Investigating the effect of Icaritin on hepatocellular carcinoma based on network pharmacology

Hepatocellular carcinoma is one of the cancers that kill people in the global population. Icaritin, a small molecule drug approved by NMPA, has demonstrated potential anti-HCC effects. However, its underlying molecular mechanisms remain unclear. We employed a multi-omics approach in this study, incl...

Full description

Bibliographic Details
Published in:	Frontiers in Pharmacology
Main Authors:	Zhong Xue, Fan Zhang, Shaohua Xu, Minyong Chen, Mingzuo Wang, Ming Wang, Fayong Ke, Zhaoshuo Chen, Mingji Zhang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-05-01
Subjects:	hepatocellular carcinoma Icaritin multi-omics pharmaco-omics proteomics FYN gene
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2023.1208495/full

Similar Items

Hyaluronic acid-modified liposomes Potentiated in-vivo anti-hepatocellular carcinoma of icaritin
by: Xiaoduan Sun, et al.
Published: (2024-07-01)

Icaritin Exerts Anti-Cancer Effects through Modulating Pyroptosis and Immune Activities in Hepatocellular Carcinoma
by: Yuanyuan Jiao, et al.
Published: (2024-08-01)

A comparative study on the in vitro and in vivo antitumor efficacy of icaritin and hydrous icaritin nanorods
by: Haowen Li, et al.
Published: (2020-01-01)

Icaritin Induces Anti-tumor Immune Responses in Hepatocellular Carcinoma by Inhibiting Splenic Myeloid-Derived Suppressor Cell Generation
by: Huimin Tao, et al.
Published: (2021-02-01)

First‐Line Treatment of Icaritin and Thalidomide in a Patient With Hepatocellular Carcinoma With PR: A Case Report
by: Zaiyong Jin, et al.
Published: (2025-03-01)

Corrigendum: Exploring the pharmacological mechanisms of icaritin against nasopharyngeal carcinoma via network pharmacology and experimental validation
by: Minglu Liu, et al.
Published: (2023-01-01)

Involvement of icaritin in the regulation of osteocyte exosomal microRNAs
by: Kaijia Zhang, et al.
Published: (2025-02-01)

Mechanism of action of icaritin on uterine corpus endometrial carcinoma based on network pharmacology and experimental evaluation
by: Yan-Bin Jin, et al.
Published: (2023-07-01)

Comprehensive molecular characteristics of hepatocellular carcinoma based on multi-omics analysis
by: Ying-Ying Wang, et al.
Published: (2025-03-01)

Antiosteoporosis Effects, Pharmacokinetics, and Drug Delivery Systems of Icaritin: Advances and Prospects
by: Lifang Gao, et al.
Published: (2022-03-01)

Therapeutic Effect of Icaritin on Cerebral Ischemia-Reperfusion-Induced Senescence and Apoptosis in an Acute Ischemic Stroke Mouse Model
by: Cheng-Tien Wu, et al.
Published: (2022-09-01)

Icaritin Derivative IC2 Induces Cytoprotective Autophagy of Breast Cancer Cells via SCD1 Inhibition
by: Yi-Xuan Wang, et al.
Published: (2023-01-01)

Mass spectrometry-based multi-omics analysis reveals distinct molecular features in early and advanced stages of hepatocellular carcinoma
by: Mingzhu Fan, et al.
Published: (2024-10-01)

Preparation, Characterization, and In Vivo Evaluation of Amorphous Icaritin Nanoparticles Prepared by a Reactive Precipitation Technique
by: Cheng Tang, et al.
Published: (2021-05-01)

Discovery and validation of CREB1 as a transcription target of icaritin: Implications for the treatment of depressive-like behavior
by: Ling Gu, et al.
Published: (2025-03-01)

Effect of icaritin on autophagy-related protein expression in TDP-43-transfected SH-SY5Y cells
by: Yanjun Zhou, et al.
Published: (2022-07-01)

Enhanced Oral Absorption of Icaritin by Using Mixed Polymeric Micelles Prepared with a Creative Acid-Base Shift Method
by: Cheng Tang, et al.
Published: (2021-06-01)

Highly efficient bioconversion of icariin to icaritin by whole-cell catalysis
by: Yu Lin, et al.
Published: (2023-04-01)

Advances in multi-omics studies of microvascular invasion in hepatocellular carcinoma
by: Lili Wang, et al.
Published: (2025-03-01)

