Synthesis and antioxidant activity study of pyrazoline carrying arylfuran/thiophene moiety

A novel series of N-acetyl-3-aryl-5-(5-(p/o-nitrophenyl)-2-arylfuryl/thienyl) substituted pyrazoline (3a-o) were synthesized by the reaction of 1-aryl-3-(5-(p/o-nitrophenyl)-2-furyl/thienyl)-2-propene-1-one with hydrazine hydrate in acetic acid medium. The structures of the newly synthesize...

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Bibliographic Details
Published in:Journal of the Serbian Chemical Society
Main Authors: Jois Vidyashree H.S., Kalluraya Balakrishna, Girisha K.S.
Format: Article
Language:English
Published: Serbian Chemical Society 2014-01-01
Subjects:
N-acetyl-3,5-disubstituted-pyrazoline
antioxidant activity
aryl-furan
arylthiophene
Online Access:http://www.doiserbia.nb.rs/img/doi/0352-5139/2014/0352-51391400090J.pdf
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Summary:A novel series of N-acetyl-3-aryl-5-(5-(p/o-nitrophenyl)-2-arylfuryl/thienyl) substituted pyrazoline (3a-o) were synthesized by the reaction of 1-aryl-3-(5-(p/o-nitrophenyl)-2-furyl/thienyl)-2-propene-1-one with hydrazine hydrate in acetic acid medium. The structures of the newly synthesized compounds were established by IR, 1H NMR, mass spectra and single crystal X-ray study. The synthesized compounds were subjected to antioxidant activity using DPPH scavenging assay. The compounds 3a, 3f, 3h and 3o showed moderate activity.
ISSN:0352-5139
1820-7421

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