binding sites in human cells reveals a lack of overlap
حسب: Mengxue Tian, وآخرون
منشور في: (2024-04-01)

Antagonistic control of DDK binding to licensed replication origins by Mcm2 and Rad53
حسب: Syafiq Abd Wahab, وآخرون
منشور في: (2020-07-01)

Viral replication organelles: the highly complex and programmed replication machinery
حسب: Hao Deng, وآخرون
منشور في: (2024-07-01)

The Response of the Replication Apparatus to Leading Template Strand Blocks
حسب: Marina A. Bellani, وآخرون
منشور في: (2023-11-01)

Assembly, Activation, and Helicase Actions of MCM2-7: Transition from Inactive MCM2-7 Double Hexamers to Active Replication Forks
حسب: Zhiying You, وآخرون
منشور في: (2024-08-01)

The human Dicer helicase domain is capable of ATP hydrolysis and single-stranded nucleic acid binding
حسب: Kinga Ciechanowska, وآخرون
منشور في: (2024-12-01)

The helicase activity of hyperthermophilic archaeal MCM is enhanced at high temperatures by lysine methylation
حسب: Yisui eXia, وآخرون
منشور في: (2015-11-01)