How Does African Swine Fever Virus Evade the cGAS-STING Pathway?

African swine fever (ASF), a highly infectious and devastating disease affecting both domestic pigs and wild boars, is caused by the African swine fever virus (ASFV). ASF has resulted in rapid global spread of the disease, leading to significant economic losses within the swine industry. A significa...

Full description

Bibliographic Details
Published in:	Pathogens
Main Authors:	Can Lin, Chenyang Zhang, Nanhua Chen, François Meurens, Jianzhong Zhu, Wanglong Zheng
Format:	Article
Language:	English
Published:	MDPI AG 2024-11-01
Subjects:	African swine fever virus innate immunity DNA sensing cGAS STING
Online Access:	https://www.mdpi.com/2076-0817/13/11/957

Similar Items

African swine fever virus MGF505-3R inhibits cGAS-STING-mediated IFN-β pathway activation by degrading TBK1
by: Mingyang Cheng, et al.
Published: (2022-06-01)

The Innate Immune DNA Sensing cGAS-STING Signaling Pathway Mediates Anti-PRRSV Function
by: Yulin Xu, et al.
Published: (2021-09-01)

Modulation of Host Antiviral Innate Immunity by African Swine Fever Virus: A Review
by: Wen-Rui He, et al.
Published: (2022-10-01)

The Chicken cGAS–STING Pathway Exerts Interferon-Independent Antiviral Function via Cell Apoptosis
by: Sen Jiang, et al.
Published: (2023-08-01)

The African swine fever virus protease pS273R inhibits DNA sensing cGAS-STING pathway by targeting IKKε
by: Jia Luo, et al.
Published: (2022-12-01)

Porcine cGAS-STING signaling induced autophagy inhibits STING downstream IFN and apoptosis
by: Nengwen Xia, et al.
Published: (2022-10-01)

The role of cGAS-STING pathway ubiquitination in innate immunity and multiple diseases
by: Chunyan Deng, et al.
Published: (2025-02-01)

Chicken DNA Sensing cGAS-STING Signal Pathway Mediates Broad Spectrum Antiviral Functions
by: Shuangjie Li, et al.
Published: (2020-07-01)

Make it STING: nanotechnological approaches for activating cGAS/STING as an immunomodulatory node in osteosarcoma
by: Jordan C. O’Donoghue, et al.
Published: (2024-09-01)

The cGAS‒STING pathway in cancer immunity: mechanisms, challenges, and therapeutic implications
by: Mengzhou Shen, et al.
Published: (2025-04-01)

Manganese Mediates Its Antiviral Functions in a cGAS-STING Pathway Independent Manner
by: Shaohua Sun, et al.
Published: (2023-02-01)

Temporal Dynamics of Cytokine, Leukocyte, and Whole Blood Transcriptome Profiles of Pigs Infected with African Swine Fever Virus
by: Daniel W. Madden, et al.
Published: (2025-10-01)

Mitophagy and cGAS–STING crosstalk in neuroinflammation
by: Xiaogang Zhou, et al.
Published: (2024-08-01)

Exposure to polystyrene nanoplastics induces abnormal activation of innate immunity via the cGAS-STING pathway
by: Lihui Xuan, et al.
Published: (2024-04-01)

Function and regulation of cGAS-STING signaling in infectious diseases
by: Yang Du, et al.
Published: (2023-02-01)

cGAS-STING pathway in pathogenesis and treatment of osteoarthritis and rheumatoid arthritis
by: XiCheng Yang, et al.
Published: (2024-05-01)

Pathogenicity and virulence of African swine fever virus
by: Ines Ruedas-Torres, et al.
Published: (2024-12-01)

African swine fever virus A151R downregulates cGAS-STING-mediated IFN-β production by promoting lipid peroxidation through ferritinophagy-induced ferroptosis
by: Yiqin Chen, et al.
Published: (2025-06-01)

The interplay between autophagy and cGAS-STING signaling and its implications for cancer
by: Maximilian Schmid, et al.
Published: (2024-04-01)

The crucial roles and research advances of cGAS‑STING pathway in liver diseases
by: Xiaoqian Zhang, et al.
Published: (2024-12-01)

Type I Interferon Response Is Mediated by NLRX1-cGAS-STING Signaling in Brain Injury
by: Lauren E. Fritsch, et al.
Published: (2022-02-01)

The cGAS-STING pathway in atherosclerosis
by: Si-yu Wang, et al.
Published: (2025-04-01)

Corrigendum: Type I Interferon Response Is Mediated by NLRX1-cGAS-STING Signaling in Brain Injury
by: Lauren E. Fritsch, et al.
Published: (2022-06-01)

Porcine cGAS-STING signalling induced apoptosis negatively regulates STING downstream IFN response and autophagy via different mechanisms
by: Nengwen Xia, et al.
Published: (2025-12-01)

The battle between the innate immune cGAS-STING signaling pathway and human herpesvirus infection
by: Ximing Jin, et al.
Published: (2023-08-01)

Correction: The cGAS-STING pathway in atherosclerosis
by: Si-yu Wang, et al.
Published: (2025-06-01)

African Swine Fever Virus: A Review
by: Zhaoyao Li, et al.
Published: (2022-08-01)

Comprehensive elaboration of the cGAS-STING signaling axis in cancer development and immunotherapy
by: Juyan Zheng, et al.
Published: (2020-08-01)

African swine fever virus MGF505–6R attenuates type I interferon production by targeting STING for degradation
by: Manman Yao, et al.
Published: (2024-05-01)

Genetic Variations of African Swine Fever Virus: Major Challenges and Prospects
by: Shengmei Chen, et al.
Published: (2024-06-01)

Dual regulation of the cGAS-STING pathway: new targets and challenges for subtype-specific immunotherapy in breast cancer
by: Hanchu Xiong, et al.
Published: (2025-06-01)

cGAS-STING signaling in cardiovascular diseases
by: Qianxin Zhang, et al.
Published: (2024-05-01)

Focus on the cGAS-STING Signaling Pathway in Sepsis and Its Inflammatory Regulatory Effects
by: Han Y, et al.
Published: (2024-06-01)

The cGAS Paradox: Contrasting Roles for cGAS-STING Pathway in Chromosomal Instability
by: Christy Hong, et al.
Published: (2019-10-01)

African Swine Fever Virus as a Difficult Opponent in the Fight for a Vaccine—Current Data
by: Hanna Turlewicz-Podbielska, et al.
Published: (2021-06-01)

Epidemiological Characterization of African Swine Fever Dynamics in Ukraine, 2012–2023
by: Maksym Bezymennyi, et al.
Published: (2023-06-01)

AFRICAN SWINE FEVER IN POLAND AND EASTERN EUROPE. CURRENT EPIZOOTIC STATUS AND PERSPECTIVES FOR ITS ERADICATION
by: Grzegorz Woźniakowski, et al.
Published: (2021-12-01)

Host Innate and Adaptive Immunity Against African Swine Fever Virus Infection
by: Tianqi Zhang, et al.
Published: (2024-11-01)

African Swine Fever Virus Structural Protein p17 Inhibits Cell Proliferation through ER Stress—ROS Mediated Cell Cycle Arrest
by: Nengwen Xia, et al.
Published: (2020-12-01)

Trafficking and effect of released DNA on cGAS-STING signaling pathway and cardiovascular disease
by: Zimo Zhou, et al.
Published: (2023-12-01)