Virulence-related regulatory network of Pseudomonas syringae

• Published in: Computational and Structural Biotechnology Journal
• Main Authors: Jiadai Huang, Chunyan Yao, Yue Sun, Quanjiang Ji, Xin Deng
• Format: Article
• Language: English
• Published: Elsevier 2022-01-01
• Subjects: Pseudomonas syringae; Transcription factors; Virulence; Regulatory networks
• Online Access: http://www.sciencedirect.com/science/article/pii/S2001037022005050

Transcription factors (TFs) play important roles in regulating multiple biological processes by binding to promoter regions and regulating the global gene transcription levels. Pseudomonas syringae is a Gram-negative phytopathogenic bacterium harbouring 301 putative TFs in its genome, approximately 50 of which are responsible for virulence-related gene and pathway regulation. Over the past decades, RNA sequencing, chromatin immunoprecipitation sequencing, high-throughput systematic evolution of ligands by exponential enrichment, and other technologies have been applied to identify the functions of master regulators and their interactions in virulence-related pathways. This review summarises the recent advances in the regulatory networks of TFs involved in the type III secretion system (T3SS) and non-T3SS virulence-associated pathways, including motility, biofilm formation, quorum sensing, nucleotide-based secondary messengers, phytotoxins, siderophore production, and oxidative stress. Moreover, this review discusses the future perspectives in terms of TF-mediated pathogenesis mechanisms and provides novel insights that will help combat P. syringae infections based on the regulatory networks of TFs.