Examination of the causal role of immune cells in non-alcoholic fatty liver disease by a bidirectional Mendelian randomization study

Non-alcoholic fatty liver disease (NAFLD) is a globally widespread disease. Recent investigations have highlighted a close association between immunity and NAFLD, but the causality between them has not been thoroughly examined.

書目詳細資料
發表在:Open Medicine
Main Authors: Li Yu, Lv Xiaodan, Lin Jianing, Li Shiquan, Lin Guangfu, Huang Zhixi, Chen Deyi, Han Lichun, Zhan Lingling, Lv Xiaoping
格式: Article
語言:英语
出版: De Gruyter 2025-02-01
主題:
在線閱讀:https://doi.org/10.1515/med-2025-1154
_version_ 1849485097227517952
author Li Yu
Lv Xiaodan
Lin Jianing
Li Shiquan
Lin Guangfu
Huang Zhixi
Chen Deyi
Han Lichun
Zhan Lingling
Lv Xiaoping
author_facet Li Yu
Lv Xiaodan
Lin Jianing
Li Shiquan
Lin Guangfu
Huang Zhixi
Chen Deyi
Han Lichun
Zhan Lingling
Lv Xiaoping
author_sort Li Yu
collection DOAJ
container_title Open Medicine
description Non-alcoholic fatty liver disease (NAFLD) is a globally widespread disease. Recent investigations have highlighted a close association between immunity and NAFLD, but the causality between them has not been thoroughly examined.
format Article
id doaj-art-283ddb981b624db0b4e4abca636dfd5a
institution Directory of Open Access Journals
issn 2391-5463
language English
publishDate 2025-02-01
publisher De Gruyter
record_format Article
spelling doaj-art-283ddb981b624db0b4e4abca636dfd5a2025-08-20T03:10:49ZengDe GruyterOpen Medicine2391-54632025-02-012014195710.1515/med-2025-1154Examination of the causal role of immune cells in non-alcoholic fatty liver disease by a bidirectional Mendelian randomization studyLi Yu0Lv Xiaodan1Lin Jianing2Li Shiquan3Lin Guangfu4Huang Zhixi5Chen Deyi6Han Lichun7Zhan Lingling8Lv Xiaoping9Department of Gastroenterology, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi, ChinaDepartment of Clinical Experimental Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, ChinaDepartment of Gastroenterology, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi, ChinaDepartment of Gastroenterology, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi, ChinaDepartment of Gastroenterology, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi, ChinaDepartment of Gastroenterology, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi, ChinaDepartment of Gastroenterology, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi, ChinaDepartment of Gastroenterology, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi, ChinaDepartment of Clinical Experimental Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, ChinaDepartment of Gastroenterology, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi, ChinaNon-alcoholic fatty liver disease (NAFLD) is a globally widespread disease. Recent investigations have highlighted a close association between immunity and NAFLD, but the causality between them has not been thoroughly examined.https://doi.org/10.1515/med-2025-1154mendelian randomizationnon-alcoholic fatty liver diseaseimmune cellcausal inference
spellingShingle Li Yu
Lv Xiaodan
Lin Jianing
Li Shiquan
Lin Guangfu
Huang Zhixi
Chen Deyi
Han Lichun
Zhan Lingling
Lv Xiaoping
Examination of the causal role of immune cells in non-alcoholic fatty liver disease by a bidirectional Mendelian randomization study
mendelian randomization
non-alcoholic fatty liver disease
immune cell
causal inference
title Examination of the causal role of immune cells in non-alcoholic fatty liver disease by a bidirectional Mendelian randomization study
title_full Examination of the causal role of immune cells in non-alcoholic fatty liver disease by a bidirectional Mendelian randomization study
title_fullStr Examination of the causal role of immune cells in non-alcoholic fatty liver disease by a bidirectional Mendelian randomization study
title_full_unstemmed Examination of the causal role of immune cells in non-alcoholic fatty liver disease by a bidirectional Mendelian randomization study
title_short Examination of the causal role of immune cells in non-alcoholic fatty liver disease by a bidirectional Mendelian randomization study
title_sort examination of the causal role of immune cells in non alcoholic fatty liver disease by a bidirectional mendelian randomization study
topic mendelian randomization
non-alcoholic fatty liver disease
immune cell
causal inference
url https://doi.org/10.1515/med-2025-1154
work_keys_str_mv AT liyu examinationofthecausalroleofimmunecellsinnonalcoholicfattyliverdiseasebyabidirectionalmendelianrandomizationstudy
AT lvxiaodan examinationofthecausalroleofimmunecellsinnonalcoholicfattyliverdiseasebyabidirectionalmendelianrandomizationstudy
AT linjianing examinationofthecausalroleofimmunecellsinnonalcoholicfattyliverdiseasebyabidirectionalmendelianrandomizationstudy
AT lishiquan examinationofthecausalroleofimmunecellsinnonalcoholicfattyliverdiseasebyabidirectionalmendelianrandomizationstudy
AT linguangfu examinationofthecausalroleofimmunecellsinnonalcoholicfattyliverdiseasebyabidirectionalmendelianrandomizationstudy
AT huangzhixi examinationofthecausalroleofimmunecellsinnonalcoholicfattyliverdiseasebyabidirectionalmendelianrandomizationstudy
AT chendeyi examinationofthecausalroleofimmunecellsinnonalcoholicfattyliverdiseasebyabidirectionalmendelianrandomizationstudy
AT hanlichun examinationofthecausalroleofimmunecellsinnonalcoholicfattyliverdiseasebyabidirectionalmendelianrandomizationstudy
AT zhanlingling examinationofthecausalroleofimmunecellsinnonalcoholicfattyliverdiseasebyabidirectionalmendelianrandomizationstudy
AT lvxiaoping examinationofthecausalroleofimmunecellsinnonalcoholicfattyliverdiseasebyabidirectionalmendelianrandomizationstudy