Glycyrrhizin Interacts with TLR4 and TLR9 to Resolve <i>P. aeruginosa</i> Keratitis
This study tests the mechanism(s) of glycyrrhizin (GLY) protection against <i>P. aeruginosa</i> keratitis. Female C57BL/6 (B6), TLR4 knockout (TLR4KO), myeloid specific TLR4KO (mTLR4KO), their wildtype (WT) littermates, and TLR9 knockout (TLR9KO) mice were infected with <i>P. aerug...
| Published in: | Pathogens |
|---|---|
| Main Authors: | Mallika Somayajulu, Sharon A. McClellan, Shukkur Muhammed Farooq, Ahalya Pitchaikannu, Shunbin Xu, Linda Hazlett |
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-11-01
|
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-0817/11/11/1327 |
Similar Items
Single nucleotide polymorphisms of TLR-2, TLR-3, TLR-4 and susceptibility to inflammatory diseases of the respiratory tract
by: N. O. Pryimenko, et al.
Published: (2018-10-01)
by: N. O. Pryimenko, et al.
Published: (2018-10-01)
Single Nucleotide Variants in the TLR1, TLR2 and TLR6 Genes: A Case–Control Study in a Colombian Population
by: Luz D. Gutierrez-Castañeda, et al.
Published: (2023-10-01)
by: Luz D. Gutierrez-Castañeda, et al.
Published: (2023-10-01)
Paroxetine effect on expression of TLR2 and TLR4 genes in PBMCs of mentally normal individuals
by: Fatemeh Ganjalishahi, et al.
Published: (2021-08-01)
by: Fatemeh Ganjalishahi, et al.
Published: (2021-08-01)
The Relevance of TLR8 in Viral Infections
by: Iván Martínez-Espinoza, et al.
Published: (2022-01-01)
by: Iván Martínez-Espinoza, et al.
Published: (2022-01-01)
Effects of Glycyrrhizin on Multi-Drug Resistant <i>Pseudomonas aeruginosa</i>
by: Nicholas J. Carruthers, et al.
Published: (2020-09-01)
by: Nicholas J. Carruthers, et al.
Published: (2020-09-01)
Evaluation of the constitutive expression levels of ch-TLR 3, ch-TLR 4, ch-TLR 15 and ch-TLR 21 genes in the Peripheral Blood Mononuclear Cells of native Indian poultry breeds, Aseel and Kadaknath
by: H. C. Chauhan, et al.
Published: (2013-06-01)
by: H. C. Chauhan, et al.
Published: (2013-06-01)
Association of TLR7 and TLR9 genes polymorphisms in Egyptian patients with systemic lupus erythematosus
by: Marwa M. Azab, et al.
Published: (2022-11-01)
by: Marwa M. Azab, et al.
Published: (2022-11-01)
Synonymous mutations in TLR2 and TLR9 genes decrease COPD susceptibility in the Chinese Han population
by: X. Ding, et al.
Published: (2024-05-01)
by: X. Ding, et al.
Published: (2024-05-01)
RISK FOR PNEUMONIA AND TLR2 AND TLR4 GENE POLYMORPHISMS: A META-ANALYSIS
by: S. V. Smirnova, et al.
Published: (2016-01-01)
by: S. V. Smirnova, et al.
Published: (2016-01-01)
THE TLR4 299GLY POLYMORPHIC ALLELE IS ASSOCIATED WITH REDUCED EFFICACY OF AZITHROMYCIN AND PIOGLITAZONE, INCLUDED IN THE COMPREHENSIVE TREATMENT OF PATIENTS WITH CORONARY HEART DISEASE
by: O.V. Skochko
Published: (2017-11-01)
by: O.V. Skochko
Published: (2017-11-01)
The role of TLR-4 gene in the functioning of the natural human immune system and the immunopathogenesis of chronic hepatitis C (literature review)
by: T.I. Koval, et al.
Published: (2022-12-01)
by: T.I. Koval, et al.
Published: (2022-12-01)
Protective effect of TLR2/TLR9 agonists on pulmonary Acinetobacter baumannii infection in mice
by: CHENG Hao, et al.
Published: (2024-04-01)
by: CHENG Hao, et al.
Published: (2024-04-01)
TLR3, TLR7, and TLR8 genes expression datasets in COVID-19 patients: Influences of the disease severity and gender
by: Nasir Arefinia, et al.
Published: (2024-06-01)
by: Nasir Arefinia, et al.
