| Summary: | The rise of antibiotic-resistant <i>Staphylococcus aureus</i> strains, particularly MRSA, complicates the management of skin and soft tissue infections. This review highlights ultrasonic methodologies as adjunctive therapies to combat <i>S. aureus</i>-driven skin infections and prevent progression to biofilm formation and chronic wounds. Low- and high-frequency ultrasound (LFU and HFU) demonstrate potential in disrupting biofilms, enhancing drug delivery, and promoting tissue repair through cavitation and microbubble activity. These approaches integrate ultrasonic frequencies with microbubbles and therapeutics, such as antibiotics and affimers, to minimize resistance and improve healing. Tailoring the bioeffects of ultrasound on skin structures through localized delivery technologies, including microneedle patches and piezoelectric systems, presents promising solutions for early intervention in skin and soft structure infections (SSSIs).
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