To Explore the Pathogenesis of Vascular Lesion of Type 2 Diabetes Mellitus Based on the PI3K/Akt Signaling Pathway

Background. Type 2 diabetes mellitus (T2DM) has become a chronic disease, serious harm to human health. Complications of the blood pipe are the main cause of disability and death in diabetic patients, including vascular lesions that directly affects the prognosis of patients with diabetes and surviv...

Full description

Bibliographic Details
Published in:	Journal of Diabetes Research
Main Authors:	Jia-Rong Gao, Xiu-Juan Qin, Zhao-Hui Fang, Li-Shan, Li-Ping Han, Hui-Jiang, Ming-Fei Guo, Nan-Nan Jiang
Format:	Article
Language:	English
Published:	Wiley 2019-01-01
Online Access:	http://dx.doi.org/10.1155/2019/4650906

Similar Items

LDLR promotes autophagy‐mediated cisplatin resistance in ovarian cancer associated with the PI3K/AKT/mTOR signaling pathway
by: Lei Liu, et al.
Published: (2023-08-01)

PI3K/AKT/mTOR Signaling Pathway Is Downregulated by Runzaoling (RZL) in Sjögren’s Syndrome
by: Ping Zeng, et al.
Published: (2022-01-01)

Yangxue Jiedu Fang Ameliorates Psoriasis by Regulating Vascular Regression via Survivin/PI3K/Akt Pathway
by: Hongpeng Lv, et al.
Published: (2021-01-01)

PI3K/AKT/mTOR Axis in Cancer: From Pathogenesis to Treatment
by: Mingyang Jiang, et al.
Published: (2025-08-01)

Eriodictyol Suppresses Gastric Cancer Cells via Inhibition of PI3K/AKT Pathway
by: Hui Shan, et al.
Published: (2022-11-01)

PI3K/AKT Pathway and Brain Malformations
by: Gavin B. Rice, et al.
Published: (2015-07-01)

Endometriosis-Associated Ovarian Carcinomas: How PI3K/AKT/mTOR Pathway Affects Their Pathogenesis
by: Tatiana S. Driva, et al.
Published: (2023-08-01)

Gas6 Delays Senescence in Vascular Smooth Muscle Cells through the PI3K/ Akt/FoxO Signaling Pathway
by: Cheng-wei Jin, et al.
Published: (2015-02-01)

Omentin-1 Stimulates Human Osteoblast Proliferation through PI3K/Akt Signal Pathway
by: Shan-Shan Wu, et al.
Published: (2013-01-01)

Upregulation of MMPs in placentas of patients with gestational diabetes mellitus: Involvement of the PI3K/Akt pathway
by: Yanan Zhang, et al.
Published: (2024-06-01)

Thioguanine Induces Apoptosis in Triple-Negative Breast Cancer by Regulating PI3K–AKT Pathway
by: Daoyu Zhang, et al.
Published: (2020-10-01)

Strictosamide promotes wound healing through activation of the PI3K/AKT pathway
by: Gu-xu Ming, et al.
Published: (2024-05-01)

Bioactive compound combinations from Rhodiola tangutica alleviate pulmonary vascular remodeling in high-altitude pulmonary hypertension rats through the PI3K–AKT pathway
by: Na Yang, et al.
Published: (2025-05-01)

Pericyte-derived extracellular vesicles improve vascular barrier function in sepsis via the Angpt1/PI3K/AKT pathway and pericyte recruitment: an in vivo and in vitro study
by: Zi-sen Zhang, et al.
Published: (2025-02-01)

PI3K/AKT/mTOR pathway in Angiogenesis
by: Jayashree eKarar, et al.
Published: (2011-12-01)

VEGFB ameliorates insulin resistance in NAFLD via the PI3K/AKT signal pathway
by: Yuqi Li, et al.
Published: (2024-10-01)

Targeting AKT1-E17K and the PI3K/AKT Pathway with an Allosteric AKT Inhibitor, ARQ 092.
by: Yi Yu, et al.
Published: (2015-01-01)

Rhein promotes skin wound healing by activating the PI3K/AKT signaling pathway
by: Yang Dong, et al.
Published: (2024-12-01)

