Entropy and Fractal Dimension Study of the TDP-43 Protein Low Complexity Domain Sequence in ALS Disease Severity and SARS-CoV-2 Gene Sequences in Virulence Variability

The low complexity domain (LCD) sequence has been defined in terms of entropy using a 12 amino acid sliding window along a protein sequence in the study of disease-related genes. The amyotrophic lateral sclerosis (ALS)-related TDP-43 protein sequence with intra-LCD structural information based on cr...

Full description

Bibliographic Details
Published in:	Entropy
Main Authors:	Sunil Dehipawala, Eric Cheung, George Tremberger, Tak Cheung
Format:	Article
Language:	English
Published:	MDPI AG 2021-08-01
Subjects:	entropy fractal dimension TDP-43 low complexity domain sequence SARS-CoV-2 HAR1
Online Access:	https://www.mdpi.com/1099-4300/23/8/1038

Similar Items

Aberrant TDP‐43 phosphorylation: a key wind gap from TDP‐43 to TDP‐43 proteinopathy
by: Zi‐Qi Huang, et al.
Published: (2021-06-01)

Optineurin knock-out forms TDP-43 aggregates to regulate TDP-43 protein levels despite autophagic up-regulation and aberrant TDP-43 expression
by: Yuta Maetani, et al.
Published: (2025-07-01)

TDP-43-M323K causes abnormal brain development and progressive cognitive and motor deficits associated with mislocalised and increased levels of TDP-43
by: Juan M. Godoy-Corchuelo, et al.
Published: (2024-04-01)

RNA-binding deficient TDP-43 drives cognitive decline in a mouse model of TDP-43 proteinopathy
by: Julie C Necarsulmer, et al.
Published: (2023-10-01)

Prion-like Spreading of Disease in TDP-43 Proteinopathies
by: Emma Pongrácová, et al.
Published: (2024-11-01)

Optogenetic TDP-43 nucleation induces persistent insoluble species and progressive motor dysfunction in vivo
by: Charlton G. Otte, et al.
Published: (2020-12-01)

Cryptic Splicing of GAP43 mRNA is a Novel Hallmark of TDP‐43‐Associated ALS and AD
by: Mingming Yang, et al.
Published: (2025-09-01)

TDP-43-proteinopathy at the crossroads of tauopathy: on copathology and current and prospective biomarkers
by: Abdul R. Nasir, et al.
Published: (2025-10-01)

TDP-43 regulates cancer-associated microRNAs
by: Xiaowei Chen, et al.
Published: (2017-09-01)

Stress Granule Assembly Can Facilitate but Is Not Required for TDP-43 Cytoplasmic Aggregation
by: Nikita Fernandes, et al.
Published: (2020-09-01)

The Role of TAR DNA Binding Protein 43 (TDP-43) as a CandiDate Biomarker of Amyotrophic Lateral Sclerosis: A Systematic Review and Meta-Analysis
by: Caterina Maria Gambino, et al.
Published: (2023-01-01)

TDP-43 pathology is sufficient to drive axon initial segment plasticity and hyperexcitability of spinal motoneurones in vivo in the TDP43-ΔNLS model of Amyotrophic Lateral Sclerosis
by: Svetlana Djukic, et al.
Published: (2025-02-01)

Novel in vivo TDP-43 stress reporter models to accelerate drug development in ALS
by: Febe Ferro, et al.
Published: (2024-10-01)

Conditioned Medium from Cells Overexpressing TDP-43 Alters the Metabolome of Recipient Cells
by: Rudolf Hergesheimer, et al.
Published: (2020-09-01)

Codon-optimized TDP-43 mediates neurodegeneration in a Drosophila model of ALS/FTLD
by: Tanzeen Yusuff, et al.
Published: (2023-03-01)

Low T-cell reactivity to TDP-43 peptides in ALS
by: Swetha Ramachandran, et al.
Published: (2023-07-01)

Mechanisms underlying TDP-43 pathology and neurodegeneration: An updated Mini-Review
by: Benjamin I. Nilaver, et al.
Published: (2023-03-01)

