Case Report: CD19 and CD22 CAR-T therapy induced durable complete remission in a patient with refractory plasmablastic lymphoma
IntroductionPlasmablastic lymphoma (PBL) is a rare and highly aggressive form of non-Hodgkin lymphoma that is associated with a poor prognosis. Traditional chemotherapy has demonstrated limited efficacy for PBL. There is currently no standard treatment for patients with refractory or relapsing PBL....
| Published in: | Frontiers in Immunology |
|---|---|
| Main Authors: | Dan Liu, Haichen Wei, Yanran Hu, Hui Wang, Ping Li, Ke Lu, Wenjun Zhang, Lijie Xing, Zengjun Li |
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-10-01
|
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1697566/full |
Similar Items
Bortezomib, Lenalidomide and Dexamethasone Combination Induced Complete Remission in Relapsed/Refractory Plasmablastic Lymphoma: Case Report of a Potential Novel Treatment Approach
by: Waleed Sabry, et al.
Published: (2022-07-01)
by: Waleed Sabry, et al.
Published: (2022-07-01)
Relapsed plasmablastic lymphoma in a HIV‐negative patient: Pushing the envelope
by: Manthan Kathrotiya, et al.
Published: (2021-02-01)
by: Manthan Kathrotiya, et al.
Published: (2021-02-01)
Case Report: BCMA-targeting CAR T-cell therapy induces complete and durable remission in relapsed extramedullary plasmablastic multiple myeloma
by: Lili Zhou, et al.
Published: (2025-05-01)
by: Lili Zhou, et al.
Published: (2025-05-01)
BCMA CAR-T therapy as salvage therapy in patients with plasmablastic myeloma
by: Chengwei Jin, et al.
Published: (2025-12-01)
by: Chengwei Jin, et al.
Published: (2025-12-01)
Two Cases of Plasmablastic Myeloma Mimicking Plasmablastic Lymphoma With In‐Depth Review of Literature
by: Sakiko Kitamura, et al.
Published: (2025-02-01)
by: Sakiko Kitamura, et al.
Published: (2025-02-01)
Plasmablastic lymphoma in an HIV patient with cutaneous presentation: A case of remarkable remission in a typically refractory disease
by: Ijeuru Chikeka, MD, et al.
Published: (2020-03-01)
by: Ijeuru Chikeka, MD, et al.
Published: (2020-03-01)
Plasmablastic Lymphoma
by: Subecha Bhusal, et al.
Published: (2017-07-01)
by: Subecha Bhusal, et al.
Published: (2017-07-01)
Plasmablastic extramedullary plasmacytoma
by: Irulandy Ponniah, et al.
Published: (2012-01-01)
by: Irulandy Ponniah, et al.
Published: (2012-01-01)
The role of daratumumab in relapsed/refractory CD38 positive acute leukemias—case report on three cases with a literature review
by: Witold Prejzner, et al.
Published: (2023-10-01)
by: Witold Prejzner, et al.
Published: (2023-10-01)
The Cytological Diagnosis of Extra-Oral Plasmablastic Lymphoma: A Rare Entity
by: Kanthilatha Pai, et al.
Published: (2013-04-01)
by: Kanthilatha Pai, et al.
Published: (2013-04-01)
High Grade Plasmablastic Lymphoma of the Eyelid in a Young Male
by: Adriana Dávila Camargo, et al.
Published: (2018-03-01)
by: Adriana Dávila Camargo, et al.
Published: (2018-03-01)
Plasmablastic transformation of a double hit follicular lymphoma: An emerging entity
by: Shanaz Khodaiji, et al.
Published: (2024-04-01)
by: Shanaz Khodaiji, et al.
Published: (2024-04-01)
Aberrant CD4 expression in plasmablastic transformation of multiple myeloma
by: Kohei Shiroshita, et al.
Published: (2024-06-01)
by: Kohei Shiroshita, et al.
