Canonical and noncanonical autophagy: involvement in Parkinson’s disease
Autophagy is the major degradation process in cells and is involved in a variety of physiological and pathological functions. While macroautophagy, which employs a series of molecular cascades to form ATG8-coated double membrane autophagosomes for degradation, remains the well-known type of canonica...
| Published in: | Frontiers in Cell and Developmental Biology |
|---|---|
| Main Authors: | Maria Sakurai, Tomoki Kuwahara |
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-01-01
|
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2025.1518991/full |
Similar Items
Canonical and Noncanonical Autophagy as Potential Targets for COVID-19
by: Melissa Bello-Perez, et al.
Published: (2020-07-01)
by: Melissa Bello-Perez, et al.
Published: (2020-07-01)
Novel autophagy inducers by accelerating lysosomal clustering against Parkinson’s disease
by: Yuki Date, et al.
Published: (2024-06-01)
by: Yuki Date, et al.
Published: (2024-06-01)
The Consequences of GBA Deficiency in the Autophagy–Lysosome System in Parkinson’s Disease Associated with GBA
by: Eddie Pradas, et al.
Published: (2023-01-01)
by: Eddie Pradas, et al.
Published: (2023-01-01)
Getting PIKy with the lysosome membrane (again)
by: Alison D. Klein, et al.
Published: (2024-12-01)
by: Alison D. Klein, et al.
Published: (2024-12-01)
Noncanonical autophagy in systemic lupus erythematosus
by: Ting Gan, et al.
Published: (2021-12-01)
by: Ting Gan, et al.
Published: (2021-12-01)
Autophagy in Parkinson’s Disease
by: Lior Nechushtai, et al.
Published: (2023-09-01)
by: Lior Nechushtai, et al.
Published: (2023-09-01)
Lysosome-associated CASM: from upstream triggers to downstream effector mechanisms
by: Namrita Kaur, et al.
Published: (2025-03-01)
by: Namrita Kaur, et al.
Published: (2025-03-01)
Unraveling the mystery: How autophagy deficiency in dopaminergic neurons drives human Parkinson’s disease
by: Sachiko Noda, et al.
Published: (2025-07-01)
by: Sachiko Noda, et al.
Published: (2025-07-01)
Autophagic- and Lysosomal-Related Biomarkers for Parkinson’s Disease: Lights and Shadows
by: Helena Xicoy, et al.
Published: (2019-10-01)
by: Helena Xicoy, et al.
Published: (2019-10-01)
Dynamics of a model for the degradation mechanism of aggregated α-synuclein in Parkinson's disease
by: Bojie Yang, et al.
Published: (2023-04-01)
by: Bojie Yang, et al.
Published: (2023-04-01)
Cross-talk between traditional Chinese medicine and Parkinson's disease based on cell autophagy
by: Mufei Wang, et al.
Published: (2023-06-01)
by: Mufei Wang, et al.
Published: (2023-06-01)
Autophagy and LRRK2 in the Aging Brain
by: Federica Albanese, et al.
Published: (2019-12-01)
by: Federica Albanese, et al.
Published: (2019-12-01)
The autophagy–lysosome pathway: a potential target in the chemical and gene therapeutic strategies for Parkinson’s disease
by: Fengjuan Jiao, et al.
Published: (2025-01-01)
by: Fengjuan Jiao, et al.
Published: (2025-01-01)
LRRK2 inhibitors and their potential in the treatment of Parkinson’s disease: current perspectives
by: Atashrazm F, et al.
Published: (2016-10-01)
by: Atashrazm F, et al.
Published: (2016-10-01)
The role of autophagy in synucleinopathy: clearance versus spread of α-synuclein
by: Emily Birnbaum, et al.
Published: (2025-12-01)
by: Emily Birnbaum, et al.
Published: (2025-12-01)
Autophagy, Acute Pancreatitis and the Metamorphoses of a Trypsinogen-Activating Organelle
by: Svetlana Voronina, et al.
Published: (2022-08-01)
by: Svetlana Voronina, et al.
Published: (2022-08-01)
Autophagy and Bacterial infections
by: Ken Cadwell, et al.
Published: (2025-12-01)
by: Ken Cadwell, et al.
Published: (2025-12-01)
Pathogenic Aspects and Therapeutic Avenues of Autophagy in Parkinson’s Disease
by: Rémi Kinet, et al.
Published: (2023-02-01)
by: Rémi Kinet, et al.
Published: (2023-02-01)
Autophagy-Lysosomal Pathway as Potential Therapeutic Target in Parkinson’s Disease
by: Srinivasa Reddy Bonam, et al.
Published: (2021-12-01)
by: Srinivasa Reddy Bonam, et al.
Published: (2021-12-01)
Chronic Caffeine Treatment Protects Against α-Synucleinopathy by Reestablishing Autophagy Activity in the Mouse Striatum
by: Yanan Luan, et al.
Published: (2018-05-01)
by: Yanan Luan, et al.
Published: (2018-05-01)
“Janus-Faced” α-Synuclein: Role in Parkinson’s Disease
by: Bipul Ray, et al.
Published: (2021-05-01)
by: Bipul Ray, et al.
Published: (2021-05-01)
LRRK2 and α-Synuclein: Distinct or Synergistic Players in Parkinson’s Disease?
by: Darren M. O’Hara, et al.