CK1δ/ε kinases regulate TDP-43 phosphorylation and are therapeutic targets for ALS-related TDP-43 hyperphosphorylation
by: Vivian I. Ko, et al.
Published: (2024-06-01)

The role of adiponectin-AMPK axis in TDP-43 mislocalization and disease severity in ALS
by: Yu-Ju Liu, et al.
Published: (2024-11-01)

TDP-43 Secretion via Extracellular Vesicles Is Regulated by Macroautophagy
by: Yoshinori Tanaka, et al.
Published: (2024-12-01)

Incidence and morphology of secondary TDP-43 proteinopathies: Part 2
by: Albert Acewicz, et al.
Published: (2023-07-01)

Targeting the TDP-43 low complexity domain blocks spreading of pathology in a mouse model of ALS/FTD
by: Elodie Chevalier, et al.
Published: (2024-10-01)

Mitochondrion-Dependent Cell Death in TDP-43 Proteinopathies
by: Chantal B. Lucini, et al.
Published: (2021-04-01)

TDP-43 ameliorates aging-related cartilage degradation through preventing chondrocyte senescence
by: Limeiting Wang, et al.
Published: (2024-10-01)

Methylome analysis of FTLD patients with TDP-43 pathology identifies epigenetic signatures specific to pathological subtypes
by: Cristina T. Vicente, et al.
Published: (2025-07-01)

Effect of icaritin on autophagy-related protein expression in TDP-43-transfected SH-SY5Y cells
by: Yanjun Zhou, et al.
Published: (2022-07-01)

Maintenance of neuronal TDP-43 expression requires axonal lysosome transport
by: Veronica H Ryan, et al.
Published: (2025-09-01)

c-Abl Regulates the Pathological Deposition of TDP-43 via Tyrosine 43 Phosphorylation
by: Saebom Lee, et al.
Published: (2022-12-01)

TDP-43 Proteinopathy Specific Biomarker Development
by: Isabell Cordts, et al.
Published: (2023-02-01)

TDP-43 as a potential retinal biomarker for neurodegenerative diseases
by: Margit Glashutter, et al.
Published: (2025-02-01)

TDP-43 Cytoplasmic Translocation in the Skin Fibroblasts of ALS Patients
by: Miguel A. Rubio, et al.
Published: (2022-01-01)

Effects of TDP-43 on mouse gingival fibroblasts stimulated by LPS: An experimental study
by: XU Huilin, et al.
Published: (2024-08-01)

Frontotemporal Lobar degeneration with TDP-43 presenting as progressive supranuclear palsy syndrome
by: Aya Murakami, et al.
Published: (2025-07-01)

A stress-dependent TDP-43 SUMOylation program preserves neuronal function
by: Terry R. Suk, et al.
Published: (2025-03-01)

Cyclin F can alter the turnover of TDP-43
by: Stephanie L. Rayner, et al.
Published: (2024-03-01)

HDAC1 dysregulation induces aberrant cell cycle and DNA damage in progress of TDP‐43 proteinopathies
by: Cheng‐Chun Wu, et al.
Published: (2020-05-01)

Understanding Limbic-Predominant Age-Related TDP-43 Encephalopathy (LATE): The Intersection of Pathology and Immune Dysregulation
by: Mansi Singh, et al.
Published: (2024-04-01)

The Protective Effect of Edaravone on TDP-43 Plus Oxidative Stress-Induced Neurotoxicity in Neuronal Cells: Analysis of Its Neuroprotective Mechanisms Using RNA Sequencing
by: Aki Soejima-Kusunoki, et al.
Published: (2022-07-01)

Validation of a newly developed immunoassay for TDP-43 in human plasma
by: Sayo Matsuura, et al.
Published: (2024-01-01)

In vivo diagnosis of TDP-43 proteinopathies: in search of biomarkers of clinical use
by: Juan I. López-Carbonero, et al.
Published: (2024-06-01)