Salidroside Ameliorates Alzheimer's Disease by Targeting NLRP3 Inflammasome-Mediated Pyroptosis

Amyloid β-protein (Aβ) is reported to activate NLRP3 inflammasomes and drive pyroptosis, which is subsequently involved in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease (AD). To date, the pathogenesis of AD is unfortunately insufficiently elucidated. Therefore, thi...

Full description

Bibliographic Details
Published in:	Frontiers in Aging Neuroscience
Main Authors:	Yawen Cai, Yuhui Chai, Yu Fu, Yingdi Wang, Yiming Zhang, Xue Zhang, Lingpeng Zhu, Mingxing Miao, Tianhua Yan
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-01-01
Subjects:	Alzheimer's disease salidroside pyroptosis NLRP3 inflammasome TLR4
Online Access:	https://www.frontiersin.org/articles/10.3389/fnagi.2021.809433/full

Similar Items

Salidroside ameliorates neuroinflammation in autistic rats by inhibiting NLRP3/Caspase-1/GSDMD signal pathway
by: Qingwei Wu, et al.
Published: (2025-01-01)

Neuroprotection of Emodin by Inhibition of Microglial NLRP3 Inflammasome-Mediated Pyroptosis
by: Wen Jiang, et al.
Published: (2023-03-01)

Correlation of Inflammasomes with Pyroptosis and Effect on Coagulation Function
by: GAO Jiawei, et al.
Published: (2024-11-01)

Oxymatrine Attenuates Ulcerative Colitis through Inhibiting Pyroptosis Mediated by the NLRP3 Inflammasome
by: Jing Sun, et al.
Published: (2024-06-01)

NLRP3 inflammasome and pyroptosis in cardiovascular diseases and exercise intervention
by: Ping Ding, et al.
Published: (2024-04-01)

NLRP3 inflammasome-induced pyroptosis in digestive system tumors
by: Jiexia Wen, et al.
Published: (2023-04-01)

Enhanced Cardiomyocyte NLRP3 Inflammasome‐Mediated Pyroptosis Promotes d‐Galactose–Induced Cardiac Aging
by: Wen‐bin Liu, et al.
Published: (2024-07-01)

ChemR23 signaling ameliorates brain injury via inhibiting NLRP3 inflammasome-mediated neuronal pyroptosis in ischemic stroke
by: Lan Liu, et al.
Published: (2024-01-01)

The Abilities of Salidroside on Ameliorating Inflammation, Skewing the Imbalanced Nucleotide Oligomerization Domain-Like Receptor Family Pyrin Domain Containing 3/Autophagy, and Maintaining Intestinal Barrier Are Profitable in Colitis
by: Jiuxi Liu, et al.
Published: (2019-12-01)

Promiscuous Inflammasomes: The False Dichotomy of RNA/DNA Virus-Induced Inflammasome Activation and Pyroptosis
by: Hannah L. Wallace, et al.
Published: (2022-09-01)

Curcumin ameliorates hyperuricemia and gout‐induced damage via modulating the ROS‐dependent NEK7‐NLRP3 inflammasome activation
by: Zhengtian Zhao, et al.
Published: (2025-09-01)

Apelin ameliorates sepsis-induced myocardial dysfunction via inhibition of NLRP3-mediated pyroptosis of cardiomyocytes
by: Zhi Cao, et al.
Published: (2024-02-01)

Research Pogress on Action Mechanism of NLRP3 Inflammasome and Pyroptosis in Diabetic Nephropathy
by: LEI Zhenyun, et al.
Published: (2025-04-01)

Phospholipid transfer protein ameliorates sepsis-induced cardiac dysfunction through NLRP3 inflammasome inhibition
by: Wang Jian, et al.
Published: (2024-03-01)

Silibinin ameliorates deoxycholic acid-induced pyroptosis in steatotic HepG2 cells by inhibiting NLRP3 inflammasome activation
by: Meiqing Mai, et al.
Published: (2023-09-01)

TMBIM4 Deficiency Facilitates NLRP3 Inflammasome Activation-Induced Pyroptosis of Trophoblasts: A Potential Pathogenesis of Preeclampsia
by: Yuanyao Chen, et al.
Published: (2023-01-01)

Pyroptosis in NLRP3 inflammasome-related atherosclerosis
by: Xiang Zeng, et al.
Published: (2022-10-01)

Aloe-Emodin Derivative, an Anthraquinone Compound, Attenuates Pyroptosis by Targeting NLRP3 Inflammasome in Diabetic Cardiomyopathy
by: Yingying Hu, et al.
Published: (2023-09-01)