Published: (2024-06-01)
Diagnostic significance of TLR2 and TLR4 receptors on lymphoid cells as a marker of the progression of periodontal inflammation associated with key periodontal pathogenic species <i>F. alocis</i> and <i>P. gingivalis</i>
by: Viktor N. Tsarev, et al.
Published: (2022-12-01)
by: Viktor N. Tsarev, et al.
Published: (2022-12-01)
Targeting Inflammation Driven by HMGB1 in Bacterial Keratitis—A Review
by: Linda D. Hazlett, et al.
Published: (2021-09-01)
by: Linda D. Hazlett, et al.
Published: (2021-09-01)
RIGI, TLR7, and TLR3 Genes Were Predicted to Have Immune Response Against Avian Influenza in Indigenous Ducks
by: Aruna Pal, et al.
Published: (2021-12-01)
by: Aruna Pal, et al.
Published: (2021-12-01)
Comparative efficacy of inhaled corticosteroids and leukotriene modifiers depending on ASP299GLY-TLR-4 polymorphism in patients with bronchial asthma in the population of AR Crimea
by: Bisyuk Yu.A., et al.
Published: (2015-09-01)
by: Bisyuk Yu.A., et al.
Published: (2015-09-01)
Comparative efficacy of inhaled corticosteroids and leukotriene modifiers depending on ASP299GLY-TLR-4 polymorphism in patients with bronchial asthma in the population of AR Crimea.
by: Yu. A. Bisyuk, et al.
Published: (2015-09-01)
by: Yu. A. Bisyuk, et al.
Published: (2015-09-01)
Alterations of Plasma Biochemical and Immunological Parameters and Spatiotemporal Expression of TLR2 and TLR9 in Gibel Carp (<i>Carassius auratus gibelio</i>) after CyHV-2 Infection
by: Jinwei Gao, et al.
Published: (2023-11-01)
by: Jinwei Gao, et al.
Published: (2023-11-01)
TLR2 and TLR9 Blockade Using Specific Intrabodies Inhibits Inflammation-Mediated Pancreatic Cancer Cell Growth
by: Amrendra K. Ajay, et al.
Published: (2024-02-01)
by: Amrendra K. Ajay, et al.
Published: (2024-02-01)
Hyperexpression of TLR2 and TLR4 in patients with ischemic stroke in acute period of the disease
by: L. V. Gankovskaya, et al.
Published: (2020-08-01)
by: L. V. Gankovskaya, et al.
Published: (2020-08-01)
Cold stress elevates HSP70, TLR2 and TLR4 of indigenous chicken
by: V RALTE, et al.
Published: (2022-03-01)
by: V RALTE, et al.
Published: (2022-03-01)
Randomized controlled trial of vitamin d supplementation on toll-like receptor-2 (tlr-2) and toll-like receptor-4 (tlr-4) in tuberculosis spondylitis patients
by: Jainal Arifin, et al.
Published: (2023-12-01)
by: Jainal Arifin, et al.
Published: (2023-12-01)
Toll-like receptor (TLR2, TLR4) polymorphisms and their influence on the incidence of urinary tract infections in children with and without urinary tract malformation
by: Anna Krakowska, et al.
Published: (2022-09-01)
by: Anna Krakowska, et al.
Published: (2022-09-01)
Association of polymorphisms in TLR3 and TLR7 genes with susceptibility to COVID-19 among Iranian population: a retrospective case-control study
by: Masoud Parsania, et al.
Published: (2024-02-01)
by: Masoud Parsania, et al.
Published: (2024-02-01)
Peculiarities of TLR-2 (Arg753Gln) and TLR-4 (Asp299Gly) polymorphism prevalence in patients with acute brucellosis with cardiovascular lesions
by: Elchin Huseynov Mammad oglu
Published: (2018-10-01)
by: Elchin Huseynov Mammad oglu
Published: (2018-10-01)
Effect of agar and biofilm culture of <i>Francisella tularensis</i> on TLR2 and TLR4 genes expression in blood and spleen cells of experimental animals
by: V. I. Dubrovina, et al.
Published: (2025-07-01)
by: V. I. Dubrovina, et al.
Published: (2025-07-01)
Association of single nucleotide polymorphisms of <i>TLR2</i>, <i>TLR4</i> and <i>TLR9</i> with atopic dermatitis
by: O. A. Svitich, et al.
Published: (2023-06-01)
by: O. A. Svitich, et al.
Published: (2023-06-01)
Impact of TLR9 and TLR7 gene polymorphisms on prognosis and survival of patients with oral squamous cell carcinoma
by: Miroslav Obrenović, et al.
Published: (2024-06-01)
by: Miroslav Obrenović, et al.
