The effect of early oral postoperative feeding on the recovery of intestinal motility after gastrointestinal surgery: a systematic review and meta-analysis of randomized clinical trials

• Published in: Frontiers in Nutrition
• Main Authors: Federica Canzan, Jessica Longhini, Arianna Caliaro, Maria Luisa Cavada, Elisabetta Mezzalira, Salvatore Paiella, Elisa Ambrosi
• Format: Article
• Language: English
• Published: Frontiers Media S.A. 2024-05-01
• Subjects: early feeding; oral feeding; gastrointestinal surgery; ileus; length of hospital stay
• Online Access: https://www.frontiersin.org/articles/10.3389/fnut.2024.1369141/full

Background and aimsPostoperative ileus is a frequent condition, leading to complications and a longer hospital stay. Few studies have demonstrated the benefit of early oral feeding in preventing ileus after gastrointestinal surgery. This study aims to evaluate the efficacy of early versus delayed oral feeding on the recovery of intestinal motility, length of hospital stay, and complications.MethodsWe conducted a systematic review and meta-analysis of randomized control trials, searching PubMed, Embase, Cumulative Index to Nursing and Allied Health Literature, Cochrane Central Register of Controlled Trials, and the ClincalTrials.gov until 31 December 2022. We evaluated the first passage of the stool, the first flatus, complications, length of postoperative stay, and vomiting. We assessed the risk of bias using the Cochrane risk of bias tool (version 2) for randomized trials and the quality of evidence using the Grading of Recommendations Assessment, Development, and Evaluation methodology.ResultsWe included 34 studies with a median sample size of 102 participants. With a moderate certainty of the evidence, the early oral feeding may reduce the time taken for the first passage of the stool (MD −0.99 days; CI 95% −1.25, −0.72), the first flatus (MD −0.70 days; CI 95% -0.87, −0.53), and the risk of complications (RR 0.69; CI 95% 0.59–0.80), while with a low certainty of evidence, it may reduce the length of stay (MD −1.31 days; CI 95% −1.59, −1.03). However, early feeding likely does not affect the risk of vomiting (RR 0.90; CI 95% 0.68, 1.18).ConclusionThis review suggests that early oral feeding after gastrointestinal surgery may lead to a faster intestinal recovery, shorter postoperative stays, and fewer complications. However, careful interpretation is needed due to high heterogeneity and the moderate-to-low quality of evidence. Future studies should focus on the type and starting time of early oral feeding.