TIGAR deficiency induces caspase-1-dependent trophoblasts pyroptosis through NLRP3-ASC inflammasome
by: Junjun Guo, et al.
Published: (2023-04-01)

Ischemic Preconditioning Provides Neuroprotection by Inhibiting NLRP3 Inflammasome Activation and Cell Pyroptosis
by: Li Gao, et al.
Published: (2023-06-01)

Microcystin-LR Induces and Aggravates Colitis through NLRP3 Inflammasome-Mediated Pyroptosis in Mice
by: Yue Yang, et al.
Published: (2023-07-01)

Baicalein Suppresses NLRP3 and AIM2 Inflammasome-Mediated Pyroptosis in Macrophages Infected by Mycobacterium tuberculosis via Induced Autophagy
by: Bangzuo Ning, et al.
Published: (2023-06-01)

NLRP3 inflammasome in cardiovascular diseases: an update
by: Binhai Mo, et al.
Published: (2025-02-01)

NLRP3 inflammasome and pyroptosis: implications in inflammation and multisystem disorders
by: Xiaodi Li, et al.
Published: (2025-08-01)

Salidroside protects RGC from pyroptosis in diabetes-induced retinopathy associated with NLRP3, NFEZL2 and NGKB1, revealed by network pharmacology analysis and experimental validation
by: Lan-Chun Zhang, et al.
Published: (2024-01-01)

Shikonin from lithospermum erythrorhizon induces pyroptosis in trophoblast cells by activating the CTSB-NLRP3 inflammasome
by: Fuling Zeng, et al.
Published: (2024-12-01)

Microtubule affinity regulating kinase 4 promoted activation of the NLRP3 inflammasome-mediated pyroptosis in periodontitis
by: Lulu Wang, et al.
Published: (2022-12-01)

TAK-242 alleviates diabetic cardiomyopathy via inhibiting pyroptosis and TLR4/CaMKII/NLRP3 pathway
by: Zhao Xiaolong, et al.
Published: (2024-09-01)

The role of NLRP3 inflammasome in hepatocellular carcinoma
by: Huijie Zhao, et al.
Published: (2023-04-01)

Geniposide suppresses NLRP3 inflammasome-mediated pyroptosis via the AMPK signaling pathway to mitigate myocardial ischemia/reperfusion injury
by: Haiyan Li, et al.
Published: (2022-06-01)

The Novel Role of the NLRP3 Inflammasome in Mycotoxin-Induced Toxicological Mechanisms
by: Chengshui Liao, et al.
Published: (2024-06-01)

HHcy Induces Pyroptosis and Atherosclerosis via the Lipid Raft-Mediated NOX-ROS-NLRP3 Inflammasome Pathway in apoE<sup>−/−</sup> Mice
by: Sijun Liu, et al.
Published: (2022-08-01)

Hydrogen Sulfide Prevents LPS-Induced Depression-like Behavior through the Suppression of NLRP3 Inflammasome and Pyroptosis and the Improvement of Mitochondrial Function in the Hippocampus of Mice
by: Peng Bao, et al.
Published: (2023-08-01)

Lactobacillus Plantarum Promotes Wound Healing by Inhibiting the NLRP3 Inflammasome and Pyroptosis Activation in Diabetic Foot Wounds
by: Wang X, et al.
Published: (2024-03-01)

Ochratoxin A induces NLRP3 inflammasome-mediated pyroptosis via activation of ROS modulated by autophagy in vitro
by: Kai Liu, et al.
Published: (2021-12-01)

NLRP3 inflammasome: The rising star in cardiovascular diseases
by: Yidan Zheng, et al.
Published: (2022-09-01)

Bushen Huoxue Acupuncture Inhibits NLRP1 Inflammasome-Mediated Neuronal Pyroptosis in SAMP8 Mouse Model of Alzheimer’s Disease
by: Zhang T, et al.
Published: (2021-02-01)

Mechanistic and therapeutic insights into the function of NLRP3 inflammasome in sterile arthritis
by: Yi Xiao, et al.
Published: (2023-10-01)

The Impact of NLRP3 Inflammasome on Osteoblasts and Osteogenic Differentiation: A Literature Review
by: Yang Z, et al.
Published: (2024-04-01)

Dietary disodium fumarate supplementation alleviates subacute ruminal acidosis (SARA)-induced liver damage by inhibiting pyroptosis via mitophagy-NLRP3 inflammasome pathway in lactating Hu sheep
by: Hongzhu Zhang, et al.
Published: (2023-05-01)