Published: (2024-06-01)
Lipid raft localization of TLR2 and its co-receptors is independent of membrane lipid composition
by: Christine Hellwing, et al.
Published: (2018-01-01)
by: Christine Hellwing, et al.
Published: (2018-01-01)
ПОЛІМОРФНИЙ АЛЕЛЬ 299GLY ГЕНА TLR4 АСОЦІЮЄТЬСЯ ІЗ ЗНИЖЕНОЮ ЕФЕКТИВНІСТЮ ВКЛЮЧЕННЯ У КОМПЛЕКСНУ ТЕРАПІЮ ХВОРИХ НА ІШЕМІЧНУ ХВОРОБУ СЕРЦЯ АЗИТРОМІЦИНУ ТА ПІОГЛІТАЗОНУ
by: O.V. Skochko
Published: (2018-07-01)
by: O.V. Skochko
Published: (2018-07-01)
Influence of Age and Immunostimulation on the Level of Toll-Like Receptor Gene (<i>TLR3</i>, <i>4</i>, and <i>7</i>) Expression in Foals
by: Anna Migdał, et al.
Published: (2020-10-01)
by: Anna Migdał, et al.
Published: (2020-10-01)
TLR2 AND TLR4 EXPRESSION ON BLOOD MONOCYTES AND GRANULOCYTES OF CARDIAC SURGICAL PATIENTS IS NOT AFFECTED BY THE USE OF CARDIOPULMONARY BYPASS
by: Jan Krejsek, et al.
Published: (2013-01-01)
by: Jan Krejsek, et al.
Published: (2013-01-01)
NOD2 Modulates Serotonin Transporter and Interacts with TLR2 and TLR4 in Intestinal Epithelial Cells
by: Elena Layunta, et al.
Published: (2018-06-01)
by: Elena Layunta, et al.
Published: (2018-06-01)
Reactivating Immunity Primed by Acellular Pertussis Vaccines in the Absence of Circulating Antibodies: Enhanced Bacterial Control by TLR9 Rather Than TLR4 Agonist-Including Formulation
by: Floriane Auderset, et al.
Published: (2019-07-01)
by: Floriane Auderset, et al.
Published: (2019-07-01)
Expression of TLR2 and TLR4 in lesions of patients with tegumentary american leishmaniasis
by: Felipe Francisco Tuon, et al.
Published: (2012-06-01)
by: Felipe Francisco Tuon, et al.
Published: (2012-06-01)
Paralogues From the Expanded Tlr11 Gene Family in Mudskipper (Boleophthalmus pectinirostris) Are Under Positive Selection and Respond Differently to LPS/Poly(I:C) Challenge
by: Heng Tong Qiu, et al.
Published: (2019-02-01)
by: Heng Tong Qiu, et al.
Published: (2019-02-01)
The expression of genes TLR2 and TLR10 in the gastric tissue of patients with gastroduodenal disorders caused by Helicobacter pylori
by: Samara Kadhim Mohammed, et al.
Published: (2024-08-01)
by: Samara Kadhim Mohammed, et al.
Published: (2024-08-01)
Lactobacillus fermentum CECT5716 Alleviates the Inflammatory Response in Asthma by Regulating TLR2/TLR4 Expression
by: Weifang Wang, et al.
Published: (2022-07-01)
by: Weifang Wang, et al.
Published: (2022-07-01)
Basophil activation through TLR2 and TLR4 signaling pathways
by: Manal Alkan, et al.
Published: (2018-08-01)
by: Manal Alkan, et al.
Published: (2018-08-01)
Similar Items
-
Single nucleotide polymorphisms of TLR-2, TLR-3, TLR-4 and susceptibility to inflammatory diseases of the respiratory tract
by: N. O. Pryimenko, et al.
Published: (2018-10-01) -
Single Nucleotide Variants in the TLR1, TLR2 and TLR6 Genes: A Case–Control Study in a Colombian Population
by: Luz D. Gutierrez-Castañeda, et al.
Published: (2023-10-01) -
Paroxetine effect on expression of TLR2 and TLR4 genes in PBMCs of mentally normal individuals
by: Fatemeh Ganjalishahi, et al.
Published: (2021-08-01) -
The Relevance of TLR8 in Viral Infections
by: Iván Martínez-Espinoza, et al.
Published: (2022-01-01) -
Effects of Glycyrrhizin on Multi-Drug Resistant <i>Pseudomonas aeruginosa</i>
by: Nicholas J. Carruthers, et al.
Published: (2020-09-01)
