| Summary: | Background. Study of changes in biochemical and morphological parameters in rats with experimental atherosclerosis and the influence of plant complexes on them. Materials and methods. On a cholesterol model of atherosclerosis in rats, the hypolipidemic, hypoglycemic, cardioprotective, and hepatoprotective effects of plant complexes were studied: 1st – based on garlic and beetroot, 2nd – based on dioscorea, hawthorn, red clover, and beetroot, 3rd – based on thyme, blueberry, horsetail, and rose hips. Results. It was found that the most effective herbal complex for hyperlipidemia with elevated levels of low-density lipoproteins was based on blueberries, and for hypertriglyceridemia - based on garlic. All the studied herbal complexes have a hepatoprotective and cardioprotective effect, improving the biochemical parameters and morphological picture of liver and heart tissue in atherosclerosis, and also normalize uric acid metabolism. The herbal complex based on garlic has a pronounced sugar-lowering effect. Possible mechanisms of action of the studied herbal complexes are discussed. Conclusions. The obtained results indicate the presence of high hypolipidemic activity and pleiotropic effects in plant complexes based on garlic, blueberries and dioscorea.
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