Published: (2024-06-01)
Daratumumab and venetoclax in combination with chemotherapy provide sustained molecular remission in relapsed/refractory CD19, CD20, and CD22 negative acute B lymphoblastic leukemia with KMT2A-AFF1 transcript
by: Sophie Voruz, et al.
Published: (2021-12-01)
by: Sophie Voruz, et al.
Published: (2021-12-01)
Plasmablastic lymphoma in Malawi
by: Takondwa Zuze, et al.
Published: (2018-06-01)
by: Takondwa Zuze, et al.
Published: (2018-06-01)
Clinicopathologic features and abnormal signaling pathways in plasmablastic lymphoma: a multicenter study in China
by: Di Shi, et al.
Published: (2022-12-01)
by: Di Shi, et al.
Published: (2022-12-01)
Plasmablastic Myeloma- A Diagnostic Dilemma
by: Shiva Kumar Komaravelli, et al.
Published: (2023-05-01)
by: Shiva Kumar Komaravelli, et al.
Published: (2023-05-01)
CD138-Negative Extra-oral Plasmablastic Lymphoma in an Immuno-competent Patient—Diagnostic Challenge: A Case Report and Review of Literature
by: Shweta Katiyar, et al.
by: Shweta Katiyar, et al.
Efficacy and side effects of anti‐CD19 CAR T‐cell therapy in patients with relapsed/refractory gastrointestinal lymphoma
by: Yi Li Jiang, et al.
Published: (2024-02-01)
by: Yi Li Jiang, et al.
Published: (2024-02-01)
Plasmablastic lymphoma with skin involvement in an immunocompetent male
by: Baixue Lv, et al.
Published: (2023-12-01)
by: Baixue Lv, et al.
Published: (2023-12-01)
Plasmablastic lymphoma: current knowledge and future directions
by: Ji-Wei Li, et al.
Published: (2024-02-01)
by: Ji-Wei Li, et al.
Published: (2024-02-01)
A rare case of HIV-negative plasmablastic lymphoma in nasal cavity
by: Yixing Yao, et al.
Published: (2023-11-01)
by: Yixing Yao, et al.
Published: (2023-11-01)
Plasmablastic lymphoma of the sphenoid bone in an immunocompetent patient: A diagnostic challenge
by: Anurag Singh, et al.
Published: (2024-12-01)
by: Anurag Singh, et al.
Published: (2024-12-01)
Treatment of Multiple Myeloma in Patients Refractory to Daratumumab/Anti‐CD38 Monoclonal Antibodies: A Systematic Review
by: Chia Jie Tan, et al.
Published: (2025-03-01)
by: Chia Jie Tan, et al.
Published: (2025-03-01)
Manifestation of plasmablastic lymphoma in the oral cavity: Report of two cases and literature review
by: Letícia da Silva Soares Gomes, et al.
Published: (2024-03-01)
by: Letícia da Silva Soares Gomes, et al.
Published: (2024-03-01)
Oral plasmablastic lymphoma: at the origin of the discovery of an HIV infection
by: Rahman Nurhayu Ab, et al.
Published: (2024-01-01)
by: Rahman Nurhayu Ab, et al.
Published: (2024-01-01)
Primary intracranial plasmablastic lymphoma with intradural extramedullary metastasis: a case report
by: Zhuoru Jiang, et al.
Published: (2025-09-01)
by: Zhuoru Jiang, et al.
Published: (2025-09-01)
Plasmablastic neoplasms with unusual histomorphology: A report of two cases
by: Gamalenkosi Nhlonzi, et al.
Published: (2020-11-01)
by: Gamalenkosi Nhlonzi, et al.
Published: (2020-11-01)
Netrin‐1 and B‐cell maturation antigen expression in a large cohort of 361 lymphomas: sensitive and specific staining in plasmablastic lymphomas, and therapeutic perspectives
by: Marie Donzel, et al.
Published: (2025-05-01)
by: Marie Donzel, et al.