Published: (2020-06-01)
by: Darren M. O’Hara, et al.
Published: (2020-06-01)
Exercise-Induced Autophagy Ameliorates Motor Symptoms Progressivity in Parkinson’s Disease Through Alpha-Synuclein Degradation: A Review
by: Goenawan H, et al.
Published: (2023-05-01)
by: Goenawan H, et al.
Published: (2023-05-01)
Dynactin knockdown leads to synuclein aggregation by blocking autophagy in a zebrafish model of Parkinson's disease
by: Yongmei Wu, et al.
Published: (2025-03-01)
by: Yongmei Wu, et al.
Published: (2025-03-01)
Roles of neuronal lysosomes in the etiology of Parkinson's disease
by: Mattia Volta
Published: (2024-01-01)
by: Mattia Volta
Published: (2024-01-01)
Autophagy Modulation as a Treatment of Amyloid Diseases
by: Zoe Mputhia, et al.
Published: (2019-09-01)
by: Zoe Mputhia, et al.
Published: (2019-09-01)
Crosstalk between presynaptic trafficking and autophagy in Parkinson's disease
by: Ping-Yue Pan, et al.
Published: (2019-02-01)
by: Ping-Yue Pan, et al.
Published: (2019-02-01)
Synergistic Effect of Mitochondrial and Lysosomal Dysfunction in Parkinson’s Disease
by: Flora Guerra, et al.
Published: (2019-05-01)
by: Flora Guerra, et al.
Published: (2019-05-01)
The Emerging Role of the Lysosome in Parkinson’s Disease
by: Alba Navarro-Romero, et al.
Published: (2020-11-01)
by: Alba Navarro-Romero, et al.
Published: (2020-11-01)
Nurr1 deficiency impairs autophagy-lysosomal function through GBA-dependent transcriptional regulation in Parkinson’s disease pathogenesis
by: Cheng Cheng, et al.
Published: (2025-06-01)
by: Cheng Cheng, et al.
Published: (2025-06-01)
TFE3-mediated neuroprotection: Clearance of aggregated α-synuclein and accumulated mitochondria in the AAV-α-synuclein model of Parkinson's disease
by: Xin He, et al.
Published: (2025-03-01)
by: Xin He, et al.
Published: (2025-03-01)
Corynoxine B targets at HMGB1/2 to enhance autophagy for α-synuclein clearance in fly and rodent models of Parkinson's disease
by: Qi Zhu, et al.
Published: (2023-06-01)
by: Qi Zhu, et al.
Published: (2023-06-01)
Lactulose and Melibiose Inhibit α-Synuclein Aggregation and Up-Regulate Autophagy to Reduce Neuronal Vulnerability
by: Chiung Mei Chen, et al.
Published: (2020-05-01)
by: Chiung Mei Chen, et al.
Published: (2020-05-01)
α-Synuclein disrupts microglial autophagy through STAT1-dependent suppression of Ulk1 transcription
by: Chong-Shuang Pei, et al.
Published: (2024-10-01)
by: Chong-Shuang Pei, et al.
Published: (2024-10-01)
Pharmaceutical Agents for Targeting Autophagy and Their Applications in Clinics
by: Ulash Kench, et al.
Published: (2024-10-01)
by: Ulash Kench, et al.
Published: (2024-10-01)
Exposure of α-Synuclein Aggregates to Organotypic Slice Cultures Recapitulates Key Molecular Features of Parkinson's Disease
by: Serge Moudio, et al.
Published: (2022-02-01)
by: Serge Moudio, et al.
Published: (2022-02-01)
Alpha-Synuclein and LRRK2 in Synaptic Autophagy: Linking Early Dysfunction to Late-Stage Pathology in Parkinson’s Disease
by: Giulia Lamonaca, et al.
Published: (2020-04-01)
by: Giulia Lamonaca, et al.
Published: (2020-04-01)
Crosstalk of organelles in Parkinson’s disease – MiT family transcription factors as central players in signaling pathways connecting mitochondria and lysosomes
by: Martin Lang, et al.
Published: (2022-07-01)
by: Martin Lang, et al.
Published: (2022-07-01)
The emerging roles of autophagy in the homeostasis of lysosome-related organelles
by: Xinran Wang, et al.
Published: (2025-09-01)
by: Xinran Wang, et al.
Published: (2025-09-01)
Dihydromyricetin and Salvianolic acid B inhibit alpha-synuclein aggregation and enhance chaperone-mediated autophagy
by: Jia-Zhen Wu, et al.
Published: (2019-06-01)
by: Jia-Zhen Wu, et al.
Published: (2019-06-01)
Similar Items
-
Canonical and Noncanonical Autophagy as Potential Targets for COVID-19
by: Melissa Bello-Perez, et al.
Published: (2020-07-01) -
Novel autophagy inducers by accelerating lysosomal clustering against Parkinson’s disease
by: Yuki Date, et al.
Published: (2024-06-01) -
The Consequences of GBA Deficiency in the Autophagy–Lysosome System in Parkinson’s Disease Associated with GBA
by: Eddie Pradas, et al.
Published: (2023-01-01) -
Getting PIKy with the lysosome membrane (again)
by: Alison D. Klein, et al.
Published: (2024-12-01) -
Noncanonical autophagy in systemic lupus erythematosus
by: Ting Gan, et al.
Published: (2021-12-01)