Icaritin and lenvatinib treatment for unresectable localized progressive pancreatic cancer: a report of six cases
by: Xiaolong Liu, et al.
Published: (2025-12-01)

Anticancer effect of icaritin on prostate cancer via regulating miR‐381‐3p and its target gene UBE2C
by: Jimeng Hu, et al.
Published: (2019-12-01)

Proteomic and metabolomic analysis of platelet related samples reveals energy metabolism disorders in hepatocellular carcinoma
by: Xuelian Ruan, et al.
Published: (2025-06-01)

Integrating Molecular Perspectives: Strategies for Comprehensive Multi-Omics Integrative Data Analysis and Machine Learning Applications in Transcriptomics, Proteomics, and Metabolomics
by: Pedro H. Godoy Sanches, et al.
Published: (2024-10-01)

Lipid droplet formation induced by icaritin derivative IC2 promotes a combination strategy for cancer therapy
by: Guosheng Wu, et al.
Published: (2024-12-01)

Icaritin Promotes Myelination by Simultaneously Enhancing the Proliferation and Differentiation of Oligodendrocyte Precursor Cells
by: Feifei Yang, et al.
Published: (2023-08-01)

Icaritin inhibits the progression of urothelial cancer by suppressing PADI2-mediated neutrophil infiltration and neutrophil extracellular trap formation
by: Zezhong Mou, et al.
Published: (2024-09-01)

Icaritin Represses Autophagy to Promote Colorectal Cancer Cell Apoptosis and Sensitized Low‐Temperature Photothermal Therapy via Targeting HSP90‐TXNDC9 Interactions
by: Dan He, et al.
Published: (2025-05-01)

Parallel Multi-Omics in High-Risk Subjects for the Identification of Integrated Biomarker Signatures of Type 1 Diabetes
by: Oscar Alcazar, et al.
Published: (2021-03-01)

Multi-omic analysis identifies the molecular mechanism of hepatocellular carcinoma with cirrhosis
by: Mengjuan Xuan, et al.
Published: (2024-10-01)

Prognostic value of SH3PXD2B (Tks4) in human hepatocellular carcinoma: a combined multi-omics and experimental study
by: Xiang Kui, et al.
Published: (2021-04-01)

Multi-omics analysis of lactate metabolism gene regulation in Clonorchis sinensis-associated hepatocellular carcinoma
by: Qiumei Lin, et al.
Published: (2025-07-01)

Urinary biomarkers for hepatocellular carcinoma: current knowledge for clinicians
by: Kaige Deng, et al.
Published: (2023-10-01)

UHPLC-ESI-QE-Orbitrap-MS based metabolomics reveals the antioxidant mechanism of icaritin on mice with cerebral ischemic reperfusion
by: Yunfeng Tang, et al.
Published: (2023-01-01)

Integrated Multiomics Reveals Silencing of has_circ_0006646 Promotes TRIM21‐Mediated NCL Ubiquitination to Inhibit Hepatocellular Carcinoma Metastasis
by: Xin Hu, et al.
Published: (2024-04-01)

Microenvironment characterization and multi-omics signatures related to prognosis and immunotherapy response of hepatocellular carcinoma
by: Furong Liu, et al.
Published: (2020-05-01)

Omics in Radiation Biology: Surprised but Not Disappointed
by: Prabal Subedi, et al.
Published: (2022-02-01)

Multi-omics analysis of pyroptosis regulation patterns and characterization of tumor microenvironment in patients with hepatocellular carcinoma
by: Bingbing Shang, et al.
Published: (2023-05-01)

Bioactive Flavonoids Icaritin and Icariin Protect against Cerebral Ischemia–Reperfusion-Associated Apoptosis and Extracellular Matrix Accumulation in an Ischemic Stroke Mouse Model
by: Cheng-Tien Wu, et al.
Published: (2021-11-01)

A Single-Cell Atlas of the Substantia Nigra Reveals Therapeutic Effects of Icaritin in a Rat Model of Parkinson’s Disease
by: Hao Wu, et al.
Published: (2024-09-01)

Integrating single-cell and bulk RNA sequencing data to characterize the heterogeneity of glycan-lipid metabolism polarization in hepatocellular carcinoma
by: Peng Lin, et al.
Published: (2025-03-01)