Role of the ALK gene and PI3K/Akt/NF-κB signaling pathway in cervical cancer precancerous lesions
by: Zhengran Sun, et al.
Published: (2025-09-01)

Inhibition of PI3K/AKT/GLUT1 Signaling Pathway by Quercetin in the Treatment of Psoriasis
by: Jie Ma, et al.
Published: (2025-02-01)

Correlation between activation of PI3K/AKT/mTOR pathway and prognosis of breast cancer in Chinese women.
by: Ling Deng, et al.
Published: (2015-01-01)

PI3K/AKT signaling pathway plays an important role in the pathogenesis of metabolic dysfunction-associated steatotic liver disease
by: Cuiping Shao, et al.
Published: (2025-07-01)

CCDC58 drives lung adenocarcinoma progression via the PI3K/AKT signaling pathway
by: Wenchao Dai, et al.
Published: (2025-09-01)

Electroacupuncture on GB acupoints improves osteoporosis via the estradiol–PI3K–Akt signaling pathway
by: Wang Xinyu, et al.
Published: (2024-11-01)

Effects of asiaticoside on the model of gestational diabetes mellitus in HTR-8/svneo cells via PI3K/AKT pathway
by: Zhilan Hu, et al.
Published: (2024-12-01)

Low Dose of Lipopolysaccharide Pretreatment Preventing Subsequent Endotoxin-Induced Uveitis Is Associated with PI3K/AKT Pathway
by: Nan Zhang, et al.
Published: (2017-01-01)

The Effect of Tianmai Xiaoke Pian on Insulin Resistance through PI3-K/AKT Signal Pathway
by: Nana Wang, et al.
Published: (2016-01-01)

Sufentanil enhances the cortical neurogenesis of rats with traumatic brain injury via PI3K/AKT signal pathway
by: Wei Gu, et al.
Published: (2025-02-01)

CeRNA-based regulatory mechanisms underlying the antioxidant action of quercetin in ox-LDL-induced HUVECs damage: Roles of MALAT1 in PTEN/PI3K/AKT signaling pathway
by: Yang Jiang, et al.
Published: (2024-06-01)

PI3K/Akt pathway and neuroinflammation in sepsis-associated encephalopathy
by: Guo Yang, et al.
Published: (2025-08-01)

Activation of the PI3K-AKT Pathway by Old World Alphaviruses
by: Eline Van Huizen, et al.
Published: (2020-04-01)

Effect of Electroacupuncture on Chondrocyte Apoptosis in Knee Osteoarthritis Rat Based on PI3K/Akt Signaling Pathway
by: Yuanyuan ZHANG, et al.
Published: (2019-08-01)

BTC as a Novel Biomarker Contributing to EMT via the PI3K-AKT Pathway in OSCC
by: Ting Shen, et al.
Published: (2022-07-01)

Geniposide promotes wound healing of skin ulcers in diabetic rats through PI3K/Akt pathway
by: Chun-juan Fang, et al.
Published: (2023-11-01)

SATB2 promotes humeral fracture healing in rats by activating the PI3K/AKT pathway
by: Liu Liantao, et al.
Published: (2025-08-01)

Curzerene suppresses hepatocellular carcinoma progression through the PI3K/AKT/MTOR pathway
by: Yihui Luo, et al.
Published: (2024-10-01)

PTEN regulates BCRP/ABCG2 and the side population through the PI3K/Akt pathway in chronic myeloid leukemia.
by: Fang-Fang Huang, et al.
Published: (2014-01-01)

RSRC1 inhibits the proliferation and metastasis of ESCC by targeting PTEN/PI3K/AKT pathway
by: Zhou Jiatian, Shang Guansheng, Zhang Cong, Jiang Dexiong, Yuan Dongdong, Tang Dengyao, Zhou Jiang
Published: (2023-10-01)

Cardamonin inhibits silicosis development through the PI3K-AKT signaling pathway
by: Zhimin Ye, et al.
Published: (2024-10-01)

LINC01370 suppresses hepatocellular carcinoma proliferation and metastasis by regulating the PI3K/AKT pathway
by: Fei Xiao, et al.
Published: (2024-08-01)