Translational Research in FLASH Radiotherapy—From Radiobiological Mechanisms to In Vivo Results
FLASH radiotherapy, or the administration of ultra-high dose rate radiotherapy, is a new radiation delivery method that aims to widen the therapeutic window in radiotherapy. Thus far, most in vitro and in vivo results show a real potential of FLASH to offer superior normal tissue sparing compared to...
| الحاوية / القاعدة: | Biomedicines |
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| المؤلفون الرئيسيون: | , , , |
| التنسيق: | مقال |
| اللغة: | الإنجليزية |
| منشور في: |
MDPI AG
2021-02-01
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| الموضوعات: | |
| الوصول للمادة أونلاين: | https://www.mdpi.com/2227-9059/9/2/181 |
| _version_ | 1850271349222670336 |
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| author | Loredana G. Marcu Eva Bezak Dylan D. Peukert Puthenparampil Wilson |
| author_facet | Loredana G. Marcu Eva Bezak Dylan D. Peukert Puthenparampil Wilson |
| author_sort | Loredana G. Marcu |
| collection | DOAJ |
| container_title | Biomedicines |
| description | FLASH radiotherapy, or the administration of ultra-high dose rate radiotherapy, is a new radiation delivery method that aims to widen the therapeutic window in radiotherapy. Thus far, most in vitro and in vivo results show a real potential of FLASH to offer superior normal tissue sparing compared to conventionally delivered radiation. While there are several postulations behind the differential behaviour among normal and cancer cells under FLASH, the full spectra of radiobiological mechanisms are yet to be clarified. Currently the number of devices delivering FLASH dose rate is few and is mainly limited to experimental and modified linear accelerators. Nevertheless, FLASH research is increasing with new developments in all the main areas: radiobiology, technology and clinical research. This paper presents the current status of FLASH radiotherapy with the aforementioned aspects in mind, but also to highlight the existing challenges and future prospects to overcome them. |
| format | Article |
| id | doaj-art-2827e91d59cd42b8b133ead032e84613 |
| institution | Directory of Open Access Journals |
| issn | 2227-9059 |
| language | English |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| spelling | doaj-art-2827e91d59cd42b8b133ead032e846132025-08-19T23:42:41ZengMDPI AGBiomedicines2227-90592021-02-019218110.3390/biomedicines9020181Translational Research in FLASH Radiotherapy—From Radiobiological Mechanisms to In Vivo ResultsLoredana G. Marcu0Eva Bezak1Dylan D. Peukert2Puthenparampil Wilson3Faculty of Informatics & Science, Department of Physics, University of Oradea, 410087 Oradea, RomaniaCancer Research Institute and School of Health Sciences, University of South Australia, Adelaide, SA 5001, AustraliaSchool of Civil, Environmental & Mining Engineering, University of Adelaide, North Terrace, Adelaide, SA 5005, AustraliaSTEM, University of South Australia, Adelaide, SA 5001, AustraliaFLASH radiotherapy, or the administration of ultra-high dose rate radiotherapy, is a new radiation delivery method that aims to widen the therapeutic window in radiotherapy. Thus far, most in vitro and in vivo results show a real potential of FLASH to offer superior normal tissue sparing compared to conventionally delivered radiation. While there are several postulations behind the differential behaviour among normal and cancer cells under FLASH, the full spectra of radiobiological mechanisms are yet to be clarified. Currently the number of devices delivering FLASH dose rate is few and is mainly limited to experimental and modified linear accelerators. Nevertheless, FLASH research is increasing with new developments in all the main areas: radiobiology, technology and clinical research. This paper presents the current status of FLASH radiotherapy with the aforementioned aspects in mind, but also to highlight the existing challenges and future prospects to overcome them.https://www.mdpi.com/2227-9059/9/2/181ultra-high dose ratenormal tissue sparingFLASH-radiotherapyFLASH-radiobiologytherapeutic window |
| spellingShingle | Loredana G. Marcu Eva Bezak Dylan D. Peukert Puthenparampil Wilson Translational Research in FLASH Radiotherapy—From Radiobiological Mechanisms to In Vivo Results ultra-high dose rate normal tissue sparing FLASH-radiotherapy FLASH-radiobiology therapeutic window |
| title | Translational Research in FLASH Radiotherapy—From Radiobiological Mechanisms to In Vivo Results |
| title_full | Translational Research in FLASH Radiotherapy—From Radiobiological Mechanisms to In Vivo Results |
| title_fullStr | Translational Research in FLASH Radiotherapy—From Radiobiological Mechanisms to In Vivo Results |
| title_full_unstemmed | Translational Research in FLASH Radiotherapy—From Radiobiological Mechanisms to In Vivo Results |
| title_short | Translational Research in FLASH Radiotherapy—From Radiobiological Mechanisms to In Vivo Results |
| title_sort | translational research in flash radiotherapy from radiobiological mechanisms to in vivo results |
| topic | ultra-high dose rate normal tissue sparing FLASH-radiotherapy FLASH-radiobiology therapeutic window |
| url | https://www.mdpi.com/2227-9059/9/2/181 |
| work_keys_str_mv | AT loredanagmarcu translationalresearchinflashradiotherapyfromradiobiologicalmechanismstoinvivoresults AT evabezak translationalresearchinflashradiotherapyfromradiobiologicalmechanismstoinvivoresults AT dylandpeukert translationalresearchinflashradiotherapyfromradiobiologicalmechanismstoinvivoresults AT puthenparampilwilson translationalresearchinflashradiotherapyfromradiobiologicalmechanismstoinvivoresults |