Systemic Factors Affecting Human Beta-Defensins in Oral Cavity
Human beta-defensins are host defense peptides with broad antimicrobial and inflammatory functions. In the oral cavity, these peptides are produced mainly by the keratinocytes of the epithelium; however, fibroblasts, monocytes, and macrophages also contribute to oral human beta-defensin expressions....
| 发表在: | Pathogens |
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| Main Authors: | , , , |
| 格式: | 文件 |
| 语言: | 英语 |
| 出版: |
MDPI AG
2024-08-01
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| 在线阅读: | https://www.mdpi.com/2076-0817/13/8/654 |
| _version_ | 1849742348823560192 |
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| author | Nur Atalay Nur Balci Mervi Gürsoy Ulvi Kahraman Gürsoy |
| author_facet | Nur Atalay Nur Balci Mervi Gürsoy Ulvi Kahraman Gürsoy |
| author_sort | Nur Atalay |
| collection | DOAJ |
| container_title | Pathogens |
| description | Human beta-defensins are host defense peptides with broad antimicrobial and inflammatory functions. In the oral cavity, these peptides are produced mainly by the keratinocytes of the epithelium; however, fibroblasts, monocytes, and macrophages also contribute to oral human beta-defensin expressions. The resident and immune cells of the oral cavity come into contact with various microbe-associated molecular patterns continuously and simultaneously. The overall antimicrobial cellular response is highly influenced by local and environmental factors. Recent studies have produced evidence showing that not only systemic chronic diseases but also systemic factors like hyperglycemia, pregnancy, the long-term use of certain vitamins, and aging can modulate oral cellular antimicrobial responses against microbial challenges. Therefore, the aim of this narrative review is to discuss the role of systemic factors on oral human beta-defensin expressions. |
| format | Article |
| id | doaj-art-23eabd64d28e43b2abb6f4e18cb01c29 |
| institution | Directory of Open Access Journals |
| issn | 2076-0817 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| spelling | doaj-art-23eabd64d28e43b2abb6f4e18cb01c292025-08-20T01:45:34ZengMDPI AGPathogens2076-08172024-08-0113865410.3390/pathogens13080654Systemic Factors Affecting Human Beta-Defensins in Oral CavityNur Atalay0Nur Balci1Mervi Gürsoy2Ulvi Kahraman Gürsoy3Department of Periodontology, Institute of Dentistry, University of Turku, Lemminkäisenkatu 2, 20520 Turku, FinlandDepartment of Periodontology, Faculty of Dentistry, Medipol University, Goztepe Mahallesi, Ataturk Caddesi 40, Beykoz, 34815 Istanbul, TurkeyDepartment of Periodontology, Institute of Dentistry, University of Turku, Lemminkäisenkatu 2, 20520 Turku, FinlandDepartment of Periodontology, Institute of Dentistry, University of Turku, Lemminkäisenkatu 2, 20520 Turku, FinlandHuman beta-defensins are host defense peptides with broad antimicrobial and inflammatory functions. In the oral cavity, these peptides are produced mainly by the keratinocytes of the epithelium; however, fibroblasts, monocytes, and macrophages also contribute to oral human beta-defensin expressions. The resident and immune cells of the oral cavity come into contact with various microbe-associated molecular patterns continuously and simultaneously. The overall antimicrobial cellular response is highly influenced by local and environmental factors. Recent studies have produced evidence showing that not only systemic chronic diseases but also systemic factors like hyperglycemia, pregnancy, the long-term use of certain vitamins, and aging can modulate oral cellular antimicrobial responses against microbial challenges. Therefore, the aim of this narrative review is to discuss the role of systemic factors on oral human beta-defensin expressions.https://www.mdpi.com/2076-0817/13/8/654defensinsperiodontiumperiodontal diseasesretinoidsvitamin Daging |
| spellingShingle | Nur Atalay Nur Balci Mervi Gürsoy Ulvi Kahraman Gürsoy Systemic Factors Affecting Human Beta-Defensins in Oral Cavity defensins periodontium periodontal diseases retinoids vitamin D aging |
| title | Systemic Factors Affecting Human Beta-Defensins in Oral Cavity |
| title_full | Systemic Factors Affecting Human Beta-Defensins in Oral Cavity |
| title_fullStr | Systemic Factors Affecting Human Beta-Defensins in Oral Cavity |
| title_full_unstemmed | Systemic Factors Affecting Human Beta-Defensins in Oral Cavity |
| title_short | Systemic Factors Affecting Human Beta-Defensins in Oral Cavity |
| title_sort | systemic factors affecting human beta defensins in oral cavity |
| topic | defensins periodontium periodontal diseases retinoids vitamin D aging |
| url | https://www.mdpi.com/2076-0817/13/8/654 |
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