Published: (2025-05-01)
Duodenal plasmablastic lymphoma in an human immunodeficency virus-negative patient: a case report
by: Abbas Ali Hussain, et al.
Published: (2023-10-01)
by: Abbas Ali Hussain, et al.
Published: (2023-10-01)
Intraoral plasmablastic non-hodgkin's lymphoma associated with human immunodeficiency virus
by: Vijeev Vasudevan, et al.
Published: (2016-01-01)
by: Vijeev Vasudevan, et al.
Published: (2016-01-01)
Plasmablastic lymphoma mimicking primary ovarian, tubal or peritoneal cancer: a case report and literature review
by: I-Ning Cheng, et al.
Published: (2025-04-01)
by: I-Ning Cheng, et al.
Published: (2025-04-01)
Plasmablastic lymphoma in epstein–Barr virus-negative patient
by: Ghaidaa R AlSahari, et al.
Published: (2024-01-01)
by: Ghaidaa R AlSahari, et al.
Published: (2024-01-01)
Predictive short/long-term efficacy biomarkers and resistance mechanisms of CD19-directed CAR-T immunotherapy in relapsed/refractory B-cell lymphomas
by: Hao Xu, et al.
Published: (2023-03-01)
by: Hao Xu, et al.
Published: (2023-03-01)
Primary refractory plasmablastic lymphoma: A precision oncology approach
by: Hanno M. Witte, et al.
Published: (2023-02-01)
by: Hanno M. Witte, et al.
Published: (2023-02-01)
Gut-homing conventional plasmablasts and CD27- plasmablasts elicited after a short time exposure to an oral live attenuated Shigella vaccine candidate in humans
by: Franklin R. Toapanta, et al.
Published: (2014-08-01)
by: Franklin R. Toapanta, et al.
Published: (2014-08-01)
Be cautious to adopt a second CAR T-cell infusion after failure of CD19/CD22 cocktail CAR T-cell therapy in relapsed/refractory B-NHL
by: Gaoxiang Wang, et al.
Published: (2025-03-01)
by: Gaoxiang Wang, et al.
Published: (2025-03-01)
Plasmablastic Lymphoma of the Maxillary Sinus Causing Orbital Complication
by: Sedat Aydın, et al.
Published: (2018-09-01)
by: Sedat Aydın, et al.
Published: (2018-09-01)
Long-term survivor of human immunodeficiency virus-associated plasmablastic lymphoma
by: Atul Sharma, et al.
Published: (2013-01-01)
by: Atul Sharma, et al.
Published: (2013-01-01)
Clinical outcomes of pomalidomide‐based and daratumumab‐based therapies in patients with relapsed/refractory multiple myeloma: A real‐world cohort study in China
by: Xiaoyan Han, et al.
Published: (2024-05-01)
by: Xiaoyan Han, et al.
Published: (2024-05-01)
Similar Items
-
Bortezomib, Lenalidomide and Dexamethasone Combination Induced Complete Remission in Relapsed/Refractory Plasmablastic Lymphoma: Case Report of a Potential Novel Treatment Approach
by: Waleed Sabry, et al.
Published: (2022-07-01) -
Relapsed plasmablastic lymphoma in a HIV‐negative patient: Pushing the envelope
by: Manthan Kathrotiya, et al.
Published: (2021-02-01) -
Case Report: BCMA-targeting CAR T-cell therapy induces complete and durable remission in relapsed extramedullary plasmablastic multiple myeloma
by: Lili Zhou, et al.
Published: (2025-05-01) -
BCMA CAR-T therapy as salvage therapy in patients with plasmablastic myeloma
by: Chengwei Jin, et al.
Published: (2025-12-01) -
Two Cases of Plasmablastic Myeloma Mimicking Plasmablastic Lymphoma With In‐Depth Review of Literature
by: Sakiko Kitamura, et al.
Published: (2025-02-01)
